公开(公告)号：US5366964A

公开(公告)日：1994-11-22

申请号：US434305

申请日：1989-11-13

申请人： Richard L. Lindstrom ,  Debra Skelnik

发明人： Richard L. Lindstrom ,  Debra Skelnik

IPC分类号： A61K38/18 ,  A61K31/715

CPC分类号： A61K38/28 ,  A01N1/0226 ,  A61K38/1808 ,  Y10S514/912

摘要： A viscoelastic solution including a buffered solution, 0.01-10% chondroitin sulfate, 0.01-10% hydroxypropyl methylcellulose, and 0.01-10% sodium hyaluronate, pH adjusted to 6.0-8.0 at a osmolarity between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimal essential medium (MEM), phosphate buffered saline (PBS), or buffered balanced salt solution. A cell growth factor or cell growth supplement can also be included in the solution.

摘要翻译： 包含缓冲溶液，0.01-10％硫酸软骨素，0.01-10％羟丙基甲基纤维素和0.01-10％透明质酸钠的粘弹性溶液，在200-400mOsmol / L的渗透压下pH调节至6.0-8.0。 缓冲溶液可以是HEPES缓冲的最小必需培养基（MEM），磷酸盐缓冲盐水（PBS）或缓冲平衡盐溶液。 细胞生长因子或细胞生长补充剂也可以包括在溶液中。

公开(公告)号：US5104787A

公开(公告)日：1992-04-14

申请号：US487919

申请日：1990-03-05

申请人： Richard L. Lindstrom ,  Debra Skelnik

发明人： Richard L. Lindstrom ,  Debra Skelnik

IPC分类号： A01N1/02 ,  A61F9/007 ,  A61K9/08

CPC分类号： A01N1/0226

摘要： A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, including human corneal tissues at low temperatures (2.degree. C. to 15.degree. C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing components, antibiotic(s), ATP precursors and nutrient cell supplements.

摘要翻译： 一种用于眼科应用的定义的无血液药物溶液，其含有一种或多种细胞营养补充剂，其在低温（2℃至15℃）下维持并增强眼组织的保存，包括人角膜组织。 该溶液由限定的水性营养物和电解质溶液组成，补充有糖胺聚糖，一种或多种防腐剂，能量源，缓冲系统，抗氧化剂，膜稳定剂 组分，抗生素，ATP前体和营养细胞补充剂。

公开(公告)号：US4886786A

公开(公告)日：1989-12-12

申请号：US151480

申请日：1988-02-02

申请人： Richard L. Lindstrom ,  Debra L. Skelnik

发明人： Richard L. Lindstrom ,  Debra L. Skelnik

IPC分类号： A61K9/00

CPC分类号： A61K9/0048

摘要： An additive for intraocular irrigation solution or surgical solution which provides the anterior chamber and posterior chamber of the eye with protection during surgical procedures that require irrigation. The additive for the solutions is composed of a balanced salt solution containing dextrose supplemented with chondroitin sulfate. Other chemical compositions can supplement the additive.

摘要翻译： 用于眼内灌注溶液或手术溶液的添加剂，其在需要灌洗的外科手术过程中提供眼睛的前房和后房保护。 溶液的添加剂由含有补充硫酸软骨素的葡萄糖的平衡盐溶液组成。 其他化学成分可以补充添加剂。

公开(公告)号：US4781718A

公开(公告)日：1988-11-01

申请号：US106272

申请日：1987-10-09

申请人： Richard L. Lindstrom

发明人： Richard L. Lindstrom

IPC分类号： A61F2/16

CPC分类号： A61F2/16 ,  A61F2002/1681 ,  A61F2002/1686

摘要： Intraocular lens including loop haptic members each affixed at more than one point to a soft skirt of an optic or to a soft optic for torsional rigidity of the loop haptic member and for preventing loop rotation or pull out in an optic. The loop haptic members each include a main loop haptic member, and two branch members proceeding from the main loop haptic member to affix in securement holes in the edge or surface of an optic. The loops' securement end points include conically shaped end like members which engage within the soft portion of the IOL.

摘要翻译： 包括环形触觉部件的眼内透镜，每个眼睛部件各自固定在光学元件的柔软裙部或柔性光学元件上，用于环形触觉部件的扭转刚度并用于防止光圈中的环转动或拉出。 环形触觉构件各自包括主环触觉构件和从主回路触觉构件进行的两个分支构件，以固定在光学元件的边缘或表面中的固定孔中。 环的固定端点包括接合在IOL的软部分内的锥形端部构件。

公开(公告)号：US4619656A

公开(公告)日：1986-10-28

申请号：US569610

申请日：1984-01-10

申请人： Richard L. Lindstrom

发明人： Richard L. Lindstrom

IPC分类号： A61F2/16

CPC分类号： A61F2/16 ,  A61F2/1664 ,  A61F2/161 ,  A61F2002/1681 ,  A61F2002/1683

摘要： Intraocular lens implant including an optic such as a plano-convex lens, a plurality of outwardly extending loops, and at least one key-hole affixed to one of the loops. In one embodiment, a plano-convex posterior chamber lens implant is provided with at least one key-hole loop in one of the two loops for turn-key insertion by locking a turn-key insertion instrument into a key-hole where the key-hole is at one end of one or both of the loops. The key locking into the key-hole provides for turn-key insertion of the loop with stable, secure, fixation, and control of the superior loop providing movement in all directions and all planes. This provides for rotation of the loop to rotate the lens implant posterior to the iris or into the capsular bag during a superior loop insertion technique.

摘要翻译： 包括诸如平凸透镜的光学器件，多个向外延伸的环路以及固定到一个环路的至少一个键孔的眼内透镜植入物。 在一个实施例中，平凸后房透镜植入物在两个环之一中设置有至少一个键孔环，用于将钥匙插入仪器锁定到钥匙孔中， 孔位于一个或两个环的一端。 锁定在钥匙孔中的钥匙提供了环路的交钥匙插入，其具有稳定，牢固，固定和控制上环在所有方向和所有平面上的运动。 这提供了环路的旋转，以在优异的环路插入技术期间将透镜植入物旋转到虹膜后部或者进入囊袋。

公开(公告)号：US5407669A

公开(公告)日：1995-04-18

申请号：US845660

申请日：1992-03-04

申请人： Richard L. Lindstrom ,  Debra Skelnik

发明人： Richard L. Lindstrom ,  Debra Skelnik

IPC分类号： A01N1/02 ,  A61K31/715 ,  A61K38/17 ,  A61K31/74 ,  C12N5/00

CPC分类号： A01N1/0226 ,  A01N1/021 ,  A01N1/0215

摘要： A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, including human corneal tissues at low temperatures (2.degree. C. to 15.degree. C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing components, antibiotic(s), ATP precursors and nutrient cell supplements.

摘要翻译： 一种用于眼科应用的定义的无血液药物溶液，其含有一种或多种细胞营养补充剂，其在低温（2℃至15℃）下维持并增强眼组织的保存，包括人角膜组织。 该溶液由限定的水性营养物和电解质溶液组成，补充有糖胺聚糖，一种或多种防腐剂，能量源，缓冲系统，抗氧化剂，膜稳定剂 组分，抗生素，ATP前体和营养细胞补充剂。

公开(公告)号：US5204325A

公开(公告)日：1993-04-20

申请号：US695332

申请日：1991-05-03

申请人： Richard L. Lindstrom ,  Debra Skelnik

发明人： Richard L. Lindstrom ,  Debra Skelnik

IPC分类号： A61K38/18

CPC分类号： A61K38/28 ,  A61K38/1808

摘要： Viscoelastic solution including a buffered solution, 0.01-8% chondroitin sulfate, 0.1-8% hydroxypropyl methylcellulose, pH adjusted to 6.0-8.0 at a osmolality between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimum essential media (MEM), phosphate buffer saline (PBS), buffered balanced salt solution, or TC199. A cell growth factor or cell growth supplement is included in the solution.

摘要翻译： 包含缓冲溶液的粘弹性溶液，0.01-8％硫酸软骨素，0.1-8％羟丙基甲基纤维素，在200-400mOsmol / L的重量摩尔渗透压浓度下将pH调节至6.0-8.0。 缓冲溶液可以是HEPES缓冲的最小必需培养基（MEM），磷酸盐缓冲盐水（PBS），缓冲平衡盐溶液或TC199。 细胞生长因子或细胞生长补充剂包括在溶液中。

公开(公告)号：US5013714A

公开(公告)日：1991-05-07

申请号：US284533

申请日：1988-12-15

申请人： Richard L. Lindstrom ,  Debra Skelnik

发明人： Richard L. Lindstrom ,  Debra Skelnik

IPC分类号： A61K38/18

CPC分类号： A61K38/28 ,  A01N1/0226 ,  A61K38/1808 ,  Y10S514/912

摘要： Viscoelastic solution including a buffered solution, 0.01-8% chondroitin sulfate, 0.1-8% hydroxypropyl methylcellulose, pH adjusted to 6.0-8.0 at a osmolality between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimum essential media (MEM), phosphate buffer saline (PBS), buffered balanced salt solution, or TC199. A cell growth factor or cell growth supplement is included in the solution.

摘要翻译： 包含缓冲溶液的粘弹性溶液，0.01-8％硫酸软骨素，0.1-8％羟丙基甲基纤维素，在200-400mOsmol / L的重量摩尔渗透压浓度下将pH调节至6.0-8.0。 缓冲溶液可以是HEPES缓冲的最小必需培养基（MEM），磷酸盐缓冲盐水（PBS），缓冲平衡盐溶液或TC199。 细胞生长因子或细胞生长补充剂包括在溶液中。

公开(公告)号：US4711638A

公开(公告)日：1987-12-08

申请号：US861707

申请日：1986-05-12

申请人： Richard L. Lindstrom

发明人： Richard L. Lindstrom

IPC分类号： A61F2/16 ,  A61B17/00

CPC分类号： A61F2/16 ,  A61F2002/1683

摘要： Intraocular lens including a lens optic having two haptic loops secured substantially adjacent to each other near a common point of the lens optic, and extending about the lens optic to a position opposing the common point of securement about the lens optic. The haptic loops can include notches and positioning holes and the optics can include positioning holes. The mirror image haptic loops assume geometrical haptic configurations of circular segments substantially conforming equidistantly about the circumference of the lens, a two straight sided configuration with a connecting outwardly curved circular segment, a two straight sided configuration with a connecting inwardly curved circular segment, two circular segments with a connecting inverted circular segment, or three circular segments with two connecting inverted circular segments. The lens optics can be plano-convex, bi-convex, meniscus or other like optic configurations, including reversed optics. The lenses can be lathe cut or injection molded. The haptic loops can also be angled forward or planar. An insertion slide is included for assisting in inserting a lens into the eye.

摘要翻译： 人造眼镜包括具有两个触觉环的透镜光学镜片，其在透镜光学元件的公共点附近基本上彼此相邻地固定，并且围绕透镜光学器件延伸到与透镜光学器件周围的公共固定点相对的位置。 触觉环可以包括凹口和定位孔，并且光学元件可以包括定位孔。 镜像触觉环呈现基本上等距离绕透镜圆周的圆形段的几何触觉构型，具有连接向外弯曲的圆形段的两个直边构造，具有连接向内弯曲的圆形段的两个直边构造，两个圆形 具有连接倒立圆形段的段，或具有两个连接倒立圆形段的三个圆形段。 透镜光学器件可以是平凸的，双凸的，弯液面或其他类似的光学配置，包括反向光学器件。 镜片可以车削切割或注射成型。 触觉环也可以向前或平面倾斜。 包括插入滑块以帮助将镜头插入眼睛。

公开(公告)号：US5002569A

公开(公告)日：1991-03-26

申请号：US529883

申请日：1990-05-29

申请人： Richard L. Lindstrom

发明人： Richard L. Lindstrom

IPC分类号： A61F2/16

CPC分类号： A61F2/1613

摘要： An intraocular lens denoted as a YAG dimpled lens or dimpled YAG lens, which includes a barrier rim and a YAG spacer area in a posterior surface of the lens. The barrier rim is 2-4 mm in longitudinal length and the YAG spacer is 3-4 mm in longitudinal length across the surface diameter of an optic of the intraocular lens. The lens optic can be either plano-convex or bi-convex. A cutout for the dimpled YAG spacer is provided which is either a convave or a substantially rectangular geometrical configuration in the posterior surface of the lens. The YAG spacer can also include a trough or a groove geometrical configuration, such as in the configurations of a Maltese cross, a circular trough or groove, or a circular trough or groove with a Maltese cross therein. The barrier rim is 33% to 80% of the total surface are of the posterior surface of the lens.

摘要翻译： 一种称为YAG凹凸透镜或凹凸YAG透镜的眼内透镜，其包括镜片后表面中的屏障边缘和YAG间隔区域。 屏障边缘在纵向长度上为2-4mm，并且YAG间隔物在纵向长度上穿过眼内透镜的光学元件的表面直径为3-4mm。 透镜光学元件可以是平凸的或双凸的。 提供了用于凹凸的YAG间隔件的切口，其是在镜片的后表面中的手链或基本上矩形的几何构型。 YAG间隔物还可以包括槽或凹槽几何构型，例如在马耳他十字架，圆形槽或凹槽的构造中，或者在其中具有马耳他十字的圆形槽或槽。 屏障边缘是总表面的33％至80％是透镜的后表面。