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公开(公告)号：US10350184B2
公开(公告)日：2019-07-16
申请号：US15566955
申请日：2016-04-14
申请人： METABRAIN RESEARCH
发明人： Sophie N. Raynal , Micheline R. Kergoat , Valerie Autier , Christine G. Charon , Jean-Denis Durand , Franck F. Lepifre , Annick M. Audet
IPC分类号： A61K31/15 , A61K31/50 , A61P21/00 , A61K31/165 , A61K31/197 , A61K31/216 , A61K31/495 , A61K31/4402 , A61K31/4406
摘要： This invention relates to oxime and alkoxy derivatives of the general formula (I), or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.
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公开(公告)号：US20190247385A1
公开(公告)日：2019-08-15
申请号：US16329281
申请日：2017-09-05
申请人： METABRAIN RESEARCH
发明人： Sophie N. Raynal , Annick Audet , Valérie Autier , Christine Charon , Jean-Denis Durand , Micheline Kergoat
CPC分类号： A61K31/47 , A61K9/0053 , A61P21/00
摘要： The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.
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公开(公告)号：US09777015B2
公开(公告)日：2017-10-03
申请号：US14415988
申请日：2013-07-16
申请人： METABRAIN RESEARCH
发明人： Franck F. Lepifre , Gersande R. Lena , Valerie Autier , Micheline R. Kergoat , Lauren R. Faveriel , Christine G. Charon , Sophie N. Raynal , Annick M. Audet
IPC分类号： A61K31/4025 , C07D493/14 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07H9/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , A61K31/381 , A61K31/4436 , A61K31/5377 , A61K45/06
CPC分类号： C07D493/14 , A61K31/381 , A61K31/4025 , A61K31/4436 , A61K31/5377 , A61K45/06 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07H9/04
摘要： The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug in particular intended for treating and/or preventing diabetes, its complications and/or associated pathologies, advantageously diabetes of type II and hyperglycemia.
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公开(公告)号：US11369595B2
公开(公告)日：2022-06-28
申请号：US16329281
申请日：2017-09-05
申请人： METABRAIN RESEARCH
发明人： Sophie N. Raynal , Annick Audet , Valérie Autier , Christine Charon , Jean-Denis Durand , Micheline Kergoat
摘要： The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.
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公开(公告)号：US09381191B2
公开(公告)日：2016-07-05
申请号：US14415985
申请日：2013-07-16
申请人： METABRAIN RESEARCH
发明人： Franck F. Lepifre , Gersande R. Lena , Valerie Autier , Micheline R. Kergoat , Christine G. Charon , Sophie N. Raynal , Annick M. Audet
IPC分类号： C07D471/02 , A61K31/437 , C07D471/04 , A61K31/155 , A61K31/444 , A61K31/5377
CPC分类号： A61K31/437 , A61K31/155 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention relates to imidazopyridine derivatives of the following general formula I: and to their use as a drug, in particular in treating and/or preventing diabetes, its complications and/or associated pathologies.
摘要翻译： 本发明涉及以下通式I的咪唑并吡啶衍生物及其用作药物，特别是治疗和/或预防糖尿病及其并发症和/或相关病理学的用途。
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