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1.发明申请Methods and Devices for Concentration and Purification of Analytes for Chemical Analysis Including Matrix-Assisted Laser Desportion/Ionization (MALDI) Mass Spectrometry (MS) 审中-公开用于化学分析分析物浓缩和纯化的方法和装置，包括基质辅助激光分配/电离（MALDI）质谱（MS）公开(公告)号：US20100133098A1
公开(公告)日：2010-06-03
申请号：US12419126
申请日：2009-04-06
申请人： Dean Hafeman , Kilian Dill , James B. Harkins , Richard M. Caprioli , Jeremy Norris , Nathan S. Lewis , Daniel Kuban , Charles E. Witkowski, II
发明人： Dean Hafeman , Kilian Dill , James B. Harkins , Richard M. Caprioli , Jeremy Norris , Nathan S. Lewis , Daniel Kuban , Charles E. Witkowski, II
IPC分类号： G01N33/487 , G01N27/28
CPC分类号： G01N27/44756 , B01L3/50255 , B01L2300/0829 , B01L2400/0415
摘要： Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
摘要翻译： 公开了分析方法和装置，用于通过电泳驱动分析物通过筛分基质来分离低丰度分析物，以首先去除高分子量物质。 随后，剩余的低丰度分析物电泳聚焦到捕获膜上，其中分析物结合在小的捕获位点内。 在该步骤之后，捕获膜可以被干燥，然后连接到导电的MALDI样品板上。
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2.发明申请Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) 失效用于化学分析的分析物浓缩和纯化的方法和装置，包括基质辅助激光解吸/电离（MALDI）质谱（MS）公开(公告)号：US20050116161A1
公开(公告)日：2005-06-02
申请号：US10963336
申请日：2004-10-12
申请人： Dean Hafeman , Kilian Dill , James Harkins , Richard Caprioli , Jeremy Norris , Nathan Lewis , Daniel Kuban , Charles Witkowski
发明人： Dean Hafeman , Kilian Dill , James Harkins , Richard Caprioli , Jeremy Norris , Nathan Lewis , Daniel Kuban , Charles Witkowski
IPC分类号： B01L3/00 , G01N20060101 , G01N27/447 , H01J49/00
CPC分类号： G01N27/44756 , B01L3/50255 , B01L2300/0829 , B01L2400/0415
摘要： Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
摘要翻译： 公开了分析方法和装置，用于通过电泳驱动分析物通过筛分基质来分离低丰度分析物，以首先去除高分子量物质。 随后，剩余的低丰度分析物电泳聚焦到捕获膜上，其中分析物结合在小的捕获位点内。 在该步骤之后，捕获膜可以被干燥，然后连接到导电的MALDI样品板上。
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3.发明申请Methods and devices for concentration and fractionation of analytes for chemical analysis 审中-公开用于化学分析的分析物的浓缩和分馏方法和装置公开(公告)号：US20070258864A1
公开(公告)日：2007-11-08
申请号：US11636412
申请日：2006-12-08
申请人： Ryan Braymer , Floria Cheng , Eric Claude , Jeffrey Loper , Craig Mauch , Ralph Paul , Ron Wilson
发明人： Ryan Braymer , Floria Cheng , Eric Claude , Jeffrey Loper , Craig Mauch , Ralph Paul , Ron Wilson
CPC分类号： G01N35/00029 , G01N35/00584 , G01N2035/00148 , G01N2035/00306 , H01J49/0418
摘要： A multi-well cassette configuration and an instrument capable of accepting the cassette and thereafter pre-concentrating and purifying analytes from biological samples held in the cassette wells, such as human serum, for subsequent analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS).
摘要翻译： 多孔盒构造和能够接受盒并且此后预先浓缩和净化保存在盒式细胞孔（例如人血清）中的生物样品中的分析物的仪器，以便随后通过基质辅助激光解吸电离质谱法（MALDI 女士）。
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4.发明申请Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis Including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS) 审中-公开用于化学分析的分析物的浓缩分离方法和装置，包括基质辅助激光解吸/电离（MALDI）质谱（MS）公开(公告)号：US20090071834A1
公开(公告)日：2009-03-19
申请号：US12136021
申请日：2008-06-09
申请人： Dean G. Hafeman , James B. Harkins, IV , Jeremy L. Norris , Sheila N. Baker , Donald R. Loveday , Daniel P. Kuban , Richard M. Caprioli , Charles E. Witkowski, II , Benjamin B. Katz , Salvadore J. Pastor
发明人： Dean G. Hafeman , James B. Harkins, IV , Jeremy L. Norris , Sheila N. Baker , Donald R. Loveday , Daniel P. Kuban , Richard M. Caprioli , Charles E. Witkowski, II , Benjamin B. Katz , Salvadore J. Pastor
IPC分类号： G01N27/447
CPC分类号： G01N1/405 , B01L3/50255 , G01N33/6851
摘要： A device is described for pre-concentration and purification of analytes from biological samples (such as human serum, plasma, homogenized solid tissue, etc.) to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.
摘要翻译： 描述了用于通过基质辅助激光解吸电离质谱（MALDI MS）分析的生物样品（例如人血清，血浆，均质化固体组织等）的分析物的预浓缩和纯化的装置和使用方法 提供。
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5.发明申请Methods and devices for concentration and fractionation of analytes for chemical analysis 审中-公开用于化学分析的分析物的浓缩和分馏方法和装置公开(公告)号：US20100292105A1
公开(公告)日：2010-11-18
申请号：US12658870
申请日：2010-02-16
申请人： Ryan Braymer , Floria Cheng , Eric Claude , Jeffrey Cameron Loper , Craig Mauch , Ralph Paul , Ron Wilson
发明人： Ryan Braymer , Floria Cheng , Eric Claude , Jeffrey Cameron Loper , Craig Mauch , Ralph Paul , Ron Wilson
IPC分类号： C40B60/12
CPC分类号： G01N35/00029 , G01N35/00584 , G01N2035/00148 , G01N2035/00306 , H01J49/0418
摘要： A multi-well cassette configuration and an instrument capable of accepting the cassette and thereafter pre-concentrating and purifying analytes from biological samples held in the cassette wells, such as human serum, for subsequent analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS).
摘要翻译： 多孔盒构造和能够接受盒并且此后预先浓缩和净化保存在盒式细胞孔（例如人血清）中的生物样品中的分析物的仪器，以便随后通过基质辅助激光解吸电离质谱法（MALDI 女士）。
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6.发明授权Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization(MALDI) mass spectrometry (MS) 失效用于化学分析的分析物浓缩和纯化的方法和装置，包括基质辅助激光解吸/电离（MALDI）质谱（MS）公开(公告)号：US07534338B2
公开(公告)日：2009-05-19
申请号：US10963336
申请日：2004-10-12
申请人： Dean Hafeman , Kilian Dill , James B. Harkins , Richard M. Caprioli , Jeremy Norris , Nathan S. Lewis , Daniel Kuban , Charles E. Witkowski, II
发明人： Dean Hafeman , Kilian Dill , James B. Harkins , Richard M. Caprioli , Jeremy Norris , Nathan S. Lewis , Daniel Kuban , Charles E. Witkowski, II
IPC分类号： H01J49/04
CPC分类号： G01N27/44756 , B01L3/50255 , B01L2300/0829 , B01L2400/0415
摘要： Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
摘要翻译： 公开了分析方法和装置，用于通过电泳驱动分析物通过筛分基质来分离低丰度分析物，以首先去除高分子量物质。 随后，剩余的低丰度分析物电泳聚焦到捕获膜上，其中分析物结合在小的捕获位点内。 在该步骤之后，捕获膜可以被干燥，然后连接到导电的MALDI样品板上。
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公开(公告)号：US20110220501A1
公开(公告)日：2011-09-15
申请号：US12967890
申请日：2010-12-14
CPC分类号： G01N27/44713
摘要： An electrophoretic notch filter apparatus including a gel cartridge having at least one sample channel, an electrode and a counter electrode each engagable with the sample channel, a user interface for programming one or more steps for a sample channel into a processor to form a programmed sequence and an electrophoretic controller for implementing the programmed sequence.
摘要翻译： 一种电泳陷波滤波器装置，包括具有至少一个采样通道的凝胶盒，每个都可与样品通道相连的电极和对电极，用于将用于样品通道的一个或多个步骤编程到处理器中以形成编程序列的用户界面 以及用于实现编程序列的电泳控制器。
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