公开(公告)号：US12085583B2

公开(公告)日：2024-09-10

申请号：US17319842

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: G01N33/00 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L9/00 ,  B01L9/06 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/543 ,  G01N33/569 ,  G01N33/62 ,  G01N33/68 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N33/50

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/543 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  B01L9/52 ,  B01L2300/1827 ,  B01L2300/1855 ,  G01N2015/012 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N33/5005 ,  G01N35/00 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US11958657B2

公开(公告)日：2024-04-16

申请号：US16499504

申请日：2018-03-28

Applicant: QIAGEN Healthcare Biotechnologies Systems GmbH

Inventor： Kathryn Louise Lamerton ,  Michael John Smith ,  Phillip Evans ,  Kristina Swann

IPC: B65D25/10 ,  B01L9/00 ,  G01N35/00

CPC classification number: B65D25/107 ,  B01L9/52 ,  G01N35/00029 ,  B01L2200/025 ,  B01L2300/0861 ,  G01N2035/00089 ,  G01N2035/00148

Abstract: Disclosed is a lidded magazine (100) for holding plural generally flat sample collection cards (10) in spaced parallel relation, the magazine is open at its top and includes upstanding opposed side walls (110,120), each wall (110,120) further including plural opposed pairs of inwardly extending wall ribs (112,122) spaced along each wall (110,120) to provide therebetween card accepting slots, a first slot dimension (W) being defined by the spacing between an interior face (154) of each wall, the magazine being characterised in that the walls (110,120) at the top (152) of each slot (150) are tapered outwardly such that the first dimension (W) is greatest at the top of the slot (150).

公开(公告)号：US11946926B2

公开(公告)日：2024-04-02

申请号：US16955014

申请日：2018-12-18

Applicant: BIO-RAD EUROPE GMBH

Inventor： Emmanuel Guignet ,  Stephane Bombard

IPC: G01N33/49 ,  B01L9/06 ,  G01N1/38 ,  G01N15/04 ,  G01N15/05 ,  G01N35/00

CPC classification number: G01N33/491 ,  B01L9/06 ,  G01N1/38 ,  G01N15/042 ,  G01N15/05 ,  G01N35/00029 ,  B01L2200/025 ,  B01L2300/0627 ,  G01N2015/047 ,  G01N2035/00148 ,  G01N2035/00495

Abstract: A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.

公开(公告)号：US11828766B2

公开(公告)日：2023-11-28

申请号：US16226164

申请日：2018-12-19

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Aleksandar Vacic ,  Nathan Purmort ,  Eric Stern ,  Anna Passernig ,  Paul Otten ,  Randy Tragni ,  Ronan Hayes ,  Andriy Tsupryk ,  Bruce Richardson

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/10 ,  B01J20/04 ,  C12Q1/18 ,  G01N21/01 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12M1/34 ,  G01N35/04 ,  G01N15/02

CPC classification number: G01N15/02 ,  B01J20/041 ,  C12Q1/18 ,  G01N21/01 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/028 ,  G01N35/1065 ,  C12M33/10 ,  C12M41/36 ,  C12M41/48 ,  C12M47/02 ,  G01N2021/0112 ,  G01N2035/00039 ,  G01N2035/00118 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00465 ,  G01N2035/00485 ,  G01N2035/00524 ,  G01N2035/00841 ,  G01N2035/0425

Abstract: In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.

公开(公告)号：US11795503B2

公开(公告)日：2023-10-24

申请号：US16512276

申请日：2019-07-15

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： George A. Fry ,  Christina E. Inman ,  John Bridgham ,  Timothy Hunkapiller ,  Charles S. Vann

IPC: C12Q1/6869 ,  G01N35/10 ,  B01L3/00 ,  G01N35/00 ,  G01N21/11 ,  B01F33/30 ,  B01F33/40 ,  B01J19/00 ,  C12Q1/6874 ,  G02B21/34 ,  G01N21/05

CPC classification number: C12Q1/6869 ,  B01F33/30 ,  B01F33/403 ,  B01J19/0046 ,  B01L3/50273 ,  B01L3/502715 ,  C12Q1/6874 ,  G01N21/11 ,  G01N35/00069 ,  G01N35/0099 ,  G01N35/1002 ,  B01J19/0093 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00466 ,  B01J2219/00511 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00869 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2400/0427 ,  G01N21/05 ,  G01N35/1011 ,  G01N35/1097 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/1034 ,  G02B21/34 ,  Y10T436/11 ,  Y10T436/143333

Abstract: According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.

公开(公告)号：US20190005304A1

公开(公告)日：2019-01-03

申请号：US16102118

申请日：2018-08-13

Applicant: Massachusetts Institute of Technology

Inventor： Viktor A. Adalsteinsson ,  Denis Loginov ,  J. Christopher Love ,  Alan Stockdale ,  Todd Gierahn

IPC: G06K9/00 ,  G01N33/483 ,  G01N15/14 ,  G01N35/00

CPC classification number: G06K9/00147 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0896 ,  B01L2300/12 ,  G01N15/1425 ,  G01N15/1463 ,  G01N33/4833 ,  G01N35/00029 ,  G01N35/00871 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2035/00148 ,  G02B21/16 ,  G02B21/26 ,  G06K9/0014 ,  G06K9/036 ,  G06K9/4647 ,  G06K9/4652 ,  G06K9/4661 ,  H04N5/2256

Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.

公开(公告)号：US20180230510A1

公开(公告)日：2018-08-16

申请号：US15714457

申请日：2017-09-25

Applicant: True Health IP LLC

Inventor： Ross Higgins

IPC: C12Q1/6806 ,  C12N15/10

CPC classification number: C12Q1/6806 ,  C12N15/1013 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N35/00029 ,  G01N35/00732 ,  G01N2035/00148 ,  G01N2035/00752 ,  G01N2035/00831 ,  C12Q2527/101 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: A method for analyzing genomic DNA includes introducing a plurality of samples comprising human cells into individual vessels in each of a plurality of multi-vessel well plates. At least a subset of the human cells in the plurality of samples is lysed without the use of heat. DNA in the at least a subset of lysed human cells is isolated with the use of a plurality of paramagnetic beads. The isolated DNA is analyzed to identify one or more single nucleotide polymorphisms (SNPs), wherein the lysing, isolating, and analyzing steps are performed substantially in parallel for each of the plurality of samples.

公开(公告)号：US10018643B2

公开(公告)日：2018-07-10

申请号：US14848775

申请日：2015-09-09

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Chinmay Pangarkar ,  Samartha Anekal ,  John K. Frankovich ,  Michael Chen ,  Timothy Smith

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  B01L9/00 ,  G01N15/14 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20180128818A1

公开(公告)日：2018-05-10

申请号：US15574852

申请日：2016-05-18

Applicant: BIO-RAD INNOVATIONS ,  DIAMED GMBH

Inventor： JULIEN AGUSTI ,  STEPHANE BOMBARD ,  FREDERIC BUFFIERE

IPC: G01N33/53 ,  G01N33/538 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00 ,  B01L3/00

CPC classification number: G01N33/5304 ,  B01L3/502 ,  B01L3/50215 ,  B01L2200/142 ,  B01L2300/0832 ,  G01N33/5306 ,  G01N33/538 ,  G01N33/54366 ,  G01N33/80 ,  G01N35/00069 ,  G01N2035/00148

Abstract: The present disclosure relates to a device for detecting an analyte in a sample, and especially for detecting antigen/antibody reactions, wherein said device comprises a layer composed of a low-density immiscible compound. The disclosure also relates to a method for detecting an analyte in a sample and especially for detecting antigen/antibody reactions in a device comprising a layer composed of a low-density immiscible compound. The disclosure further relates to the uses of such low-density immiscible compound.

公开(公告)号：US09952240B2

公开(公告)日：2018-04-24

申请号：US14872995

申请日：2015-10-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.