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公开(公告)号：US20120328581A1
公开(公告)日：2012-12-27
申请号：US13548964
申请日：2012-07-13
申请人： Mike LEEK
发明人： Mike LEEK
CPC分类号： C12N5/0656 , A61K8/02 , A61K8/985 , A61K35/12 , A61K2800/91 , A61L27/3804 , A61L27/60 , A61L2400/06 , A61Q19/00
摘要： According to the invention there is provided a cosmetic method for the augmentation of subcutaneous or dermal tissue in a subject, which method comprises the steps of:(i) providing a suspension of autologous dermal fibroblasts; and(ii) injecting an effective volume of the suspension into tissue subadjacent to the subcutaneous or dermal tissue so that the tissue is augmented;wherein the fibroblasts are suspended in HYPOTHERMOSOL®, preferably HYPOTHERMOSOL®FRS.
摘要翻译： 根据本发明，提供了一种用于增加受试者皮下或皮肤组织的化妆方法，该方法包括以下步骤：（i）提供自体真皮成纤维细胞的悬浮液; 和（ii）将有效体积的悬浮液注射到与皮下或皮肤组织相邻的组织中，使得组织被增强; 其中成纤维细胞悬浮于HYPOTHERMOSOL®，优选HYPOTHERMOSOL®FRS中。
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公开(公告)号：US09271923B2
公开(公告)日：2016-03-01
申请号：US13791177
申请日：2013-03-08
申请人： Intercytex Limited
CPC分类号： A61K8/981 , A61K8/985 , A61K2800/91 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/58 , A61L27/60 , A61Q19/08
摘要： The present invention provides a method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject. By injecting a suspension of allogeneic cells, the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials such as autologous fibroblasts cells or collagen.According to a first aspect of the invention there is provided a method for the augmentation of subcutaneous or dermal tissue in a subject, which method comprises the steps of: (i) providing a suspension of allogeneic dermal fibroblasts; and (ii) injecting an effective volume of the suspension into tissue subadjacent to the subcutaneous or dermal tissue so that the tissue is augmented. The method is preferably cosmetic.
摘要翻译： 本发明提供了修复受试者皮下或皮肤组织的方法，其包括在一方面将同种异体真皮成纤维细胞的悬浮液注射入受试者。 通过注射同种异体细胞的悬浮液，本发明提供了例如长期增加下面的组织，而不伴随着制备和/或使用目前可获得的材料如自体成纤维细胞细胞或胶原蛋白的缺点。 根据本发明的第一方面，提供了一种用于增加受试者皮下或皮肤组织的方法，该方法包括以下步骤：（i）提供同种异体真皮成纤维细胞的悬浮液; 和（ii）将有效体积的悬浮液注射到与皮下或皮肤组织相邻的组织中，使得组织被增强。 该方法优选为化妆品。
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公开(公告)号：US20070255254A1
公开(公告)日：2007-11-01
申请号：US11787340
申请日：2007-04-16
申请人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
发明人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
IPC分类号： A61K35/36
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.
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公开(公告)号：US20130224158A1
公开(公告)日：2013-08-29
申请号：US13791177
申请日：2013-03-08
申请人： INTERCYTEX LIMITED
CPC分类号： A61K8/981 , A61K8/985 , A61K2800/91 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/58 , A61L27/60 , A61Q19/08
摘要： The present invention provides a method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject. By injecting a suspension of allogeneic cells, the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials such as autologous fibroblasts cells or collagen.According to a first aspect of the invention there is provided a method for the augmentation of subcutaneous or dermal tissue in a subject, which method comprises the steps of: (i) providing a suspension of allogeneic dermal fibroblasts; and (ii) injecting an effective volume of the suspension into tissue subadjacent to the subcutaneous or dermal tissue so that the tissue is augmented. The method is preferably cosmetic.
摘要翻译： 本发明提供了修复受试者皮下或皮肤组织的方法，其包括在一方面将同种异体真皮成纤维细胞的悬浮液注射入受试者。 通过注射同种异体细胞的悬浮液，本发明提供了例如长期增加下面的组织，而不伴随着制备和/或使用目前可获得的材料如自体成纤维细胞细胞或胶原蛋白的缺点。 根据本发明的第一方面，提供了一种用于增加受试者皮下或皮肤组织的方法，该方法包括以下步骤：（i）提供同种异体真皮成纤维细胞的悬浮液; 和（ii）将有效体积的悬浮液注射到与皮下或皮肤组织相邻的组织中，使得组织被增强。 该方法优选为化妆品。
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公开(公告)号：US20070253939A1
公开(公告)日：2007-11-01
申请号：US11787273
申请日：2007-04-16
申请人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
发明人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.
摘要翻译： 使用药物和/或头发移植手术治疗秃发或脱发。 本发明涉及一种治疗秃发的改进方法。 在一个方面，提供了一种用于在位于外皮表面下面的真皮层中诱导毛囊形成的方法，其包括使用受控输送装置将诱导性皮肤鞘细胞和/或诱导性真皮乳头细胞直接递送到真皮层中。 感应细胞的传送不需要进入预先存在的毛孔。 用于治疗秃发的受控递送装置的使用是本发明的另一方面。
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公开(公告)号：US20030161815A1
公开(公告)日：2003-08-28
申请号：US10074221
申请日：2002-02-12
申请人： Intercytex Limited
IPC分类号： A61K007/06
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： The present invention provides a method for inducing organ or tissue formation by delivering inductive cells into an organ or tissue regenerative cellular environment using a controlled delivery device. For the regeneration of hair, the method includes inducing hair follicle formation by delivering inductive cells into a dermal layer using a controlled delivery device. The present invention further provides a method for using a controlled delivery device for the delivery of inductive cells into an organ or tissue regenerative cellular environment to induce organ or tissue formation. The method for using the controlled delivery device includes delivering inductive cells into a dermal layer to induce hair follicle formation.
摘要翻译： 本发明提供了一种通过使用受控递送装置将感应细胞递送到器官或组织再生细胞环境中来诱导器官或组织形成的方法。 为了再生毛发，该方法包括通过使用受控递送装置将感应细胞递送到真皮层来诱导毛囊形成。 本发明还提供一种使用受控递送装置将感应细胞递送到器官或组织再生细胞环境中以诱导器官或组织形成的方法。 使用受控递送装置的方法包括将感应细胞递送到真皮层中以诱导毛囊形成。
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