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    Apparatus using reference measurement for calibration
    1.
    发明授权
    Apparatus using reference measurement for calibration 失效
    使用参考测量仪进行校准

    公开(公告)号：US07183102B2

    公开(公告)日：2007-02-27

    申请号：US11122669

    申请日：2005-05-04

    申请人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    发明人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    IPC分类号： C12M1/34

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359 ,  G01N21/49

    摘要： A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variations that are built into the calibration model. An additional embodiment uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The invention provides a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.

    摘要翻译： 一种用于校准无创或可植入的葡萄糖分析仪的方法和装置，其使用替代的侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。 在校准中使用替代入侵或非侵入性葡萄糖测定可以最大限度地减少由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。 另外的实施方案使用非侵入性和替代性侵入性葡萄糖测定与传统的侵入性葡萄糖测定之间的统计学相关性来调整对于传统侵入性葡萄糖浓度的非侵入性或替代性侵入性葡萄糖浓度。 本发明提供了一种用于基于反映观察到的基质的葡萄糖测定和由分析仪更仔细测量的变量进行校准的方法。 葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

    Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
    2.
    发明授权
    Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers 失效
    使用替代部位葡萄糖测定来校准和维护无创和可植入分析仪的方法和设备

    公开(公告)号：US06998247B2

    公开(公告)日：2006-02-14

    申请号：US10377916

    申请日：2003-02-28

    申请人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    发明人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    IPC分类号： C12Q1/54

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359 ,  G01N21/49

    摘要： Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variation that are built into the calibration model. An additional method uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The methods provide a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.

    摘要翻译： 用于校准无创或可植入葡萄糖分析仪的方法利用替代侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。 在校准中使用替代入侵或无创葡萄糖测定可以最小化由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。 一种额外的方法使用非侵入性和替代性侵入性葡萄糖测定与传统侵入性葡萄糖测定之间的统计学相关性来调整传统侵入性葡萄糖浓度的无创或替代侵入性葡萄糖浓度。 这些方法提供了一种基于反映观察到的基质的葡萄糖测定和由分析仪更接近测量的变量进行校准的方法。 葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

    Indirect measurement of tissue analytes through tissue properties
    8.
    发明授权
    Indirect measurement of tissue analytes through tissue properties 失效
    通过组织特性间接测量组织分析物

    公开(公告)号：US07039446B2

    公开(公告)日：2006-05-02

    申请号：US10349573

    申请日：2003-01-22

    申请人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    发明人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/274 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/65 ,  G01N2021/3595

    摘要： Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.

    摘要翻译： 非侵入性测定组织分析物的方法和系统利用分析信号的关键特征反映的组织性质来提高测量精度和精度。 生理条件如组织间隔水分配变化导致测量的皮肤分析信号的复杂变化，导致偏向的非侵入性分析物测量。 通过识别响应于生理变化的分析信号中的关键特征来检测组织性质的变化。 检测到不利于非侵入性测量的条件。 由组织中生理变化偏向的无创测量得到补偿。 在替代实施方案中，基于组织对分析物浓度变化的天然生理反应间接测量分析物。 提供能够进行这种测量的系统。

    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM
    10.
    发明申请
    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
    葡萄糖代谢障碍筛查方法

    公开(公告)号：US20090098587A1

    公开(公告)日：2009-04-16

    申请号：US12099740

    申请日：2008-04-08

    申请人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    发明人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    IPC分类号： C12Q1/54

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/7264 ,  G01N33/66 ,  G01N2800/042 ,  G16H50/20 ,  G16H50/70

    摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.

    摘要翻译： 筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。 数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。 构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。 该方法在被编程为执行该方法的步骤的处理装置上执行。 根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。