中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

135 records (took 0.07 seconds)

    Methods and systems for determining spatial patterns of biological targets in a sample
    1.
    发明授权
    Methods and systems for determining spatial patterns of biological targets in a sample 有权

    公开(公告)号：US11821024B2

    公开(公告)日：2023-11-21

    申请号：US18129357

    申请日：2023-03-31

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Mark S. Chee ,  David A. Routenberg

    IPC: C12Q1/6809 ,  B01L3/00

    CPC classification number: C12Q1/6809 ,  B01L3/5027

    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
    2.
    发明公开
    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE 审中-公开

    公开(公告)号：US20230304074A1

    公开(公告)日：2023-09-28

    申请号：US18129357

    申请日：2023-03-31

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Mark S. Chee ,  David A. Routenberg

    IPC: C12Q1/6809

    CPC classification number: C12Q1/6809 ,  B01L3/5027

    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

    Peptide constructs and assay systems
    9.
    发明授权
    Peptide constructs and assay systems 有权

    公开(公告)号：US11340232B2

    公开(公告)日：2022-05-24

    申请号：US15967461

    申请日：2018-04-30

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Igor A. Kozlov ,  Mark S. Chee ,  Petr Capek ,  David A. Routenberg

    IPC: G01N33/68 ,  C12N15/10

    Abstract: The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.

    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
    10.
    发明申请
    METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE 有权

    公开(公告)号：US20210317510A1

    公开(公告)日：2021-10-14

    申请号：US17358280

    申请日：2021-06-25

    Applicant: Prognosys Biosciences, Inc.

    Inventor： Mark S. CHEE ,  David A. ROUTENBERG

    IPC: C12Q1/6809

    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

Patent Agency Ranking