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公开(公告)号:US20200046745A1
公开(公告)日:2020-02-13
申请号:US16595633
申请日:2019-10-08
发明人: Stephen J. Baker , Virginia Sanders , Tsutomo Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号:US09796735B2
公开(公告)日:2017-10-24
申请号:US14536483
申请日:2014-11-07
发明人: Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC分类号: C07F5/025 , A61K31/69 , Y02A50/387
摘要: The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
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公开(公告)号:US20170258819A1
公开(公告)日:2017-09-14
申请号:US15599203
申请日:2017-05-18
发明人: Stephen J. BAKER , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
CPC分类号: A61K31/69 , C07F5/027 , Y02A50/411
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号:US20170066788A1
公开(公告)日:2017-03-09
申请号:US15355813
申请日:2016-11-18
发明人: Stephen J. BAKER , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号: C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20160228463A1
公开(公告)日:2016-08-11
申请号:US15134286
申请日:2016-04-20
发明人: Stephen J. BAKER , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson , James J. Leyden
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US09353133B2
公开(公告)日:2016-05-31
申请号:US14201459
申请日:2014-03-07
发明人: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04 , C07F5/02 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , A61K31/69 , A61K31/70 , A61K31/7076
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US08889656B2
公开(公告)日:2014-11-18
申请号:US13874329
申请日:2013-04-30
发明人: Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号: C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US08546357B2
公开(公告)日:2013-10-01
申请号:US13678578
申请日:2012-11-16
发明人: Tsutomu Akama , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
IPC分类号: A61K31/69 , A61K31/42 , C07D231/00 , C07D207/40 , C07F5/04
摘要: This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
摘要翻译: 本发明提供新化合物,使用该化合物的方法和含有这些化合物的药物组合物。
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公开(公告)号:US20230008130A1
公开(公告)日:2023-01-12
申请号:US17869351
申请日:2022-07-20
发明人: Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号:US20200179418A1
公开(公告)日:2020-06-11
申请号:US16789777
申请日:2020-02-13
发明人: Stephen J. Baker , Virginia Sanders , Tsutomo Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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