公开(公告)号：US09956373B2

公开(公告)日：2018-05-01

申请号：US14474252

申请日：2014-09-01

申请人： GENO LLC

发明人： David P. Rounbehler ,  David H. Fine

IPC分类号： A62B7/08 ,  A61M16/12 ,  A61M16/10 ,  C01B21/24 ,  A61M15/00

CPC分类号： A61M16/122 ,  A61M15/00 ,  A61M16/10 ,  A61M2016/1025 ,  A61M2202/0275 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

公开(公告)号：US20170369316A1

公开(公告)日：2017-12-28

申请号：US15645197

申请日：2017-07-10

申请人： GENO LLC

发明人： David H. Fine ,  Gregory Vasquez ,  David P. Rounbehler

IPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/12 ,  A61M16/16 ,  A61M16/10 ,  G01N27/416 ,  C01B21/24 ,  A61M16/00

CPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/009 ,  A61M16/104 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M16/16 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24 ,  G01N27/416 ,  Y10T436/179228

摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

公开(公告)号：US09701538B2

公开(公告)日：2017-07-11

申请号：US14294070

申请日：2014-06-02

申请人： GENO LLC

发明人： David H. Fine ,  Gregory Vasquez ,  David P. Rounbehler

IPC分类号： C01B21/32 ,  A61K33/00 ,  C01B21/24 ,  A61D7/04 ,  A61M16/00 ,  A61M16/10 ,  A61M16/12 ,  A61M16/16 ,  G01N27/416

CPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/009 ,  A61M16/104 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M16/16 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24 ,  G01N27/416 ,  Y10T436/179228

摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

公开(公告)号：US20160151598A1

公开(公告)日：2016-06-02

申请号：US14948992

申请日：2015-11-23

申请人： GENO LLC

发明人： David H. Fine, I

IPC分类号： A61M16/12 ,  A61M16/10

CPC分类号： A61M16/12 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/7023 ,  A61K31/655 ,  A61K33/00 ,  A61K47/02 ,  A61M5/165 ,  A61M15/00 ,  A61M15/08 ,  A61M15/085 ,  A61M16/105 ,  A61M35/006 ,  A61M2005/006 ,  A61M2202/0275 ,  A61M2205/75

摘要： A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

摘要翻译： 将一氧化氮治疗用于对象的方法可以包括向受试者施用包含一氧化氮释放剂和二氧化硅的组合物，并从组合物中释放治疗量的一氧化氮。

公开(公告)号：US20150007814A1

公开(公告)日：2015-01-08

申请号：US14270260

申请日：2014-05-05

申请人： David H. Fine ,  David R. Rounbehler ,  Gregory Vasquez ,  Brian Johnson

发明人： David H. Fine ,  David R. Rounbehler ,  Gregory Vasquez ,  Brian Johnson

IPC分类号： A61M16/12

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

公开(公告)号：US08741222B2

公开(公告)日：2014-06-03

申请号：US14107535

申请日：2013-12-16

申请人： Geno LLC

发明人： David H. Fine ,  Gregory Vasquez ,  David P. Rounbehler

IPC分类号： A62B7/08

CPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/009 ,  A61M16/104 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M16/16 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24 ,  G01N27/416 ,  Y10T436/179228

摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

摘要翻译： 本文公开了各种系统，装置，NO 2吸收剂，NO 2清除剂和用于产生一氧化氮的NO 2还原剂。 根据一个实施方案，用于将二氧化氮转化成一氧化氮的装置可以包括容器，其包括入口，出口，涂覆有抗坏血酸水溶液的表面活性材料和吸收剂，其中所述入口构造成接收气体 通过表面活性材料和吸收剂流动并流动地将气流传递到出口，使得气流中的二氧化氮转化为一氧化氮。

公开(公告)号：US08715577B2

公开(公告)日：2014-05-06

申请号：US13436018

申请日：2012-03-30

申请人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

发明人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

IPC分类号： A62B7/08 ,  G05B1/00 ,  G05D16/00 ,  B01J19/00 ,  A61M15/00 ,  A61M16/00 ,  A61M16/10 ,  A62B7/10 ,  A62B23/02

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

公开(公告)号：US08371296B2

公开(公告)日：2013-02-12

申请号：US11382116

申请日：2006-05-08

申请人： David H. Fine ,  Stephen J. MacDonald ,  David Rounbehler ,  David Wheeler ,  Jonathan L. Rolfe ,  George Jarvis

发明人： David H. Fine ,  Stephen J. MacDonald ,  David Rounbehler ,  David Wheeler ,  Jonathan L. Rolfe ,  George Jarvis

IPC分类号： A61M16/00

CPC分类号： A61K9/007 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/7007 ,  A61K33/00 ,  A61K33/24 ,  A61K33/30 ,  A61K33/34 ,  A61M16/10 ,  A61M16/12 ,  A61M2016/1035 ,  A61M2202/0275 ,  A61M2209/06 ,  C01B21/24

摘要： Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.

公开(公告)号：US08173072B2

公开(公告)日：2012-05-08

申请号：US12563662

申请日：2009-09-21

申请人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

发明人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

IPC分类号： B01J19/00 ,  A61M15/00 ,  A61M16/10 ,  A61M16/00 ,  A62B7/10 ,  A62B23/02

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

公开(公告)号：US07914743B2

公开(公告)日：2011-03-29

申请号：US12361274

申请日：2009-01-28

申请人： David Fine ,  Gregory Vasquez ,  David P. Rounbehler

发明人： David Fine ,  Gregory Vasquez ,  David P. Rounbehler

IPC分类号： A62B7/08

CPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/009 ,  A61M16/104 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M16/16 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24 ,  G01N27/416 ,  Y10T436/179228

摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

摘要翻译： 本文公开了各种系统，装置，NO 2吸收剂，NO 2清除剂和用于产生一氧化氮的NO 2还原剂。 根据一个实施方案，用于将二氧化氮转化成一氧化氮的装置可以包括容器，其包括入口，出口，涂覆有抗坏血酸水溶液的表面活性材料和吸收剂，其中所述入口构造成接收气体 通过表面活性材料和吸收剂流动并流动地将气流传递到出口，使得气流中的二氧化氮转化为一氧化氮。