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公开(公告)号：US5433952A
公开(公告)日：1995-07-18
申请号：US109632
申请日：1993-08-20
申请人： Tibor Sipos
发明人： Tibor Sipos
CPC分类号： A61Q11/00 , A61K6/0023 , A61K6/0067 , A61K8/11 , A61K9/0063 , A61K2800/412
摘要： Disclosed are controlled rate-release devices for releasing a pharmaceutically active agent into the oral cavity by the dissolving action of the saliva, and a method of preparing such devices.
摘要翻译： 公开了用于通过唾液的溶解作用将药物活性剂释放到口腔中的控制速率释放装置，以及制备这种装置的方法。
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2.发明授权
公开(公告)号：US5352682A
公开(公告)日：1994-10-04
申请号：US27693
申请日：1993-03-08
申请人： Tibor Sipos
发明人： Tibor Sipos
CPC分类号： A61K31/60
摘要： Disclosed are compositions containing bile acid-aminosalicylate conjugates having the formula, or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.1 is OH either the .alpha. or the .beta. position;R.sub.2 is OH;R.sub.3 is H or OH; andR.sub.4 is H or acetyl,the process for their preparation and method of treating/preventing gastrointestinal disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, colon cancer, inflammatory bowel diseases, Crohn's disease, cystic fibrosis, dissolving gallstones, and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.
摘要翻译： 公开了含有下式的胆汁酸 - 氨基水杨酸缀合物或其药学上可接受的盐的组合物：其中R1是OH或α位置; R2是OH; R3是H或OH; R4为H或乙酰基，其制备方法及治疗/预防胃肠道疾病，肝功能受损，肝胆自身免疫性疾病，结肠癌，炎性肠病，克罗恩病，囊性纤维化，溶解性胆结石， 并通过向需要这种治疗的哺乳动物施用所述组合物来调节膳食胆固醇吸收。
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3.发明授权
公开(公告)号：US5352460A
公开(公告)日：1994-10-04
申请号：US65780
申请日：1993-05-24
申请人： Tibor Sipos
发明人： Tibor Sipos
IPC分类号： A61K9/16 , A61K9/50 , A61K31/575
CPC分类号： A61K31/575 , A61K9/1605 , A61K9/5042
摘要： Disclosed are gastric acid-resistant polymer-coated ursodeoxycholate compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.
摘要翻译： 公开了耐胃酸聚合物包被的熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病，肝脏功能受损，肝脏和胆道自身免疫性疾病，预防胆囊切除术后的结肠癌，囊性纤维化，溶解胆结石和调节 通过向需要这种治疗的哺乳动物施用所述组合物来饮食胆固醇吸收。
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4.发明授权
公开(公告)号：US5260074A
公开(公告)日：1993-11-09
申请号：US901734
申请日：1992-06-22
申请人： Tibor Sipos
发明人： Tibor Sipos
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , A61K9/1605 , A61K9/5026 , A61K9/5042 , A61K9/5073
摘要： Disclosed are gastric acid-resistant polymer-coated digestive enzymes/ursodeoxycholate compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, cystic fibrosis, regulating the absorption of dietary cholesterol, and for dissolving gallstones by administering the compositions to a mammal in need of such treatment.
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公开(公告)号：US5049077A
公开(公告)日：1991-09-17
申请号：US325815
申请日：1989-03-20
CPC分类号： A61C19/06 , A61J7/0092 , A61C7/00
摘要： A system for long term releasing of medication in the mouth, and especially an intra-oral fluoride releasing system (IFRS) for releasing fluoride over a long term for inhibiting the formation of caries in the teeth. The system uses a holder for retaining and protecting intra-oral fluoride tablets or other intra-oral medicament in the form of fluoride releasing devices (IFRD). The holder has a plate with retaining sides and retaining posts or a carrier. The tablet will fit within the holder. The tablet may be located in the carrier, or ligature bands can be tied around the tablet in order to releasably hold the IFRD within the holder. The system causes a level of fluoride to be maintained over a long term within the mouth which has been found chemically effective for caries control and without causing severe irritation to oral tissues.
摘要翻译： 一种用于长期释放口服药物的系统，特别是用于长期释放氟化物的口服内氟化物释放系统（IFRS），用于抑制牙齿中龋齿的形成。 该系统使用保持器并保护氟化物释放装置（IFRD）形式的口服内氟化物片剂或其它口服内药物。 支架具有带有保持边和支柱或支架的板。 平板电脑将适合持有人。 片剂可以位于载体中，或者连接带可以围绕片剂绑扎，以便可释放地将IFRD保持在保持器内。 该系统使得在口腔内长期保持一定程度的氟化物，其已被发现对于龋齿控制具有化学有效性，并且不会对口腔组织造成严重刺激。
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6.发明授权
公开(公告)号：US4477429A
公开(公告)日：1984-10-16
申请号：US412331
申请日：1982-08-26
申请人： Steven B. Silbering , Tibor Sipos
发明人： Steven B. Silbering , Tibor Sipos
IPC分类号： A61K8/44 , A61Q11/00 , A61K7/22 , C07C129/12
摘要： Oral hygiene formulations incorporating N.sup..alpha. -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
摘要翻译： 包含精氨酸的Nα - 烷基衍生物或其药学上可接受的盐，任选与氟化合物组合的口腔卫生制剂在对抗微生物，抑制酸产生和减少龋齿方面是有效的。
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7.发明授权Oral compositions comprising N.sup..alpha.,N.sup.G -diacyl derivatives of arginine 失效包含精氨酸的Nα，NG-二酰基衍生物的口服组合物
公开(公告)号：US4477428A
公开(公告)日：1984-10-16
申请号：US412041
申请日：1982-08-26
申请人： Steven B. Silbering , Tibor Sipos
发明人： Steven B. Silbering , Tibor Sipos
IPC分类号： A61K8/44 , A61Q11/00 , A61K7/22 , C07C129/12
摘要： Oral hygiene formulations incorporating N.sup..alpha.,N.sup.G -diacyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
摘要翻译： 含有精氨酸的Nα，NG-二酰基衍生物或其药学上可接受的盐，任选与氟化合物组合的口腔卫生制剂，有效地对抗微生物，抑制酸产生和减少龋齿。
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8.发明授权
公开(公告)号：US5262172A
公开(公告)日：1993-11-16
申请号：US901749
申请日：1992-06-19
申请人： Tibor Sipos
发明人： Tibor Sipos
CPC分类号： A61K9/5042 , A61K31/575 , A61K9/1605 , A61K9/1611 , Y10S514/867 , Y10S514/877 , Y10S514/893
摘要： Disclosed are gastric acid-resistant polymer-coated buffered-bile acid compositions, process for their preparations and methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.
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9.发明授权
公开(公告)号：US5234697A
公开(公告)日：1993-08-10
申请号：US902578
申请日：1992-06-22
申请人： Tibor Sipos
发明人： Tibor Sipos
IPC分类号： A61K9/16 , A61K9/50 , A61K31/575
CPC分类号： A61K31/575 , A61K9/1605 , A61K9/5042
摘要： Disclosed are gastric acid-resistant polymer-coated ursodeoxycholate compositions, process for their preparations and-methods of treating digestive disorders, impaired liver function, autoimmune diseases of the liver and biliary tract, prevention of colon cancer following cholecystectomy, cystic fibrosis, dissolving gallstones and regulating dietary cholesterol absorption by administering said compositions to a mammal in need of such treatment.
摘要翻译： 公开了耐胃酸聚合物包被的熊去氧胆酸盐组合物，其制备方法和治疗消化系统疾病，肝脏功能受损，肝脏和胆道自身免疫性疾病，预防胆囊切除术后的结肠癌，囊性纤维化，溶解胆结石和 通过将所述组合物施用于需要这种治疗的哺乳动物来调节膳食胆固醇的吸收。
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10.发明授权
公开(公告)号：US4499068A
公开(公告)日：1985-02-12
申请号：US412365
申请日：1982-08-26
申请人： Steven B. Silbering , Tibor Sipos
发明人： Steven B. Silbering , Tibor Sipos
IPC分类号： A61K8/34 , A61K8/44 , A61Q11/00 , C07C279/14 , C07C129/12 , A61K7/18 , A61K7/22
CPC分类号： C07C279/14 , A61K8/345 , A61K8/44 , A61Q11/00
摘要： Oral hygiene formulations incorporating N.sup.G -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
摘要翻译： 包含精氨酸的NG-烷基衍生物或其药学上可接受的盐，任选与氟化合物组合的口腔卫生制剂在对抗微生物，抑制酸产生和减少龋齿方面是有效的。
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