公开(公告)号：US20100293807A1

公开(公告)日：2010-11-25

申请号：US12740184

申请日：2008-10-29

申请人： Yossi Bar-El ,  Giora Arbel ,  Meir Stern

发明人： Yossi Bar-El ,  Giora Arbel ,  Meir Stern

IPC分类号： F26B21/08 ,  F26B21/00 ,  F26B5/00

CPC分类号： F26B21/12 ,  F26B21/004 ,  F26B21/08 ,  F26B21/14

摘要： Apparatus is provided, including one or more drug patches (20) and a surface (22) configured to hold the one or more drug patches. A housing (24) is shaped to define one or more gas inflow openings (30) that are configured to facilitate drying of the patches by directing a flow of a gas toward the patches, a midline of the flow being at an angle of less than 20 degrees from a normal to the surface. Other embodiments are also described.

摘要翻译： 提供了包括一个或多个药物贴片（20）和被配置为保持一个或多个药物贴片的表面（22）的装置。 壳体（24）被成形为限定一个或多个气体流入开口（30），其被构造成便于通过将气流朝着贴片引导来促进贴片的干燥，流体的中线处于小于 从正常到表面20度。 还描述了其它实施例。

公开(公告)号：US08133505B2

公开(公告)日：2012-03-13

申请号：US12357283

申请日：2009-01-21

申请人： Meir Stern ,  Galit Levin

发明人： Meir Stern ,  Galit Levin

IPC分类号： A61K38/23 ,  A61K9/70 ,  C07K14/585 ,  A61L15/16 ,  A61F13/02

CPC分类号： A61K9/0021 ,  A61F2013/00646 ,  A61K9/703

摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.

摘要翻译： 本发明提供了一种用于透皮递送干燥或冻干的药物组合物及其使用方法的系统。 该系统包括用于促进产生亲水微通道的药剂的透皮递送的装置和包含治疗活性剂的贴剂。 本发明可用于透皮递送亲水剂，特别是高分子量蛋白质。

公开(公告)号：US07415306B2

公开(公告)日：2008-08-19

申请号：US11116065

申请日：2005-04-27

申请人： Galit Levin ,  Dorit Daniel

发明人： Galit Levin ,  Dorit Daniel

IPC分类号： A61N1/30

CPC分类号： A61K9/7007 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/439 ,  A61N1/0476 ,  A61N1/0496 ,  A61N1/325 ,  A61N1/327

摘要： The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof. The system includes an anti-emetic hydrophilic adhesive composition of a hydrophilic polymer and hydrophilic anti-emetic agent, a patch containing at least one hydrophilic layer of the composition, and an apparatus that generates hydrophilic micro-channels in skin of a subject using the patch or composition. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of hydrophilic anti-emetic agents.

摘要翻译： 本发明提供了一种用于亲水性抗呕吐剂的透皮递送系统及其使用方法。 该系统包括亲水性聚合物和亲水性抗呕吐剂的抗唾液酸亲水性粘合剂组合物，包含组合物的至少一个亲水层的贴剂，以及使用该贴剂在受试者的皮肤中产生亲水性微通道的装置 或组成。 该系统优选地避免使用渗透促进剂，并且特别可用于亲水性抗呕吐剂的透皮递送。

公开(公告)号：US07395111B2

公开(公告)日：2008-07-01

申请号：US11116056

申请日：2005-04-27

申请人： Galit Levin ,  Meir Stern ,  Dorit Daniel

发明人： Galit Levin ,  Meir Stern ,  Dorit Daniel

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61K9/703 ,  A61K9/7084 ,  A61N1/044 ,  A61N1/40

摘要： The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.

摘要翻译： 本发明提供了一种用于透皮递送水不溶性药物的方法及使用该系统的方法。 该系统包括增加药物在水溶液中的溶解度的水不溶性药物和载体分子的药物组合物，含有该溶液的药物组合物和在受试者皮肤区域中产生亲水性微通道的装置，其使用 组成或补丁。 该系统优选地避免使用渗透增强剂，并且特别可用于类固醇的透皮递送。

公开(公告)号：US20120041431A1

公开(公告)日：2012-02-16

申请号：US13203436

申请日：2010-02-22

申请人： Galit Levin ,  Zev Sohn

发明人： Galit Levin ,  Zev Sohn

IPC分类号： A61B18/18

CPC分类号： A61N1/40 ,  A61B18/14 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/143 ,  A61N1/328

摘要： A method is provided for reducing a wrinkle on a skin surface (42). The method includes identifying a person having a skin surface (42) with a wrinkle and in response to identifying the person, positioning at respective sites on the skin surface (42) an array (44) of electrodes (60) coupled to an energy source (46). While the electrodes (60) are at the respective sites: during a first time period, applying energy from the energy source (46) to drive the electrodes (60) to apply radio frequency (RF) current at a first voltage, capable of ablating an epidermal layer of the skin; and during a second time period, applying energy from the energy source (46) to drive the electrodes (60) to apply current at a second voltage, lower than the first voltage. Other embodiments are also described.

摘要翻译： 提供了一种用于减少皮肤表面（42）上的皱纹的方法。 该方法包括识别具有皱纹的皮肤表面（42）的人，并且响应于识别人，在皮肤表面（42）上的相应位置定位耦合到能量源的电极阵列（44） （46）。 当电极（60）处于相应位置时：在第一时间段期间，从能量源（46）施加能量以驱动电极（60）以在能够消融的第一电压处施加射频（RF）电流 表皮层皮肤; 并且在第二时间段期间，从能量源（46）施加能量以驱动电极（60）以比第一电压低的第二电压施加电流。 还描述了其它实施例。

公开(公告)号：US20110150976A1

公开(公告)日：2011-06-23

申请号：US13061466

申请日：2009-09-10

申请人： Galit Levin ,  Hagit Sacks ,  Meir Stern ,  Galit Mazooz

发明人： Galit Levin ,  Hagit Sacks ,  Meir Stern ,  Galit Mazooz

IPC分类号： A61K31/727 ,  A61K31/715 ,  A61K9/70 ,  A61P7/02 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7084 ,  A61K31/702

摘要： The present invention relates to a system for facilitating transdermal delivery of oligosaccharides, The system includes an apparatus that generates micro-channels in the skin of a subject and a skin patch. The patch includes a pharmaceutical composition containing an active agent of an oligosaccharide. Particularly, the oligosaccharide has 5 to 20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.

摘要翻译： 本发明涉及促进寡糖透皮递送的系统。该系统包括在受试者的皮肤和皮肤贴片中产生微通道的装置。 贴剂包括含有寡糖活性剂的药物组合物。 特别地，寡糖具有5〜20个具有抗凝血活性的单糖，例如五糖。 该系统能够将低聚糖输送到血液循环中用于治疗血栓栓塞性疾病。

公开(公告)号：US20080114281A1

公开(公告)日：2008-05-15

申请号：US10597431

申请日：2005-01-25

申请人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

发明人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

IPC分类号： A61K31/70 ,  A61P43/00 ,  A61N1/30

CPC分类号： A61N1/327

摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

摘要翻译： 本发明涉及用于寡核苷酸或多核苷酸的皮内或透皮递送的系统及其使用方法。 特别地，本发明涉及一种系统，其包括与包含寡核苷酸或多核苷酸的药物组合物结合的受试者皮肤中产生微通道的装置，其中所述寡核苷酸或多核苷酸可以通过微量载体递送至生物体， 频道 本发明的系统和方法实现由多核苷酸编码的靶蛋白的表达，因此可用于免疫和基因治疗。

公开(公告)号：US07123957B2

公开(公告)日：2006-10-17

申请号：US10771909

申请日：2004-02-03

申请人： Zohar Avrahami

发明人： Zohar Avrahami

IPC分类号： A61N1/30 ,  A61M31/00

CPC分类号： A61N1/327 ,  A61N1/30 ,  A61N1/325

摘要： A device for ablating the stratum corneum epidermidis of a subject, including a plurality of electrodes, which are applied to the subject's skin at respective points. A power source applies electrical energy between two or more of the plurality of electrodes, in order to cause ablation of the stratum corneum primarily in an area intermediate the respective points.

公开(公告)号：US20050119605A1

公开(公告)日：2005-06-02

申请号：US10511966

申请日：2004-12-30

申请人： Ze'ev Sohn

发明人： Ze'ev Sohn

IPC分类号： A61B18/14 ,  A61B18/18 ,  A61N20060101 ,  A61N1/30 ,  A61N1/32

CPC分类号： A61N1/327 ,  A61B18/14 ,  A61B2018/00208 ,  A61B2018/00452 ,  A61B2018/1467 ,  A61B2018/1861 ,  A61M37/00 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/306

摘要： Apparatus (20) for application to skin of a subject is provided. The apparatus includes a board (30) having a first surface and a second surface, the first surface including a plurality of ablation electrodes (41), which are adapted to be applied to the skin, and the second surface including one or more contact pads (32), each one of the contact pads electrically coupled to at least one of the ablation electrodes. The apparatus further includes one or more driving electrodes (28). An energy applicator (e.g., motor 22), coupled to the driving electrodes, is adapted to pass the driving electrodes over the contact pads. A power source (e.g., power unit 102) is adapted to drive a current from the driving electrodes, to the contact pads, and to the ablation electrodes. The current is capable of ablating at least a portion of stratum corneum of the skin in a vicinity of the ablation electrodes, so as to facilitate transdermal transport of a substance.

摘要翻译： 提供了用于受试者皮肤的装置（20）。 所述装置包括具有第一表面和第二表面的板（30），所述第一表面包括适于施加到皮肤的多个消融电极（41），所述第二表面包括一个或多个接触垫 （32），所述接触垫中的每一个电耦合到所述消融电极中的至少一个。 该装置还包括一个或多个驱动电极（28）。 耦合到驱动电极的能量施加器（例如，马达22）适于使驱动电极穿过接触垫。 电源（例如，功率单元102）适于驱动来自驱动电极，接触焊盘和消融电极的电流。 该电流能够在消融电极附近烧蚀皮肤的角质层的至少一部分，以促进物质的透皮转运。

公开(公告)号：US20110129522A1

公开(公告)日：2011-06-02

申请号：US13054908

申请日：2009-07-21

申请人： Keren Mevorat-Kaplan ,  Galit Levin ,  Hagit Sacks ,  Meir Stern

发明人： Keren Mevorat-Kaplan ,  Galit Levin ,  Hagit Sacks ,  Meir Stern

IPC分类号： A61K38/26 ,  A61K38/22 ,  A61K9/70 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K9/7084 ,  A61K38/2278

摘要： A transdermal patch formulation of a viscous liquid that includes an active agent of incretin or incretin mimetic peptide, a stabilizer, a buffer, a water soluble thickening agent, and a pharmaceutically acceptable carrier. Also, a patch adapted for transdermal delivery of the active agent and having a drug reservoir compartment of the transdermal patch formulation and a system for facilitating transdermal delivery of the active agent through the skin of a subject. The system includes the patch and an apparatus capable of generating a plurality of micro-channels in an area on the subject's skin. The patch and apparatus are used in methods of treatment for reducing blood glucose level, lowering plasma glucagon levels, reducing food intake, or reducing gastric motility in a subject in need of the same by extending the release of the incretin or incretin mimetic peptide in the subject.

摘要翻译： 粘性液体的透皮贴剂制剂，其包含肠降血糖素或模拟肽肠降胆固醇的活性剂，稳定剂，缓冲液，水溶性增稠剂和药学上可接受的载体。 而且，适于透皮递送活性剂并具有透皮贴剂制剂的药物储存室的贴剂以及促进活性剂通过受试者皮肤透皮递送的系统。 该系统包括贴片和能够在受试者皮肤上的区域中产生多个微通道的装置。 贴剂和装置用于治疗方法中，以降低血糖水平，降低血浆胰高血糖素水平，降低食物摄入量，或减少需要相同受试者的胃动力，从而延长肠内营养素或肠促胰岛素素模型肽的释放 学科。