公开(公告)号：US5415872A

公开(公告)日：1995-05-16

申请号：US140217

申请日：1993-10-20

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/575

CPC分类号： A61K31/575 ,  A61K9/1605 ,  A61K9/5042

摘要： Disclosed are buffer-stabilized gastric acid resistant polymer-coated bile salt compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, preventing colon cancer, cholestasis associated with cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.

摘要翻译： 公开了缓冲液稳定的耐胃酸聚合物包被的胆汁盐组合物，其制备方法和治疗消化系统疾病，肝脏功能受损，肝脏和胆道自身免疫性疾病，预防结肠癌，与囊性纤维化相关的胆汁郁积，溶解 胆固醇并通过将所述组合物施用于需要这种治疗的哺乳动物来调节膳食胆固醇的吸收。

公开(公告)号：US5262172A

公开(公告)日：1993-11-16

申请号：US901749

申请日：1992-06-19

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/54 ,  A61K9/58 ,  A61K9/62 ,  A61K31/575

CPC分类号： A61K9/5042 ,  A61K31/575 ,  A61K9/1605 ,  A61K9/1611 ,  Y10S514/867 ,  Y10S514/877 ,  Y10S514/893

摘要： Disclosed are gastric acid-resistant polymer-coated buffered-bile acid compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.

公开(公告)号：US5234697A

公开(公告)日：1993-08-10

申请号：US902578

申请日：1992-06-22

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/575

CPC分类号： A61K31/575 ,  A61K9/1605 ,  A61K9/5042

摘要： Disclosed are gastric acid-resistant polymer-coated ursodeoxycholate compositions, process for their preparations and-methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.

摘要翻译： 公开了耐胃酸聚合物包被的熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病，肝脏功能受损，肝脏和胆道自身免疫性疾病，预防胆囊切除术后的结肠癌，囊性纤维化，溶解胆结石和 通过将所述组合物施用于需要这种治疗的哺乳动物来调节膳食胆固醇的吸收。

公开(公告)号：US5614223A

公开(公告)日：1997-03-25

申请号：US503202

申请日：1995-07-17

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K6/00 ,  A61K8/11 ,  A61K9/00 ,  A61K9/16 ,  A61K9/52 ,  A61Q11/00 ,  A61K9/14

CPC分类号： A61Q11/00 ,  A61K6/0008 ,  A61K6/0017 ,  A61K6/0067 ,  A61K8/11 ,  A61K9/0063 ,  A61K2800/412

摘要： Disclosed are controlled rate-release devices for releasing a pharmaceutically active agent into the oral cavity by the dissolving action of the saliva, a process of preparing such devices and methods of preventing/treating conditions/diseases in a mammal by delivering a pharmaceutically active substance into the oral cavity.

摘要翻译： 公开了用于通过唾液的溶解作用将药物活性剂释放到口腔中的控制速率释放装置，制备这种装置的方法以及通过将药物活性物质递送到哺乳动物中来预防/治疗病症/疾病的方法 口腔。

公开(公告)号：US5578304A

公开(公告)日：1996-11-26

申请号：US434953

申请日：1995-05-04

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/46 ,  A61K38/43 ,  A61K38/48 ,  A61K38/54

CPC分类号： A61K31/575 ,  A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  A61K45/06 ,  A61K9/1605 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073

摘要： Disclosed are gastric acid-resistant polymer-coated, buffered digestive enzymes/ursodeoxycholate compositions, process for their preparations and methods for treating digestive disorders, pancreatic enzyme insufficiency, impaired liver function, and cystic fibrosis for regulating the absorption of dietary iron and cholesterol, and for dissolving gallstones by administering the compositions to a mammal in need of such treatment.

摘要翻译： 公开了耐胃酸聚合物包被的缓冲消化酶/熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病的方法，胰腺酶功能不全，肝功能受损，以及用于调节膳食铁和胆固醇吸收的囊性纤维化，以及 用于通过将所述组合物施用于需要这种治疗的哺乳动物来溶解胆结石。

公开(公告)号：US5460812A

公开(公告)日：1995-10-24

申请号：US129250

申请日：1993-09-29

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/46 ,  A61K38/43 ,  A61K38/48 ,  A61K38/54

CPC分类号： A61K38/48 ,  A61K38/465 ,  A61K38/47 ,  A61K9/1605 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073

摘要： Disclosed are gastric acid-resistant polymer-coated buffered digestive enzymes/ursodeoxycholate compositions, process for their preparations and methods of treating digestive disorders, pancreatic enzyme insufficiency, impaired liver function, cystic fibrosis, for regulating the absorption of dietary iron and cholesterol, and for dissolving gallstones by administering the compositions to a mammal in need of such treatment.

摘要翻译： 公开了耐胃酸聚合物包被的缓冲消化酶/熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病的方法，胰腺酶功能不全，肝功能受损，囊性纤维化，调节膳食铁和胆固醇的吸收，以及 通过将该组合物给予需要这种治疗的哺乳动物来溶解胆结石。

公开(公告)号：US5433952A

公开(公告)日：1995-07-18

申请号：US109632

申请日：1993-08-20

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K6/00 ,  A61K8/11 ,  A61K9/00 ,  A61K9/22 ,  A61K9/32 ,  A61Q11/00 ,  A61K9/14

CPC分类号： A61Q11/00 ,  A61K6/0023 ,  A61K6/0067 ,  A61K8/11 ,  A61K9/0063 ,  A61K2800/412

摘要： Disclosed are controlled rate-release devices for releasing a pharmaceutically active agent into the oral cavity by the dissolving action of the saliva, and a method of preparing such devices.

摘要翻译： 公开了用于通过唾液的溶解作用将药物活性剂释放到口腔中的控制速率释放装置，以及制备这种装置的方法。

公开(公告)号：US5352682A

公开(公告)日：1994-10-04

申请号：US27693

申请日：1993-03-08

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K31/60 ,  A61K31/56

CPC分类号： A61K31/60

摘要： Disclosed are compositions containing bile acid-aminosalicylate conjugates having the formula, or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.1 is OH either the .alpha. or the .beta. position;R.sub.2 is OH;R.sub.3 is H or OH; andR.sub.4 is H or acetyl,the process for their preparation and method of treating/preventing gastrointestinal disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, colon cancer, inflammatory bowel diseases, Crohn's disease, cystic fibrosis, dissolving gallstones, and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.

摘要翻译： 公开了含有下式的胆汁酸 - 氨基水杨酸缀合物或其药学上可接受的盐的组合物：其中R1是OH或α位置; R2是OH; R3是H或OH; R4为H或乙酰基，其制备方法及治疗/预防胃肠道疾病，肝功能受损，肝胆自身免疫性疾病，结肠癌，炎性肠病，克罗恩病，囊性纤维化，溶解性胆结石， 并通过向需要这种治疗的哺乳动物施用所述组合物来调节膳食胆固醇吸收。

公开(公告)号：US5352460A

公开(公告)日：1994-10-04

申请号：US65780

申请日：1993-05-24

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/575

CPC分类号： A61K31/575 ,  A61K9/1605 ,  A61K9/5042

摘要： Disclosed are gastric acid-resistant polymer-coated ursodeoxycholate compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.

摘要翻译： 公开了耐胃酸聚合物包被的熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病，肝脏功能受损，肝脏和胆道自身免疫性疾病，预防胆囊切除术后的结肠癌，囊性纤维化，溶解胆结石和调节 通过向需要这种治疗的哺乳动物施用所述组合物来饮食胆固醇吸收。

公开(公告)号：US5260074A

公开(公告)日：1993-11-09

申请号：US901734

申请日：1992-06-22

申请人： Tibor Sipos

发明人： Tibor Sipos

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/46 ,  A61K37/48 ,  A61K37/62 ,  C12N9/76

CPC分类号： A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  A61K9/1605 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073

摘要： Disclosed are gastric acid-resistant polymer-coated digestive enzymes/ursodeoxycholate compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, cystic fibrosis, regulating the absorption of dietary cholesterol, and for dissolving gallstones by administering the compositions to a mammal in need of such treatment.