公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

IPC分类号： C07C271/02 ,  C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10336689B1

公开(公告)日：2019-07-02

申请号：US16359963

申请日：2019-03-20

申请人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

发明人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

IPC分类号： C07C251/24 ,  A61P35/00 ,  C07C249/02

摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

发明人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

IPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

CPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

公开(公告)号：US10023765B2

公开(公告)日：2018-07-17

申请号：US15605985

申请日：2017-05-26

申请人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

发明人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

IPC分类号： C09H3/02 ,  B05D3/00 ,  B05D1/18 ,  B65D65/46

摘要： A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.

公开(公告)号：US10100036B2

公开(公告)日：2018-10-16

申请号：US15713934

申请日：2017-09-25

申请人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D401/12

摘要： A lappaconitine aza-cinnamic acid derivative having the following formula (I): X is C or N, and R1, R2, and R3 are independently H or lower alkyl. A method of preparing the lappaconitine aza-cinnamic acid derivative of formula (I) is also disclosed.

公开(公告)号：US10072020B1

公开(公告)日：2018-09-11

申请号：US15957867

申请日：2018-04-19

申请人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D491/107

CPC分类号： C07D491/107

摘要： An isatin spiro compound having the following formula (I): R1 is halogen or C1-3 alkyl; R2 is C1-3 alkyl or benzyl; and R3 and R3′ are independently H, C1-3 alkyl or phenyl.