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1.发明公开公开(公告)号：US20240299442A1
公开(公告)日：2024-09-12
申请号：US18268371
申请日：2021-12-22
发明人： Carlo PIZZOCARO
IPC分类号： A61K31/737 , A61K31/728 , A61K47/10 , A61K47/32 , A61P31/14
CPC分类号： A61K31/737 , A61K31/728 , A61K47/10 , A61K47/32 , A61P31/14
摘要： Ester and sulfated derivatives of hyaluronic acid are described for use in the prevention and treatment of the initial stage of SARS-CoV-2 disease.
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2.发明公开公开(公告)号：US20240123077A1
公开(公告)日：2024-04-18
申请号：US18539827
申请日：2023-12-14
发明人： Giorgio MOSCONI , Daniela JABES , Carlo PIZZOCARO
IPC分类号： A61K47/61 , A61K31/337
CPC分类号： A61K47/61 , A61K31/337
摘要： A pharmaceutical composition includes a paclitaxel prodrug associated with pharmacologically acceptable diluents/excipients for use in the treatment of non-muscle invasive bladder cancer (NMIBC) by intravesical instillations according to a single weekly dose of 600 mg of the prodrug, or two weekly doses equal to a total of 1,200 mg, for 12 or 6 consecutive weeks of treatment. The paclitaxel prodrug used was prepared according to an indirect synthesis process between molecules of hyaluronic acid (HA) and paclitaxel by introducing a spacer (4-bromobutyric acid) between the hyaluronic acid and chemotherapeutic agent.
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公开(公告)号：US20220193032A1
公开(公告)日：2022-06-23
申请号：US17604142
申请日：2020-04-15
发明人： Carlo BARBERA , Andrea PASTORELLO
IPC分类号： A61K31/366 , A61K45/06 , A61K47/36 , A61K31/728
摘要： The present invention relates to pharmaceutical compositions comprising mixtures of a statin and a hyaluronic acid amide derivative which are useful in the treatment of inflammation and degradation of osteoarthritic joint cartilage, in particular post-traumatic osteoarthrosis and osteoarthrosis caused by physiological joint aging, and in the treatment of other joint disorders such as rheumatoid arthritis.
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公开(公告)号：US11197886B2
公开(公告)日：2021-12-14
申请号：US16593616
申请日：2019-10-04
摘要： The present invention discloses pharmaceutical compositions comprising ester derivatives of hyaluronic acid for use as a topical treatment in disorders of the vaginal mucosa characterised by loss of elasticity and hydration, such as vaginal dryness and/or atrophic vaginitis; said compositions can also be used successfully to lubricate the genital mucosa.
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公开(公告)号：US10548918B2
公开(公告)日：2020-02-04
申请号：US15710275
申请日：2017-09-20
IPC分类号： A61K31/737
摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and antiinflammatory) and consequently the use of HAS for the preparation of a new medicine for the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and antiinflammatory nature. The Applicant has in fact discovered its exclusive capacity in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, HIV, Cytomegalovirus and the virus of vesicular stomatitis.
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公开(公告)号：US10478413B2
公开(公告)日：2019-11-19
申请号：US15888618
申请日：2018-02-05
IPC分类号： A61K31/196 , A61K47/10 , A61K47/12 , A61K47/22 , A61K9/70
摘要： The present invention relates to a high adhesion dermal therapeutic system comprising an adhesive polymeric matrix with a salt of Diclofenac.
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公开(公告)号：US10364299B2
公开(公告)日：2019-07-30
申请号：US15500640
申请日：2015-07-30
发明人： Sebastiano Sciuto , Valentina Greco , Enrico Rizzarelli , Francesco Bellia , Valeria Lanza , Susanna Vaccaro , Luciano Messina
IPC分类号： A61K47/61 , C08B37/08 , C07D233/64
摘要： The present invention relates to a derivative of carnosine (β-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
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公开(公告)号：US10208300B2
公开(公告)日：2019-02-19
申请号：US15226593
申请日：2016-08-02
IPC分类号： C12N13/00 , C12N9/26 , C07K14/315 , C07K14/435 , A61K38/47 , A61K39/35 , A61K45/06 , A61K38/00
摘要： A process for preparing Streptomyces koganeiensis ATCC 31394 hyaluronidase by obtaining hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date.
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9.发明申请公开(公告)号：US20180360990A1
公开(公告)日：2018-12-20
申请号：US16061220
申请日：2016-12-20
发明人： Rosario Maria SANCHEZ MARTIN , Salvatore PERNAGALLO , Juan Diego UNCITI BROCETA , Luciano MESSINA , Susanna VACCARO , Laura PILOTTO
摘要： Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
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10.发明授权公开(公告)号：US10064887B2
公开(公告)日：2018-09-04
申请号：US14786126
申请日：2014-04-23
发明人： Nicola Giordan , Pierangelo Bellato
摘要： The present invention describes and claims pharmaceutical compositions in gel form for use in the treatment of intervertebral disc degeneration, in particular the forms of dehydration and emptying of the nucleus pulposus known as “black disc disease”. These compositions comprise a hyaluronic acid derivative which forms hydrogels with precise rheological characteristics that make it ideal for filling the nucleus pulposus.
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