公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

发明人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10336689B1

公开(公告)日：2019-07-02

申请号：US16359963

申请日：2019-03-20

申请人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

发明人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

IPC分类号： C07C251/24 ,  A61P35/00 ,  C07C249/02

摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

IPC分类号： C07C271/02 ,  C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

IPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

CPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

公开(公告)号：US09758503B1

公开(公告)日：2017-09-12

申请号：US15489711

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xuechuan Wang ,  Xiaolin Xie ,  Dezhu Zhang

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A compound with antitumor activities is represented by formula A or formula B R1, R2, R3, and R4 are independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.

公开(公告)号：US11219652B2

公开(公告)日：2022-01-11

申请号：US16993599

申请日：2020-08-14

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Jianguo Meng ,  Yu Wang ,  Xuhua Zhou ,  Zhong Meng ,  Nan Hui ,  Juan Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Jianguo Meng ,  Yu Wang ,  Xuhua Zhou ,  Zhong Meng ,  Nan Hui ,  Juan Li

IPC分类号： A61K36/16 ,  B01D11/02 ,  B01D37/00 ,  B01D21/26

摘要： A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.

公开(公告)号：US20140193748A1

公开(公告)日：2014-07-10

申请号：US14131676

申请日：2012-05-25

申请人： Xiaolin Xie ,  Haiyan Peng ,  Xingping Zhou ,  Chengfu Zheng ,  Hongwei Ge

发明人： Xiaolin Xie ,  Haiyan Peng ,  Xingping Zhou ,  Chengfu Zheng ,  Hongwei Ge

IPC分类号： G03H1/04

CPC分类号： G03H1/04 ,  C08F2/50 ,  G03F7/001 ,  G03F7/029 ,  G03F7/031 ,  G03H1/181 ,  G03H2260/12 ,  G11B7/24044 ,  G11B7/245

摘要： The present invention provides a visible light photoinitiating system for preparing a holographic photopolymer material with high-diffraction efficiency. The photoinitiating system comprises a photosensitizer and a co-initiator, and its mechanism is that the photosensitizer transforms from ground state to excited state after absorbing photons, and then interacts with the co-initiator through transfer of electrons and protons, which produces an alkyl (or aryl) free radical R and a ketyl radical K; wherein the free radical R initiates the addition polymerization of monomers that are capable of free radical polymerization, whereas the radical K inhibits the chain propagation of the macromolecular free radicals to a certain degree due to the steric hindrance effect, and thus delays the gelation time of the photopolymerization, which helps to increase the phase separation between the polymer and the functional components. A holographic photopolymer material with high-diffraction efficiency can be obtained by employing this visible light photoinitiating system.

摘要翻译： 本发明提供了一种制备具有高衍射效率的全息光聚合物材料的可见光光引发体系。 光引发剂体系包括光敏剂和共引发剂，其机理是光敏剂在吸收光子后从基态转化为激发态，然后通过电子和质子的转移与共引发剂相互作用，产生烷基（ 或芳基）自由基R和酮基K; 其中自由基R引发能够进行自由基聚合的单体的加成聚合，而基团K由于空间位阻效应而在一定程度上抑制大分子自由基的链增长，因此延迟了胶束化时间 该光聚合有助于增加聚合物和功能组分之间的相分离。 可以通过使用该可见光光引发体系获得具有高衍射效率的全息光敏聚合物材料。

公开(公告)号：US09753431B2

公开(公告)日：2017-09-05

申请号：US14131676

申请日：2012-05-25

申请人： Xiaolin Xie ,  Haiyan Peng ,  Xingping Zhou ,  Chengfu Zheng ,  Hongwei Ge

发明人： Xiaolin Xie ,  Haiyan Peng ,  Xingping Zhou ,  Chengfu Zheng ,  Hongwei Ge

IPC分类号： C08F2/52 ,  C08F2/42 ,  G03H1/04 ,  C08F2/50 ,  G03F7/00 ,  G03F7/029 ,  G03F7/031 ,  G11B7/24044 ,  G11B7/245 ,  G03H1/18

CPC分类号： G03H1/04 ,  C08F2/50 ,  G03F7/001 ,  G03F7/029 ,  G03F7/031 ,  G03H1/181 ,  G03H2260/12 ,  G11B7/24044 ,  G11B7/245

摘要： The present invention provides a visible light photoinitiating system for preparing a holographic photopolymer material with high-diffraction efficiency. The photoinitiating system comprises a photosensitizer and a co-initiator, and its mechanism is that the photosensitizer transforms from ground state to excited state after absorbing photons, and then interacts with the co-initiator through transfer of electrons and protons, which produces an alkyl (or aryl) free radical R and a ketyl radical K; wherein the free radical R initiates the addition polymerization of monomers that are capable of free radical polymerization, whereas the radical K inhibits the chain propagation of the macromolecular free radicals to a certain degree due to the steric hindrance effect, and thus delays the gelation time of the photopolymerization, which helps to increase the phase separation between the polymer and the functional components. A holographic photopolymer material with high-diffraction efficiency can be obtained by employing this visible light photoinitiating system.