公开(公告)号：US20140275870A1

公开(公告)日：2014-09-18

申请号：US13835143

申请日：2013-03-15

申请人： Hannu HARJUNMAA ,  Rebecca Burrell ,  Stevan Kun

发明人： Hannu HARJUNMAA ,  Rebecca Burrell ,  Stevan Kun

IPC分类号： A61B5/1455 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0205

CPC分类号： A61B5/1455 ,  A61B5/0004 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/1495

摘要： A method may include directing a radiation beam at a sample, the beam including two periods of radiation having different wavelengths, an analyte in a fluid within the sample having different absorption coefficients for the two different wavelengths, detecting the beam with a detector when the sample is in a first fluid state, the detector configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths, detecting the beam with the detector when the sample is in a second fluid state, the sample transitioning from the first fluid state to the second fluid state by a pulsation of the sample, obtaining estimates of an amount of fluid at the first and second fluid states, and determining an analyte concentration estimate based on the output signal and the estimate of the amount of fluid at the first and second fluid states.

摘要翻译： 方法可以包括在样品处引导辐射束，所述束包括具有不同波长的两个辐射周期，样品内的流体中的分析物对于两个不同波长具有不同的吸收系数，当样品 处于第一流体状态，检测器被配置为产生与两个不同波长中的每一个处的波束的强度成比例的输出信号，当样品处于第二流体状态时，检测器与检测器检测波束，样品从 通过样品的脉动将第一流体状态转换到第二流体状态，获得在第一和第二流体状态下的流体量的估计，以及基于输出信号和流体量的估计来确定分析物浓度估计 在第一和第二流体状态。

公开(公告)号：US08175666B2

公开(公告)日：2012-05-08

申请号：US11526564

申请日：2006-09-25

申请人： Hannu Harjunmaa ,  Stevan Kun ,  Rebecca Burrell ,  Georg Leuenberger

发明人： Hannu Harjunmaa ,  Stevan Kun ,  Rebecca Burrell ,  Georg Leuenberger

IPC分类号： A61B5/1455

CPC分类号： G01N21/3151 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/35 ,  G01N21/49

摘要： An improved method for non-invasively measuring a concentration of a target analyte dissolved in a fluid flowing through a sample is presented. It includes directing a probe beam of electromagnetic radiation, having time multiplexed components of different wavelengths, where at least one of the time-multiplexed components consists of two different simultaneous wavelengths through the sample and measuring the difference of the absorption of the radiation of the time-multiplexed components at different sample states. During sample state changes, the amount of fluid containing the target analyte within the sample is changing, varying the total amount of target analyte in the sample, and the absorption properties of the sample. The sample states may be produced by compressing and uncompressing the tissue sample. The method is useful in measuring the concentration of a target analyte, such as glucose, in tissue containing blood.

摘要翻译： 提出了一种用于非侵入性地测量溶解在流过样品的流体中的目标分析物的浓度的改进方法。 它包括引导具有不同波长的时间复用分量的电磁辐射的探测光束，其中至少一个时间复用分量由通过样本的两个不同的同时波长组成，并测量时间的辐射的吸收差 在不同的样品状态下复用的组件。 在样品状态变化期间，样品内含有目标分析物的流体量发生变化，改变样品中目标分析物的总量和样品的吸收性能。 可以通过压缩和解压缩组织样品来产生样品状态。 该方法可用于在含有血液的组织中测量目标分析物（例如葡萄糖）的浓度。

公开(公告)号：US20160206231A1

公开(公告)日：2016-07-21

申请号：US14601395

申请日：2015-01-21

申请人： Grove Instruments, Inc.

发明人： Stevan Kun ,  Hannu Harjunmaa ,  Rebecca Burrell

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61B5/7246 ,  A61B5/02422 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B2562/0238

摘要： A noninvasive method for estimating a concentration of a target analyte in a sample comprises generating a first and second (reference) radiation, a principal radiation and a target analyte carrier detection radiation; directing the first, second, principal and the target analyte carrier detection radiations at the sample which includes the target analyte; and detecting a first, second, principal and target analyte carrier detection amount of the radiation that leaves the sample. The method further comprises modulating the sample thickness in order to achieve time-wise or spatial target analyte concentration variation within the sample. The method further comprises generating first, second, principal and target analyte carrier detection measurement data based respectively on the first, second, the principal and the target analyte carrier detected amounts of radiation; numerically processing the first, second, principal and target analyte carrier detection measurement data to obtain a weighted combination of the first measurement data and the second measurement data that balances the principal measurement data with respect to a sample background; and estimating the concentration of the target analyte based on the difference between the balanced weighted combination of the first measurement data and the second measurement data vs. the principal measurement data.

摘要翻译： 用于估计样品中目标分析物浓度的非侵入性方法包括产生第一和第二（参考）辐射，主辐射和目标分析物载体检测辐射; 在包括目标分析物的样品上引导第一，第二，主要和目标分析物载体检测辐射; 以及检测离开样品的辐射的第一，第二主要和目标分析物载体检测量。 该方法还包括调制样品厚度以实现样品内的时间或空间目标分析物浓度变化。 该方法还包括分别基于第一，第二，主要和目标分析物载体检测的辐射量产生第一，第二，主要和目标分析物载体检测测量数据; 数字处理第一，第二主要和目标分析物载体检测测量数据，以获得第一测量数据和第二测量数据的加权组合，该第一测量数据和第二测量数据相对于样本背景平衡主测量数据; 并且基于第一测量数据的平衡加权组合与第二测量数据与主测量数据之间的差异来估计目标分析物的浓度。