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公开(公告)号：US12115247B2
公开(公告)日：2024-10-15
申请号：US16486447
申请日：2018-02-16
发明人： Denise Steiner , Arno Kwade
CPC分类号： A61K9/0056 , A61K9/70 , A61K47/32 , A61K47/38
摘要： Disclosed is a method for producing a porous orodispersible film, having the following steps: i) forming a suspension of a pharmaceutically acceptable solvent, a pharmaceutically acceptable matrix material, and a pharmaceutically acceptable binder, said solvent being selected such that the pharmaceutically acceptable matrix material substantially does not dissolve in it, whereas the pharmaceutically acceptable binder is dissolved in the solvent, ii) casting the suspension onto a neutral support, thereby forming a wet film, and iii) drying the wet film and obtaining a dry film. The films produced in this manner have a closed surface on the lower face whereas the upper face is porous, thereby allowing the application of a pharmaceutically active ingredient in the form of a suspension or a solution for example. This allows the active ingredient quantity to be adjusted individually to the particular application and produces a film base material which is suitable for the application of different active ingredients.
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公开(公告)号：US20240285771A1
公开(公告)日：2024-08-29
申请号：US18692408
申请日：2022-09-06
摘要： The invention relates to an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one polyvinyl alcohol having a low average molecular weight and at least one polyvinyl alcohol having a high average molecular weight and at least one pharmaceutical active substance. The invention also relates to the use of the oral thin film as a medicine.
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公开(公告)号：US20240285546A1
公开(公告)日：2024-08-29
申请号：US17786217
申请日：2020-10-02
发明人： Patrick MOHR , René RIETSCHER , René EIFLER , Olga BOURQUAIN
IPC分类号： A61K9/70 , A61K9/00 , A61K31/165 , A61K47/32 , A61P25/24
CPC分类号： A61K9/7069 , A61K9/0014 , A61K31/165 , A61K47/32 , A61P25/24
摘要： The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of agomelatine comprising a self-adhesive layer structure containing a therapeutically effective amount of agomelatine, such agomelatine TTS for use in a method of treatment, a method of treatment comprising applying such agomelatine TTS, and processes of manufacture of such TTS.
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4.发明授权公开(公告)号：US11992561B2
公开(公告)日：2024-05-28
申请号：US17900616
申请日：2022-08-31
发明人： Markus Müller , Mario Ficker , Michael Linn , Florian Hammes
IPC分类号： A61K9/70 , A61K9/00 , A61K31/135 , A61K47/10 , A61K47/32
CPC分类号： A61K9/7007 , A61K9/006 , A61K31/135 , A61K47/10 , A61K47/32
摘要： Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.
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5.发明公开公开(公告)号：US20240083078A1
公开(公告)日：2024-03-14
申请号：US18275694
申请日：2022-01-13
申请人： Olga Grünwald , Michael Kulik
发明人： Olga Grünwald , Michael Kulik
CPC分类号： B29C33/3878 , B29C33/40 , B29C33/42 , B29C59/026 , B29C59/046
摘要： provided is a method for manufacturing a mold element for the production of microarrays, including the following steps: (i) providing a planar base element having a first surface and a second surface opposite the first surface, (ii) providing a planar auxiliary element on the second surface, (iii) penetrating the base element from the first surface in order to form mold openings, and (iv) reversibly or non-reversibly entering the auxiliary element when penetrating the base element. Moreover, a mold element for the production of microarrays, including a planar base element having a first surface a second surface opposite the first surface, a planar auxiliary element arranged on the second surface, and several mold openings extending from the surface of the base element through the second surface of the base element.
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公开(公告)号：US20230233480A1
公开(公告)日：2023-07-27
申请号：US17769548
申请日：2020-10-21
发明人： Florian HAMMES , Anja TOMELERI , Tobias KLEUDGEN
CPC分类号： A61K9/7084 , A61K31/137 , A61K47/38 , A61K47/10 , A61K47/34 , A61K47/32 , A61F13/15 , A61F2013/0296
摘要： The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of fingolimod.
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公开(公告)号：US11690799B2
公开(公告)日：2023-07-04
申请号：US17048773
申请日：2019-04-23
发明人： Stefan Henke , Andreas Henning , Rolf Pracht , Danny Brodkorb , Sebastian Scherr
CPC分类号： A61K9/0021 , A61K38/21 , A61K47/10 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023
摘要： The present invention relates to a microneedle system (MNS) for the intradermal delivery of interferon, wherein polyvinylpyrrolidone is the major constituent of a completely soluble formulation.
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公开(公告)号：US11628141B2
公开(公告)日：2023-04-18
申请号：US16603021
申请日：2018-04-05
摘要： The invention relates to a method for producing an active substance laminate, especially an oral active substance laminate (100), having at least one active-substance-containing layer (31), which is arranged on a substrate (20), wherein the method comprises the following steps: a) providing a substrate (20) having an upper side (21) and an underside (22); b) applying an active-substance-containing mass (24) in a gap (25) formed by a first rotating roller (26) and a second rotating roller (27); c) transporting the substrate (20) to the second roller (27) by means of a third rotating roller (28) in such a way that the active-substance-containing mass (24) is applied to the upper side (21) of the substrate (20) by the second roller (27) in the form of an active-substance-containing layer (31); d) transporting an intermediate laminate (30), formed by the substrate (20) and the active-substance-containing layer (31), to a drying device (40); and e) drying the intermediate laminate (30), especially the active-substance-containing layer (31).
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公开(公告)号：US20220409533A1
公开(公告)日：2022-12-29
申请号：US17773383
申请日：2020-09-28
发明人： James Paul RONNANDER , Andreas KOCH
IPC分类号： A61K9/12 , A61K9/00 , A61K31/381 , A61K31/5386 , A61K31/196
摘要： The present invention relates to a kit, comprising at least one cold spray and at least one dosage form for transdermally administering at least one pharmaceutically active ingredient, to said kit for use in the treatment of a patient, to the use of a cold spray in order to shorten the resorption delay time in the application of a dosage form for transdermally administering at least one pharmaceutically active ingredient, and to a method for treating a patient.
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公开(公告)号：US11465311B2
公开(公告)日：2022-10-11
申请号：US16771569
申请日：2018-12-11
发明人： Bernd Grünes
摘要： The invention relates to an apparatus comprising a separating tool and comprising a counterpressure plate for producing contour geometries in adhesive-containing composite materials, wherein the separating tool can be moved in translational tool stroke directions between an inoperative position and a parting position normal to the counterpressure plate, and also to a method for producing contour geometries in adhesive-containing composite materials by means of an apparatus of this kind. The separating tool and the counterpressure plate can be actuated relative to one another by means of at least one actuator in at least one excitation direction with a ramp function and/or with a jump function. Each of these excitation directions lies in a parallel plane to a cutting edge plane of the separating tool. The present invention permits reliable separation of a stamped grid from laminate sections which remain on a carrier film.
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