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公开(公告)号：US20240277766A1
公开(公告)日：2024-08-22
申请号：US18541684
申请日：2023-12-15
发明人： Marcela GUZMAN AYALA , Russell Morrison GORDLEY , Michelle Elizabeth HUNG , Gary LEE , Timothy Kuan-Ta LU
CPC分类号： A61K35/17 , A61K9/0019 , A61K39/4613 , A61K39/4631 , A61K39/464402 , A61P35/00 , C07K14/5434 , C07K14/5443 , C07K16/303 , C12N5/0646 , A61K2239/13 , A61K2239/21 , C07K2317/622 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C12N2510/00
摘要： Described herein are immunoresponsive cells engineered to express cytokines, chimeric receptors, and synthetic transcription factor systems. Also described herein are nucleic acids, cells, and methods directed to the same.
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公开(公告)号：US20240277765A1
公开(公告)日：2024-08-22
申请号：US18501925
申请日：2023-11-03
发明人： Brian Scott Garrison , Jennifer Chien , Kathryn Armstrong Loving , Russell Morrison Gordley , Michelle Elizabeth Hung
IPC分类号： A61K35/17 , A61K38/00 , C07K14/725 , C07K16/28
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2803 , C07K16/2863 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2319/03
摘要： Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
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公开(公告)号：US20240226296A9
公开(公告)日：2024-07-11
申请号：US18377191
申请日：2023-10-05
发明人： Michelle Elizabeth Hung , Rebecca Tayler Cottman , Russell Morrison Gordley , Gary Lee , Timothy Kuan-Ta Lu , Srinivasaraghavan Kannan , Chandra Shekhar Verma
IPC分类号： A61K39/00
CPC分类号： A61K39/4635 , A61K39/4613 , A61K39/463
摘要： Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
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公开(公告)号：US20240082303A1
公开(公告)日：2024-03-14
申请号：US18143338
申请日：2023-05-04
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4613 , A61K39/4631 , A61K39/46444 , C07K14/5434 , C07K14/5443 , A61K2239/21 , A61K2239/22 , C07K2319/50
摘要： Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.
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公开(公告)号：US20210189367A1
公开(公告)日：2021-06-24
申请号：US16771510
申请日：2018-12-11
IPC分类号： C12N9/50 , C07K14/705 , C12N5/0783 , A61K35/17 , C07K16/32 , C07K16/28
摘要： The present disclosure provides inducible cell receptors and therapeutic cells comprising the inducible cell receptors. Further provided are methods of preparing the therapeutic cells and methods of treating a subject by administering the therapeutic cells and regulating activity of (e.g. activating and/or inactivating) the cell receptors.
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公开(公告)号：US12005081B2
公开(公告)日：2024-06-11
申请号：US17338528
申请日：2021-06-03
发明人： Brian Scott Garrison , Jennifer Chien , Kathryn Armstrong Loving , Russell Morrison Gordley , Michelle Elizabeth Hung
IPC分类号： A61K35/17 , A61K39/00 , C07K14/725 , C07K16/28 , C07K16/30 , C07K16/40 , C07K16/46 , A61K38/00
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2803 , C07K16/2863 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2319/03
摘要： Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
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公开(公告)号：US20240173410A1
公开(公告)日：2024-05-30
申请号：US18504037
申请日：2023-11-07
IPC分类号： A61K39/00 , C07K14/725 , C07K16/28
CPC分类号： A61K39/464411 , A61K39/4613 , A61K39/4631 , C07K14/7051 , C07K16/2803 , C07K2317/622 , C07K2319/03
摘要： Provided herein are chimeric proteins comprising an antigen-binding domain specific for V-Set And Immunoglobulin Domain Containing 2 (VSIG2). Also provided herein are cells, polynucleotides, vectors, compositions, and methods directed to chimeric proteins comprising an antigen-binding domain specific for VSIG2.
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公开(公告)号：US20240141364A1
公开(公告)日：2024-05-02
申请号：US18482513
申请日：2023-10-06
CPC分类号： C12N15/635 , A61K31/45 , A61K35/12 , A61K47/64 , C07K14/4703 , C07K2319/81
摘要： Provided herein are chimeric polypeptides for drug-regulated transcriptional repression. Also provided are methods of inhibiting repression of a gene of interest.
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公开(公告)号：US20240131159A1
公开(公告)日：2024-04-25
申请号：US18377191
申请日：2023-10-04
发明人： Michelle Elizabeth Hung , Rebecca Tayler Cottman , Russell Morrison Gordley , Gary Lee , Timothy Kuan-Ta Lu , Srinivasaraghavan Kannan , Chandra Shekhar Verma
IPC分类号： A61K39/00
CPC分类号： A61K39/4635 , A61K39/4613 , A61K39/463
摘要： Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
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公开(公告)号：US20220378842A1
公开(公告)日：2022-12-01
申请号：US17848320
申请日：2022-06-23
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , A61P35/00 , C07K14/715 , C12N5/0775 , C12N15/63
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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