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公开(公告)号：US20240428375A1
公开(公告)日：2024-12-26
申请号：US18826296
申请日：2024-09-06
Applicant: CELLOPTIC, INC.
Inventor： Nisan SIEGEL , Gary Brooker
IPC: G06T3/4076 , G03H1/26 , G06T5/50 , G06T7/00
Abstract: An advance in ultra-high-resolution optical imaging has been achieved by the introduction of iterative high-resolution image-building algorithms to incoherent holography. A recorded FINCH hologram is used as the basis of a method in which a high resolution image is built using detailed knowledge of the point spread functions of the FINCH hologram or reconstructed image, and then iteratively improved by successive algorithm generations of comparison to the recorded FINCH hologram and alteration of the high resolution image.
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公开(公告)号：US12078963B2
公开(公告)日：2024-09-03
申请号：US17322326
申请日：2021-05-17
Applicant: CELLOPTIC, INC.
Inventor： Gary Brooker , Nisan Siegel
CPC classification number: G03H1/0005 , G02B21/361 , G02B21/367 , G02B27/58 , G03H1/041 , G03H1/0443 , G03H1/0486 , G03H1/06 , G03H1/28 , G03H2001/005 , G03H2001/0447 , G03H2001/0452 , G03H2001/0458 , G03H1/0493 , G03H2210/33 , G03H2222/31 , G03H2222/34 , G03H2222/36 , G03H2223/12 , G03H2223/17 , G03H2223/52 , G03H2240/56
Abstract: A system and method to produce a hologram of a single plane of a three dimensional object includes an electromagnetic radiation assembly to elicit electromagnetic radiation from a single plane of said object, and an assembly to direct the elicited electromagnetic radiation toward a hologram-forming assembly. The hologram-forming assembly creates a hologram that is recorded by an image capture assembly and then further processed to create maximum resolution images free of an inherent holographic artifact.
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公开(公告)号：US10859977B2
公开(公告)日：2020-12-08
申请号：US16459888
申请日：2019-07-02
Applicant: CELLOPTIC, INC.
Inventor： Joseph Rosen , Gary Brooker
Abstract: An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.
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4.发明申请公开(公告)号：US20150212488A1
公开(公告)日：2015-07-30
申请号：US14680777
申请日：2015-04-07
Applicant: CellOptic, Inc.
Inventor： Joseph ROSEN , Gary BROOKER
Abstract: An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.
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公开(公告)号：US20110267665A1
公开(公告)日：2011-11-03
申请号：US13184279
申请日：2011-07-15
Applicant: Joseph ROSEN
Inventor： Joseph ROSEN
CPC classification number: G03H1/0866 , G02B5/1876 , G03H1/041 , G03H1/0443 , G03H1/06 , G03H1/08 , G03H1/0891 , G03H5/00 , G03H2001/0224 , G03H2001/0447 , G03H2001/0452 , G03H2001/0458 , G03H2210/30 , G03H2223/23
Abstract: An apparatus for producing a hologram of an object includes a light source that emits an incoherent electromagnetic wave toward the object, and a masking device configured to display a mask, receive the incoherent electromagnetic wave emitted toward the object, mask the received incoherent electromagnetic wave according to the displayed mask, and produce a masked electromagnetic wave. The apparatus also includes an image recording device configured to capture an image of the masked electromagnetic wave, and a processing device configured to convert the image of the masked electromagnetic wave into the hologram of the object. A method for producing a hologram of an object is also described.
Abstract translation: 一种物体的全息图的制造装置，包括朝向物体发出非相干电磁波的光源，以及配置为显示掩模的掩模装置，接收朝向物体发射的非相干电磁波，对接收的非相干电磁波进行掩模， 到显示的掩模，并产生掩蔽的电磁波。 该装置还包括被配置为捕获被屏蔽的电磁波的图像的图像记录装置，以及被配置为将被屏蔽的电磁波的图像转换成对象的全息图的处理装置。 还描述了用于产生物体的全息图的方法。
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Patent Agency Ranking
6.发明申请METHOD AND SYSTEM FOR WIDE-FIELD MULTI-PHOTON MICROSCOPY HAVING A CONFOCAL EXCITATION PLANE 审中-公开具有共焦激发平面的宽域多光子显微镜的方法与系统公开(公告)号：US20080116392A1
公开(公告)日：2008-05-22
申请号：US11561766
申请日：2006-11-20
Applicant: Gary Brooker
Inventor： Gary Brooker
CPC classification number: G02B21/0076
Abstract: A wide field microscope includes a stage configured to hold a specimen having a fluorescent material therein, and a multi-photon excitation light source configured to produce excitation light having a single photon energy less than an absorption energy required for single photon excitation of said fluorescent material. A beam expansion unit is optically coupled to the light source and configured to expand the excitation light with reduced pulse spreading characteristics, and an infinity corrected objective optically coupled to the expansion unit and configured to focus the excitation light onto the specimen such that multi-photon excitation of the fluorescent material simultaneously occurs over a predetermined area of the specimen. A focus lens is configured to focus emission light emitted from said predetermined area of the specimen onto at least two pixels of an image detector simultaneously.
Abstract translation: 宽场显微镜包括配置成保持其中具有荧光材料的样本的台和配置为产生具有小于所述荧光材料的单光子激发所需的吸收能量的单光子能量的激发光的多光子激发光源 。 光束扩展单元光学耦合到光源并且被配置为以减小的脉冲扩展特性来扩展激发光;以及无穷远校正对象，光学耦合到扩展单元并且被配置为将激发光聚焦到样本上，使得多光子 荧光材料的激发同时发生在样品的预定区域上。 焦点透镜被配置为将从样本的所述预定区域发射的发射光同时聚焦到图像检测器的至少两个像素。
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公开(公告)号：US11698606B2
公开(公告)日：2023-07-11
申请号：US14680777
申请日：2015-04-07
Applicant: CellOptic, Inc.
Inventor： Joseph Rosen , Gary Brooker
CPC classification number: G03H1/06 , G03H1/0005 , G03H1/0443 , G03H1/08 , G03H5/00 , G02B5/32 , G03H1/0244 , G03H2001/0033 , G03H2001/0066 , G03H2001/0447 , G03H2001/0458 , G03H2222/24 , G03H2223/12 , G03H2223/13 , G03H2225/33 , G03H2240/13 , G03H2240/24
Abstract: An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.
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公开(公告)号：US20220020116A1
公开(公告)日：2022-01-20
申请号：US17379672
申请日：2021-07-19
Applicant: CELLOPTIC, INC.
Inventor： Nisan SIEGEL , Gary Brooker
Abstract: An advance in ultra-high-resolution optical imaging has been achieved by the introduction of iterative high-resolution image-building algorithms to incoherent holography. A recorded FINCH hologram is used as the basis of a method in which a high resolution image is built using detailed knowledge of the point spread functions of the FINCH hologram or reconstructed image, and then iteratively improved by successive algorithm generations of comparison to the recorded FINCH hologram and alteration of the high resolution image.
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公开(公告)号：US11209776B2
公开(公告)日：2021-12-28
申请号：US16816949
申请日：2020-03-12
Applicant: CellOptic, Inc.
Inventor： Gary Brooker , Nisan Siegel
IPC: G03H1/04 , G02B5/30 , G03H1/06 , G02B3/08 , G03H1/00 , A61B3/13 , G02B1/02 , G02B21/00 , G03H1/08
Abstract: Techniques to improve image quality in holography utilizing lenses made from materials with non-quantized anisotropic electromagnetic properties, such as birefringent materials, to advantageously split an incoming beam of light into two coincident beams with different focal lengths that interfere with one another and thus create holograms free of electro-optical or pixelated devices are disclosed for microscopy and other applications. The use of thin birefringent lenses and single crystal alpha-BBO lenses are introduced. Corresponding systems, methods and apparatuses are described.
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10.发明授权公开(公告)号：US09891585B2
公开(公告)日：2018-02-13
申请号：US15026785
申请日：2014-09-29
Applicant: Gary Brooker
Inventor： Gary Brooker , Nisan Siegel , Joseph Rosen
CPC classification number: G03H1/0443 , G02B21/0068 , G02B21/16 , G03H1/041 , G03H1/06 , G03H5/00 , G03H2001/005 , G03H2001/0447 , G03H2001/0452 , G03H2222/24 , G03H2222/31 , G03H2223/22 , G03H2225/22
Abstract: A new optical arrangement that creates high efficiency, high quality Fresnel Incoherent Correlation Holography (FINCH) holograms using transmission liquid crystal GRIN (TLCGRIN) diffractive lenses has been invented. This is in contrast to the universal practice in the field of using a reflective spatial light modulator (SLM) to separate sample and reference beams. Polarization sensitive TLCGRIN lenses enable a straight optical path, have 95% transmission efficiency, are analog devices without pixels and are free of many limitations of reflective SLM devices. An additional advantage is that they create an incoherent holographic system that is achromatic over a wide bandwidth. Two spherical beams created by the combination of a glass and a polarization sensitive TLCGRIN lenses interfere and a hologram is recorded by a digital camera. FINCH configurations which increase signal to noise ratios and imaging speed are also described.
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