公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US20200147057A1

公开(公告)日：2020-05-14

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin XIE ,  Dezhu ZHANG ,  Shunjun DING ,  Chengyuan LIANG

发明人： Xiaolin XIE ,  Dezhu ZHANG ,  Shunjun DING ,  Chengyuan LIANG

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

IPC分类号： C07C271/02 ,  C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

公开(公告)号：US20200376056A1

公开(公告)日：2020-12-03

申请号：US16993599

申请日：2020-08-14

申请人： Xiaolin XIE ,  Dezhu ZHANG ,  Jianguo MENG ,  Yu WANG ,  Xuhua ZHOU ,  Zhong MENG ,  Nan HUI ,  Juan LI

发明人： Xiaolin XIE ,  Dezhu ZHANG ,  Jianguo MENG ,  Yu WANG ,  Xuhua ZHOU ,  Zhong MENG ,  Nan HUI ,  Juan LI

IPC分类号： A61K36/16 ,  B01D11/02 ,  B01D21/26

摘要： A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.