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公开(公告)号：US10774096B2
公开(公告)日：2020-09-15
申请号：US15550693
申请日：2016-02-12
发明人： Carlos Alemparte-Gallardo , Michael Richard Kevin (Dickon) Alley , David Barros-Aguirre , Ilaria Giordano , Vincent Hernandez , Xianfeng Li , Jacob J. Plattner
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CH2CH3, —CH2═CH2, —CH2CH2CH3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20200247828A1
公开(公告)日：2020-08-06
申请号：US16856332
申请日：2020-04-23
发明人： Tsutomu Akama , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US10669291B2
公开(公告)日：2020-06-02
申请号：US16241841
申请日：2019-01-07
发明人： Tsutomu Akama , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US20200046745A1
公开(公告)日：2020-02-13
申请号：US16595633
申请日：2019-10-08
发明人： Stephen J. Baker , Virginia Sanders , Tsutomo Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：US10526352B2
公开(公告)日：2020-01-07
申请号：US16385547
申请日：2019-04-16
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20190241586A1
公开(公告)日：2019-08-08
申请号：US16385547
申请日：2019-04-16
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US09796735B2
公开(公告)日：2017-10-24
申请号：US14536483
申请日：2014-11-07
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/387
摘要： The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
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公开(公告)号：US20170258819A1
公开(公告)日：2017-09-14
申请号：US15599203
申请日：2017-05-18
发明人： Stephen J. BAKER , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
CPC分类号： A61K31/69 , C07F5/027 , Y02A50/411
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：US20170066788A1
公开(公告)日：2017-03-09
申请号：US15355813
申请日：2016-11-18
发明人： Stephen J. BAKER , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20160340369A1
公开(公告)日：2016-11-24
申请号：US15227112
申请日：2016-08-03
发明人： Daitao CHEN , Matthew Orr , Jessica Sligar , Robert Jacobs , Jacob J. Plattner
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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