公开(公告)号：US07593230B2

公开(公告)日：2009-09-22

申请号：US11182309

申请日：2005-07-14

Applicant: Roxanne E. Abul-Haj ,  N. Alan Abul-Haj ,  Timothy W. Stippick ,  Kevin H. Hazen

Inventor： Roxanne E. Abul-Haj ,  N. Alan Abul-Haj ,  Timothy W. Stippick ,  Kevin H. Hazen

IPC: H05K7/20

CPC classification number: H01L23/467 ,  F28F3/02 ,  F28F13/08 ,  H01L23/3737 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The invention relates to a heatsink. More particularly, the invention relates to a heatsink having tapered geometry that improves passive cooling efficiency. A tapered geometry between heatsink heat dissipation elements, as a function of distance along a z-axis opposing gravity, decreases resistance to rarification of passively flowing cooling gas upon heating. Thus, the tapered heatsink elements result in higher velocity of gas flow and increased cooling efficiency of the heatsink. Optionally, the heatsink is made from a thermally conductive polymer allowing the heatsink to be created in complex shapes using injection molding.

Abstract translation: 本发明涉及一种散热器。 更具体地说，本发明涉及具有提高被动冷却效率的锥形几何形状的散热器。 散热器散热元件之间的锥形几何形状作为与z轴相对重力的距离的函数，降低了被加热时对被动流动的冷却气体进行扩展的阻力。 因此，锥形散热元件导致较高的气流速度和散热器的冷却效率。 任选地，散热器由导热聚合物制成，允许使用注塑成型形成复杂形状的散热器。

公开(公告)号：US07505801B2

公开(公告)日：2009-03-17

申请号：US11848139

申请日：2007-08-30

Applicant: Stephen L. Monfre ,  George M. Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

Inventor： Stephen L. Monfre ,  George M. Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

IPC: A61B5/1455

CPC classification number: A61B5/6841 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/474

Abstract: A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.

Abstract translation: 公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。 水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。 引导装置还可以包括自动化或半自动化耦合流体输送系统。 使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。

公开(公告)号：US07383069B2

公开(公告)日：2008-06-03

申请号：US10849422

申请日：2004-05-18

Applicant: Timothy L. Ruchti ,  Kevin H. Hazen ,  Thomas B. Blank

Inventor： Timothy L. Ruchti ,  Kevin H. Hazen ,  Thomas B. Blank

IPC: A61B5/1455

CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/359

Abstract: A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.

Abstract translation: 提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。 更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。 在另一个实施例中，引导件用于相对于皮肤组织取样部位显着减少样本探针放置的变化，从而产生使用参考分析物浓度来维持校准性能的能力，有或没有使用参考 频谱在时间附近收集。

公开(公告)号：US07333843B2

公开(公告)日：2008-02-19

申请号：US10824459

申请日：2004-04-13

Applicant: Stephen L. Monfre ,  George Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

Inventor： Stephen L. Monfre ,  George Acosta ,  Thomas B. Blank ,  Kevin H. Hazen

IPC: A61B5/00

CPC classification number: A61B5/6841 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/474

Abstract: A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.

Abstract translation: 公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。 水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。 引导装置还可以包括自动化或半自动化耦合流体输送系统。 使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。

公开(公告)号：US06876931B2

公开(公告)日：2005-04-05

申请号：US10211142

申请日：2002-08-02

Applicant: Alexander D. Lorenz ,  Timothy L. Ruchti ,  Thomas B. Blank

Inventor： Alexander D. Lorenz ,  Timothy L. Ruchti ,  Thomas B. Blank

IPC: A61B5/00 ,  G01N21/27 ,  G01N21/35 ,  G01N31/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359

Abstract: A process for enhancing a multivariate calibration through optimization of a calibration data set operates on a large calibration set of samples that includes measurements and associated reference values to automatically select an optimal sub-set of samples that enables calculation of an optimized calibration model. The process is automatic and bases sample selection on two basic criteria: enhancement of correlation between a partner variable extracted from the independent variable and the dependent variable and reduction of correlation between the dependent variable and interference. The method includes two fundamental steps: evaluation, assigning a measurement of calibration suitability to a subset of data; and optimization, selecting an optimal subset of data as directed by the measurement of suitability. The process is particularly applied in enhancing and automating the calibration process for non-invasive measurement glucose measurement but can be applied in any system involving the calculation of multivariate models from empirical data sets.

Abstract translation: 通过优化校准数据集来增强多变量校准的过程在包括测量和相关参考值的大型校准样本集上进行操作，以自动选择能够计算优化校准模型的最佳样本子集。 该过程是自动的，并且基于两个基本标准的基础样本选择：增强从独立变量提取的伴随变量与因变量之间的相关性，并降低因变量与干扰之间的相关性。 该方法包括两个基本步骤：评估，将校准适用性的度量分配给数据子集; 和优化，根据适合性的测量指导选择最佳的数据子集。 该过程特别应用于增强和自动化非侵入性测量葡萄糖测量的校准过程，但可以应用于涉及从经验数据集计算多变量模型的任何系统中。

公开(公告)号：US07698105B2

公开(公告)日：2010-04-13

申请号：US11168941

申请日：2005-06-27

Applicant: Timothy L. Ruchti ,  Linda Hockersmith ,  Stephen L. Monfre ,  Kevin H. Hazen

Inventor： Timothy L. Ruchti ,  Linda Hockersmith ,  Stephen L. Monfre ,  Kevin H. Hazen

IPC: G06F11/00 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  G01N21/359

Abstract: The invention relates to noninvasive analyte property determination. More particularly, the invention relates to a method and apparatus for performing conditional additional acquisition of noninvasive spectra to improve analyzer performance. Conditional additional data acquisition is used to confirm, update, and/or supplement spectral data.

Abstract translation: 本发明涉及非侵入性分析物质的测定。 更具体地，本发明涉及用于执行非侵入性光谱的条件附加获取以提高分析仪性能的方法和装置。 条件附加数据采集用于确认，更新和/或补充光谱数据。

公开(公告)号：US07640140B2

公开(公告)日：2009-12-29

申请号：US11095331

申请日：2005-03-30

Applicant: Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz

Inventor： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz

IPC: G06F19/00 ,  A61B5/00

CPC classification number: A61B5/14532

Abstract: This invention provides a method and apparatus that corrects for tissue related interference calibration and/or measurement of biological parameters noninvasively. The invention concerns such terms as outlier identification, filtering, spectral correction, and baseline subtraction steps that, when used together, provides for noninvasive measurement of biological parameters, such as glucose concentration.

Abstract translation: 本发明提供一种非侵入性校正组织相关干扰校准和/或生物参数测量的方法和装置。 本发明涉及诸如异常值识别，过滤，光谱校正和基线减法步骤之类的术语，当它们一起使用时，提供诸如葡萄糖浓度的生物学参数的非侵入性测量。

公开(公告)号：US07440786B2

公开(公告)日：2008-10-21

申请号：US11012428

申请日：2004-12-14

Applicant: Linda J. Hockersmith ,  Kevin H. Hazen ,  Timothy L. Ruchti

Inventor： Linda J. Hockersmith ,  Kevin H. Hazen ,  Timothy L. Ruchti

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/7415 ,  A61B5/743 ,  A61B5/7475 ,  A61B5/749 ,  A61B2560/0456 ,  G06F19/00 ,  G16H15/00

Abstract: The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.

Abstract translation: 本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。 更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。 将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。 或者，葡萄糖浓度通过语音合成器或耳塞输出。 这些信息介绍对于医疗专业人员和最终用户都是有用的。 信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

公开(公告)号：US07183102B2

公开(公告)日：2007-02-27

申请号：US11122669

申请日：2005-05-04

Applicant: Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

Inventor： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

IPC: C12M1/34

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359 ,  G01N21/49

Abstract: A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variations that are built into the calibration model. An additional embodiment uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The invention provides a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.

Abstract translation: 一种用于校准无创或可植入的葡萄糖分析仪的方法和装置，其使用替代的侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。 在校准中使用替代入侵或非侵入性葡萄糖测定可以最大限度地减少由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。 另外的实施方案使用非侵入性和替代性侵入性葡萄糖测定与传统的侵入性葡萄糖测定之间的统计学相关性来调整对于传统侵入性葡萄糖浓度的非侵入性或替代性侵入性葡萄糖浓度。 本发明提供了一种用于基于反映观察到的基质的葡萄糖测定和由分析仪更仔细测量的变量进行校准的方法。 葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

公开(公告)号：USD529616S1

公开(公告)日：2006-10-03

申请号：US29217657

申请日：2004-11-19

Applicant: John A. Deros ,  James Ryan Henderson

Designer： John A. Deros ,  James Ryan Henderson