公开(公告)号：US09623129B2

公开(公告)日：2017-04-18

申请号：US11534847

申请日：2006-09-25

申请人： Gilbert R. Gonzales ,  Dale DeVore ,  Suresh Srivastava

发明人： Gilbert R. Gonzales ,  Dale DeVore ,  Suresh Srivastava

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/10

CPC分类号： A61K51/1018 ,  A61K51/1093 ,  A61K2121/00

摘要： Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.

公开(公告)号：US09283290B2

公开(公告)日：2016-03-15

申请号：US14229082

申请日：2014-03-28

申请人： SnIP Holdings, Inc.

发明人： Gilbert R. Gonzales ,  Nicholas Chronos

IPC分类号： A61N5/00 ,  A61K51/08 ,  A61K51/10 ,  A61K51/12 ,  C07K16/28

CPC分类号： A61K51/087 ,  A61K51/1027 ,  A61K51/1282 ,  C07K16/28

摘要： Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.

摘要翻译： 用于治疗和成像患者易损斑块和其他炎症区域的组合物，制品和方法依赖于将转换电子发射源（CEES）递送到身体位置。 CEES可以通过偶联到优先结合易损斑块或其它炎性标记的物质来递送。 或者，CEES可以在导管，支架或其他装置上递送。

公开(公告)号：US08834338B2

公开(公告)日：2014-09-16

申请号：US11758937

申请日：2007-06-06

申请人： Suresh Srivastava ,  Gilbert R. Gonzales ,  Roger W. Howell ,  Wesley E. Bolch ,  Radoslav Adzic

发明人： Suresh Srivastava ,  Gilbert R. Gonzales ,  Roger W. Howell ,  Wesley E. Bolch ,  Radoslav Adzic

IPC分类号： A61N5/00 ,  A61F2/91 ,  A61N5/10

CPC分类号： A61N5/1002 ,  A61F2/91 ,  A61F2210/0095 ,  A61F2230/0054 ,  A61N5/1014 ,  A61N2005/1003 ,  A61N2005/1005 ,  A61N2005/1019

摘要： The present invention discloses a method of selectively providing radiation dosimetry to a subject in need of such treatment. The radiation is applied by an implant comprising a body member and 117mSn electroplated at selected locations of the body member, emitting conversion electrons absorbed immediately adjacent selected locations while not affecting surrounding tissue outside of the immediately adjacent area.

摘要翻译： 本发明公开了一种选择性地向需要这种治疗的受试者提供放射剂量测定法的方法。 通过植入物施加放射线，所述植入物包括主体部件和在主体部件的选定位置处电镀的117mSn，在不影响紧邻区域外部的周围组织的情况下发射直接在所选位置附近吸收的转换电子。