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公开(公告)号：US12105272B2
公开(公告)日：2024-10-01
申请号：US17291283
申请日：2019-11-12
发明人： Jan Braun
CPC分类号： G02B21/26 , G02B21/365
摘要： A microscope system for examining a sample includes: a microscope having a movable microscope table, on which the sample to be examined is positionable; and a controller for: transmitting a first position signal to the microscope table, based on which the microscope table is movable into a first table position; causing the microscope, in a first examination step, to examine a first region of the sample associated with the first table position when the microscope table has been moved into the first table position; transmitting at least one second position signal to the microscope table, based on which the microscope table is movable into a second table position; and causing the microscope, in a second examination step chronologically following the first examination step, to examine a second region of the sample associated with the second table position when the microscope table has been moved into the second table position.
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2.发明公开公开(公告)号：US20240280798A1
公开(公告)日：2024-08-22
申请号：US18443399
申请日：2024-02-16
CPC分类号： G02B21/365 , H04N23/76 , H04N23/81
摘要： An apparatus for data processing for a digital imaging device is provided. The digital imaging device is configured to generate a digital image of a recording region by reading out, raster-element-by-raster-element, a multidimensional complete raster. The complete raster includes a plurality of raster elements. The apparatus is part of a control unit of the imaging device or is configured to be controllable by the control unit of the imaging device. The apparatus is configured to process raw image data from at least one sub-region of the complete raster that has already been read out during the reading out, generate processed image data in at least one processing step as a function of the raw image data, and make the processed image data available for display for access from outside the apparatus.
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公开(公告)号：US12066614B2
公开(公告)日：2024-08-20
申请号：US17278691
申请日：2019-09-19
发明人： Lars Friedrich
IPC分类号： G02B21/00
CPC分类号： G02B21/0036 , G02B21/0032 , G02B21/0064
摘要： A method for scanning a sample in microscopy includes generating at least three illumination spots in order to form a spot pattern that contains at least two illumination spots having a first wavelength and an illumination spot having a second wavelength that differs from the first wavelength. At least one specified region of the sample is scanned by moving the spot pattern formed by the illumination spots along a first direction for generating scan lines, which are each associated with the illumination spots of the spot pattern, and by moving the spot pattern formed by the illumination spots along a second direction for generating scan lines respectively after the scan lines.
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公开(公告)号：US20240255743A1
公开(公告)日：2024-08-01
申请号：US18424944
申请日：2024-01-29
IPC分类号： G02B21/00
CPC分类号： G02B21/0032 , G02B21/0076 , G02B21/008
摘要： A confocal microscope includes an illumination unit configured to generate an illumination light bundle, an imaging optics configured to receive detection light, a scanner configured to deflect the illumination light bundle to generate a scanning illumination and to direct the detection light into a detection beam path, a sensor disposed in the detection beam path, a pinhole diaphragm arranged in the detection beam path upstream of the sensor, an adjustable light deflector arranged in the detection beam path and configured to direct the detection light through the pinhole diaphragm onto the sensor, and a controller configured to control the scanner to adjust the confocal microscope in such a manner that the illumination light bundle is directed onto a test object, and control the light deflector in such a manner that an intensity of the detection light coming from the test object, as detected by the sensor, is optimized.
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公开(公告)号：US20240255497A1
公开(公告)日：2024-08-01
申请号：US18561777
申请日：2021-08-28
发明人： Soeren ALSHEIMER
IPC分类号： G01N33/542 , G01N33/53
CPC分类号： G01N33/542 , G01N33/5302
摘要： A method for analyzing a sample is provided. The sample includes a plurality of affinity reagents, at least one of the affinity reagents being attached to an analyte, and a first plurality of combinations of dyes. Each combination of dyes includes at least two dyes having different characteristics for at least one of excitation or emission. Each one of the unique combinations of dyes is attached to an associated affinity reagent of the plurality of affinity reagents according to a first mapping. The method includes directing excitation light at the sample, the excitation light having characteristics for exciting at least one of the at least two dyes having different characteristics, generating at least one first readout from emission light emitted by the excited dyes, and determining, by at least one computer processor, at least one affinity reagent present in the sample based on the at least one first readout.
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公开(公告)号：US12044836B2
公开(公告)日：2024-07-23
申请号：US17413611
申请日：2019-11-22
发明人： Florian Fahrbach , Werner Knebel , Ulf Schwarz
CPC分类号： G02B21/0076 , G02B21/0032 , G01N21/6458
摘要： A method for high-resolution imaging includes illuminating a target region of a specimen by first and second illumination light beams during respective holding durations to transfer respective subsets of fluorophores from a first into a second state. The fluorophores emit fluorescence photons upon transition from the second back into the first state, which are used to produce respective raw images. The illumination light beams have different power and/or beam profiles. A high-resolution image is produced from the raw images. The respective holding durations are shorter than a lifetime of a third state of the fluorophores, into which a third subset of the fluorophores is transferred by the illumination of the target region by the first and/or second illumination light beam, and the lifetime of the third state is longer by a factor of at least 2 than a lifetime of the second state.
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公开(公告)号：US20240241359A1
公开(公告)日：2024-07-18
申请号：US18562393
申请日：2022-05-23
发明人： Christian SCHUMANN
CPC分类号： G02B21/16 , G01N21/6408 , G01N21/6458 , G02B21/365
摘要： A method for examining a sample containing a target fluorophore j using a fluorescence microscope includes acquiring a series of sample images over an acquisition time interval, and adjusting an illumination parameter Pk in a plurality of iteration steps n during the acquisition time interval to different set values. The series of sample images are acquired after adjusting the illumination parameter Pk in at least some of the plurality of iteration steps n. The method further includes determining a bleaching behaviour descriptor κj indicative of a bleaching behaviour of the target fluorophore j and a fluorescence response descriptor Ij indicative of a fluorescence response of the target fluorophore j for the set values of the illumination parameter Pk. The illumination parameter Pk is adjusted based on the bleaching behaviour descriptor κj and the fluorescence response descriptor Ij as determined in a preceding one of the plurality of iteration steps n.
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公开(公告)号：US12041340B2
公开(公告)日：2024-07-16
申请号：US17610462
申请日：2020-05-12
发明人： Stefan Fabris , Patric Pelzer , Marco Bingel
摘要： A controller for providing an operational setting of an imaging device is configured to provide a user with a preferred operational setting for acquiring an image. The controller is also configured to receive a user input and generate a response information based on the user input, the response information indicating whether or not the image generated by the imaging device is accepted by the user. The controller is further configured to update the preferred operational setting using a machine learning algorithm based on the response information.
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公开(公告)号：US12038570B2
公开(公告)日：2024-07-16
申请号：US17369972
申请日：2021-07-08
CPC分类号： G02B21/33 , G02B21/0048 , G02B21/006
摘要： A microscope includes: an optical system including an immersion objective for an immersion medium of a predetermined refractive index; an aperture stop; and a processor for setting an immersion-free imaging mode in which the optical system is operated without immersion medium. The processor controls the aperture stop in the immersion-free imaging mode to set a numerical aperture of the immersion objective to a reduced value which is lower than a nominal value of the numerical aperture, the numerical aperture being equal to the nominal value when the optical system is operated using the immersion medium without reducing the numerical aperture by the aperture stop. The processor controls the optical system in accordance with the reduced value of the numerical aperture in the immersion-free imaging mode to generate at least one image representing the overview image of the sample.
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公开(公告)号：US12019229B2
公开(公告)日：2024-06-25
申请号：US17265531
申请日：2019-07-19
发明人： Florian Fahrbach
IPC分类号： G02B21/08
CPC分类号： G02B21/086
摘要： A illumination arrangement for a microscope for illuminating a sample with a light sheet includes an illumination input configured to feed an illumination beam along an optical axis of the illumination arrangement and an illumination output which faces a sample side and is configured to output the illumination beam to the sample side. A focusing optical system is provided with a set depth of focus. At least one optical modification element is configured to geometrically modify the illumination beam. Different rays of the illumination beam intersect the optical axis within an axis intersection region at the illumination output. The axis intersection region extends over at least the depth of focus of the focusing optical system along the optical axis.
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