公开(公告)号：US20240091557A1

公开(公告)日：2024-03-21

申请号：US18262536

申请日：2022-01-21

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Marc Morcos ,  Akila Viswanathan

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61N5/1016 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1005 ,  A61N2005/1094

摘要： A design, quality assurance, and clinical use procedures are provided for real-time tracking of a custom MRI/CT-compatible brachytherapy applicators. A real-time tracking system is used for applicator implantation, repositioning and tracking during treatment delivery.

公开(公告)号：US10028646B2

公开(公告)日：2018-07-24

申请号：US15897062

申请日：2018-02-14

申请人： West View Research, LLC

发明人： Robert F. Gazdzinski

IPC分类号： A61B1/04 ,  A61B8/00 ,  A61B5/00 ,  A61B5/07 ,  A61B1/31 ,  A61B1/273 ,  A61B1/06 ,  A61B1/00 ,  G06T7/20 ,  A61B8/12 ,  H04L1/00 ,  A61N5/10 ,  A61N2/00 ,  A61B18/20 ,  A61B10/02

CPC分类号： A61B1/041 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00032 ,  A61B1/00036 ,  A61B1/00041 ,  A61B1/0005 ,  A61B1/00059 ,  A61B1/00156 ,  A61B1/00158 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/273 ,  A61B1/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/073 ,  A61B5/411 ,  A61B5/4255 ,  A61B5/6861 ,  A61B5/7232 ,  A61B5/7282 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/56 ,  A61B10/02 ,  A61B18/20 ,  A61B2562/162 ,  A61N2/002 ,  A61N5/1014 ,  A61N2005/1005 ,  G06F19/00 ,  G06T7/20 ,  G06T2207/30028 ,  H04L1/004

摘要： Computerized information acquisition and processing apparatus for use in endoscopic analysis. In one embodiment, the apparatus includes a swallowable apparatus having a digital processor apparatus and video apparatus with image capture and digitization capability, and a wireless interface for accomplishing various purposes, including e.g., transferring the digital image data to a second computerized apparatus having various algorithmic analysis functions operative thereon, including for example pixel intensity analysis, shape recognition, and preview functions, so as to enhance efficiency of the review process. In another embodiment, portions of the algorithmic analysis (and other functions) are performed by the digital processor apparatus on the swallowable apparatus, including selective deletion or omission of data prior to transmission.

公开(公告)号：US09861296B2

公开(公告)日：2018-01-09

申请号：US14554992

申请日：2014-11-26

申请人： West View Research, LLC

发明人： Robert F. Gazdzinski

IPC分类号： A61M31/00 ,  A61B5/07 ,  A61B5/00 ,  A61B1/00 ,  A61B1/04 ,  A61B10/02 ,  A61N2/00 ,  A61N5/10 ,  A61B5/11 ,  A61B10/04 ,  A61M5/145 ,  A61B5/145 ,  A61M5/172 ,  A61B1/06 ,  A61B8/12 ,  A61B8/00 ,  A61B18/20 ,  H04L1/00 ,  A61B6/00 ,  A61B6/03

CPC分类号： A61B5/073 ,  A61B1/00006 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00029 ,  A61B1/00032 ,  A61B1/00036 ,  A61B1/00156 ,  A61B1/00158 ,  A61B1/041 ,  A61B1/043 ,  A61B1/0684 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/11 ,  A61B5/1107 ,  A61B5/14546 ,  A61B5/411 ,  A61B5/42 ,  A61B5/4255 ,  A61B5/4839 ,  A61B5/7225 ,  A61B5/7232 ,  A61B5/7257 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4494 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/445 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/56 ,  A61B10/02 ,  A61B10/04 ,  A61B18/20 ,  A61M5/145 ,  A61M5/1723 ,  A61M31/002 ,  A61M2005/1726 ,  A61M2202/07 ,  A61M2205/10 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2210/1042 ,  A61N2/002 ,  A61N5/1007 ,  A61N5/1014 ,  A61N2005/1005 ,  H04L1/004

摘要： An improved device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to deliver one or more therapeutic agents. In one embodiment, the probe communicates wirelessly with a portable electronic device outside the organism in order to receive commands to deliver the therapeutic agent, or perform other functions while the probe is within the intestinal tract.

公开(公告)号：US20170165500A1

公开(公告)日：2017-06-15

申请号：US14803427

申请日：2015-07-20

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Ryan Flynn ,  Xiaodong WU ,  Yunlong Liu ,  Quentin Adams ,  Drake Edwards ,  Shirin Enger ,  Brittany Rae Woodin ,  Hossein Dadkhan

IPC分类号： A61N5/10

CPC分类号： A61N5/1002 ,  A61N5/1007 ,  A61N5/1027 ,  A61N5/103 ,  A61N5/1044 ,  A61N2005/1005 ,  A61N2005/1094

摘要： Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT). In an aspect, the catheter system can utilize paddle-based RSBT. Further provided are methods and systems for helical RSBT.

公开(公告)号：US20170049591A1

公开(公告)日：2017-02-23

申请号：US15237270

申请日：2016-08-15

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： CLAUDE O. CLERC ,  JOHN A. HINGSTON ,  MARK RIVARD ,  ARNOLD M. HERSKOVIC

IPC分类号： A61F2/88

CPC分类号： A61F2/88 ,  A61F2210/0095 ,  A61F2220/005 ,  A61F2220/0075 ,  A61N5/1001 ,  A61N5/1002 ,  A61N5/1014 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1008 ,  A61N2005/1023

摘要： This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device includes a stent having a plurality of longitudinally extending filaments. The stent also has an inner surface and an outer surface and a plurality of tubular members extending along the stent. Each of the plurality of tubular members is coupled with one or more of the plurality of longitudinally extending filaments and each of the plurality of tubular members is configured to accept a radioactive element, a spacer or both.

摘要翻译： 本公开提供用于医疗设备的设计，材料，制造方法和使用替代物。 示例性医疗装置包括具有多个纵向延伸细丝的支架。 支架还具有内表面和外表面以及沿着支架延伸的多个管状构件。 多个管状构件中的每一个与所述多个纵向延伸的细丝中的一个或多个连接，并且所述多个管状构件中的每一个构造成接受放射性元件，间隔物或两者。

公开(公告)号：US20150208901A1

公开(公告)日：2015-07-30

申请号：US14586839

申请日：2014-12-30

申请人： West View Research, LLC

发明人： Robert F. Gazdzinski

IPC分类号： A61B1/00 ,  A61B5/00 ,  A61B1/04 ,  A61B5/07

CPC分类号： A61B1/041 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00032 ,  A61B1/00036 ,  A61B1/00041 ,  A61B1/0005 ,  A61B1/00059 ,  A61B1/00156 ,  A61B1/00158 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/273 ,  A61B1/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/073 ,  A61B5/411 ,  A61B5/4255 ,  A61B5/7232 ,  A61B5/7282 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/56 ,  A61B10/02 ,  A61B18/20 ,  A61B2562/162 ,  A61N2/002 ,  A61N5/1014 ,  A61N2005/1005 ,  G06F19/00 ,  G06T7/20 ,  H04L1/004

摘要： Computerized information processing methods for processing data from a medical device, such as an ingestible probe. In one embodiment, the method includes processing data obtained by the probe so as to produce a plurality of image frames, and further processing the frames to identify a plurality of frames of potential interest to a reviewer based on at least an evaluation of portions of the frame(s) such as pixels or groups of pixels, and using the identified frames to form a preview of the entire data set. In one implementation, the processing of the data includes processing of pixel intensity and/or color (which can be correlated to various physiologic conditions) to help identify the frames of potential interest.

摘要翻译： 用于处理来自诸如可摄入探针的医疗装置的数据的计算机化信息处理方法。 在一个实施例中，该方法包括处理由探测器获得的数据，以便产生多个图像帧，并且进一步处理该帧以基于至少一个评估部分的评估来识别评论者潜在的多个帧 诸如像素或像素组之类的帧，以及使用所识别的帧来形成整个数据集的预览。 在一个实现中，数据的处理包括像素强度和/或颜色（其可以与各种生理条件相关联）的处理，以帮助识别潜在感兴趣的帧。

公开(公告)号：US20150112160A1

公开(公告)日：2015-04-23

申请号：US14475429

申请日：2014-09-02

申请人： West View Research, LLC

发明人： Robert F. Gazdzinski

IPC分类号： A61B5/07 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/073 ,  A61B1/00006 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00029 ,  A61B1/00032 ,  A61B1/00036 ,  A61B1/00156 ,  A61B1/00158 ,  A61B1/041 ,  A61B1/043 ,  A61B1/0684 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/11 ,  A61B5/1107 ,  A61B5/14546 ,  A61B5/411 ,  A61B5/42 ,  A61B5/4255 ,  A61B5/4839 ,  A61B5/7225 ,  A61B5/7232 ,  A61B5/7257 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4494 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/445 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/56 ,  A61B10/02 ,  A61B10/04 ,  A61B18/20 ,  A61M5/145 ,  A61M5/1723 ,  A61M31/002 ,  A61M2005/1726 ,  A61M2202/07 ,  A61M2205/10 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2210/1042 ,  A61N2/002 ,  A61N5/1007 ,  A61N5/1014 ,  A61N2005/1005 ,  H04L1/004

摘要： An improved endoscopic device which is introduced into, for example, the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, pressure data, or ultrasonic waveform data. In one embodiment, the device includes one or more pressure sensing apparatus configured to enable measurement of pressure resulting from, for instance, peristaltic contractions within the intestinal tract, including transmission of pressure data as a function of time off of the device via a wireless interface while the device is within the intestinal tract.

摘要翻译： 一种改进的内窥镜装置，其被引入例如生物体的肠道并且其自主操作，适于获得和存储或传输一种或多种类型的数据，例如视觉图像数据，激光自发荧光数据，压力数据 ，或超声波波形数据。 在一个实施例中，该装置包括一个或多个压力感测装置，其被配置为能够测量由例如肠道内的蠕动收缩引起的压力，包括作为经由无线接口的设备的时间的函数的压力数据的传输 而装置在肠道内。

公开(公告)号：US20140275714A1

公开(公告)日：2014-09-18

申请号：US14198793

申请日：2014-03-06

申请人： THE CLEVELAND CLINIC FOUNDATION

发明人： John Greskovich, JR.

IPC分类号： A61N5/10

CPC分类号： A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1005 ,  A61N2005/1094

摘要： A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

摘要翻译： 提供了用于将辐射递送到天然组织的目标部分的系统。 该系统包括具有主导管主体的导管。 主导管主体包括外导管表面和限定纵向定向内腔的内导管表面。 内腔在纵向间隔开的在导管内表面和外导管表面之间横向延伸的近端和远端导管面表面延伸。 护套覆盖外导管表面的至少一部分。 护套包括从远端导管面表面的一部分基本上纵向远端突出的锥形部分。 多个管延伸穿过内腔朝向远端导管面表面。 多个管中的每个管被配置成选择性地引导辐射源暴露于天然组织的目标部分。

公开(公告)号：US08636637B2

公开(公告)日：2014-01-28

申请号：US13571495

申请日：2012-08-10

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US08273006B2

公开(公告)日：2012-09-25

申请号：US12386100

申请日：2009-04-14

申请人： Paul Lubock ,  Michael L. Jones

发明人： Paul Lubock ,  Michael L. Jones

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61B2017/3419 ,  A61N2005/1005

摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.

摘要翻译： 公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如， 癌症。 这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在处理位置部分地环绕辐射源以控制来自辐射源的辐射。 该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时辐射未被辐射屏蔽部件屏蔽的组织。 体现本发明特征的装置可包括密封构件，该密封构件位于靠近处理位置的装置的轴上的位置处，以密封通向体腔的通道。