公开(公告)号：US08257732B2

公开(公告)日：2012-09-04

申请号：US13115699

申请日：2011-05-25

申请人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

发明人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

IPC分类号： A61L15/14 ,  A61K9/14 ,  A61F13/00 ,  A61F13/37 ,  A61L15/16 ,  A61L15/18

CPC分类号： A61F13/534 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2400/04

摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

公开(公告)号：US08252344B2

公开(公告)日：2012-08-28

申请号：US10939869

申请日：2004-09-13

申请人： Francis X. Hursey

发明人： Francis X. Hursey

IPC分类号： A61L15/16 ,  A61L15/08 ,  A61L15/00 ,  A61L15/18 ,  A61L15/42 ,  A61F13/00 ,  A61F13/15 ,  A61K9/14 ,  B01J29/04

CPC分类号： A61L26/0004 ,  A61K33/00 ,  A61L2400/04

摘要： A composition for promoting the formation of clots in blood comprises a zeolite and a binder. The zeolite is adjusted to have a specific moisture content. Processes by which the moisture content is adjusted include drying, re-hydrating, and combinations of drying and re-hydrating. A method of forming the composition comprises the steps of providing a zeolite and adjusting the moisture content such that upon application of the composition to a wound, a heat of hydration is reduced and heat transferred to the wound is reduced. A method of clotting blood flowing from a wound comprises the steps of applying the zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time, the zeolite having an adjusted moisture content and being capable of producing a controllable exothermic effect on the wound.

摘要翻译： 用于促进血液中凝块形成的组合物包括沸石和粘合剂。 调节沸石以具有特定的含水量。 调节含水量的方法包括干燥，再水合，以及干燥和再水化的组合。 形成组合物的方法包括以下步骤：提供沸石并调节水分含量，使得当将组合物施用于伤口时，水合热减少，并且传递到伤口的热量减少。 凝血从伤口流出的血液的方法包括以下步骤：将沸石施加到伤口并保持沸石与伤口接触预定的时间量，沸石具有调节的水分含量并且能够产生可控制的放热 对伤口的影响。

公开(公告)号：US20080097271A1

公开(公告)日：2008-04-24

申请号：US11584079

申请日：2006-10-20

申请人： Denny Lo ,  Raymond Huey

发明人： Denny Lo ,  Raymond Huey

IPC分类号： A61F13/40

CPC分类号： A61F13/00034 ,  A61F2013/00463 ,  A61F2013/00472 ,  A61F2013/00548 ,  A61F2013/00561 ,  A61F2013/00902 ,  A61F2013/0091 ,  A61L15/18 ,  A61L2400/04

摘要： A hemostatic agent applicable to a bleeding wound to promote the clotting of blood comprises a first component and a second component, both components being in particle form and commingled with each other, and both components having hemostatic properties. A device incorporating such an agent comprises a receptacle for retaining the agent in particulate form therein. At least a portion of the receptacle is defined by a mesh having openings therein through which the blood may flow to come into contact with the particles of the hemostatic agent. A pad for controlling the flow of blood from a bleeding wound comprises a mesh structure and the hemostatic agent retained therein. A bandage applicable to a bleeding wound is defined by a substrate, a mesh mounted on the substrate, and the hemostatic agent retained in the mesh.

摘要翻译： 适用于出血伤口以促进血液凝结的止血剂包括第一组分和第二组分，两种组分均为颗粒形式并且彼此混合，并且两种组分均具有止血性质。 包含这种试剂的装置包括用于将试剂保持在其中的颗粒形式的容器。 容器的至少一部分由其中具有开口的网眼限定，血液可以通过该网孔流动以与止血剂的颗粒接触。 用于控制来自出血性伤口的血液流动的垫包括网状结构，并且止血剂保留在其中。 适用于出血性伤口的绷带由基材，安装在基底上的网和保留在网中的止血剂限定。

公开(公告)号：US20070275073A1

公开(公告)日：2007-11-29

申请号：US11590427

申请日：2006-10-30

申请人： Raymond Huey ,  Denny Lo ,  Daniel J. Burns

发明人： Raymond Huey ,  Denny Lo ,  Daniel J. Burns

IPC分类号： A61K9/14

CPC分类号： A61F13/534 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2400/04

摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

公开(公告)号：US20120321691A1

公开(公告)日：2012-12-20

申请号：US13593310

申请日：2012-08-23

申请人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

发明人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

IPC分类号： A61K33/06 ,  A61P7/04 ,  A61P29/00 ,  A61K33/34 ,  A61P31/10 ,  A61P31/00 ,  A61K33/38 ,  A61L15/18 ,  A61P31/04

CPC分类号： A61F13/534 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2400/04

摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

公开(公告)号：US08257731B2

公开(公告)日：2012-09-04

申请号：US12555876

申请日：2009-09-09

申请人： Jeffry Horn ,  Raymond Huey

发明人： Jeffry Horn ,  Raymond Huey

IPC分类号： A61L15/14 ,  A61L15/16 ,  A61L15/18 ,  A61K9/14 ,  A61F13/00

CPC分类号： A61L15/18 ,  A61L15/42

摘要： An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining molecular sieve material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a rigid or semi-rigid support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attached to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate molecular sieve material is in direct contact with blood.

摘要翻译： 用于促进血液凝固和控制出血的装置包括用于将分子筛材料保持为颗粒形式的容器。 用于控制出血的垫包括网状结构和附接到网状结构的刚性或半刚性支撑件，以便于对垫和伤口施加压力。 适用于流血创伤的绷带包括网状结构和附着到网状结构的柔性基底，该基底是可以粘合地附着以覆盖伤口的布或塑料构件。 在任何实施例中，容器或网状结构的至少一部分由其中具有开口的网格限定，并且至少一部分颗粒分子筛材料与血液直接接触。

公开(公告)号：US08202532B2

公开(公告)日：2012-06-19

申请号：US12611830

申请日：2009-11-03

申请人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

发明人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

IPC分类号： A61L15/14 ,  A61L15/16 ,  A61K9/14 ,  A61F13/00

CPC分类号： A61L15/18 ,  A61F13/00063 ,  A61F2013/00472 ,  A61F2013/00548 ,  A61F2013/00744 ,  A61L15/44 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04

摘要： Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding wound when the device is in particle form and the clay material can promote hemostasis.

摘要翻译： 公开了用于促进包含粘土材料和脱模剂的血液凝血的装置。 在一些实施例中，粘土材料设置在基材内，脱模剂设置在网内。 脱模剂可以构造成当装置处于颗粒形式时与出血的伤口直接接触，并且粘土材料可以促进止血。

公开(公告)号：US20100233248A1

公开(公告)日：2010-09-16

申请号：US12581782

申请日：2009-10-19

申请人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

发明人： Raymond J. Huey ,  Denny Lo ,  Daniel J. Burns ,  Giacomo Basadonna ,  Francis X. Hursey

IPC分类号： A61K9/70 ,  A61K33/06 ,  A61P17/02 ,  A61P7/04

CPC分类号： A61L15/44 ,  A61F13/00012 ,  A61F13/00063 ,  A61L15/18 ,  A61L15/28 ,  A61L15/425 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2400/04 ,  A61L2400/16

摘要： A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

摘要翻译： 用于促进血液凝结的止血装置包括纱布基底，布置在纱布基底上的粘土材料，以及布置在纱布基底上以粘合粘土材料的多元醇，例如甘油等。 当该装置用于治疗流血的伤口时，至少一部分粘土材料与从伤口发出的血液接触以引起凝血。 可以应用于流血伤口以促进血液凝结的绷带包括安装在其上的柔性基底和纱布基底。 纱布基材包括粘土材料和多元醇。 止血海绵还包括纱布基底和止血材料和多元醇在基底的第一表面上的分散体。

公开(公告)号：US07595429B2

公开(公告)日：2009-09-29

申请号：US10939687

申请日：2004-09-13

申请人： Francis X. Hursey

发明人： Francis X. Hursey

IPC分类号： A61L15/00

CPC分类号： A61L15/18 ,  A61K33/00 ,  A61K33/06 ,  A61K35/02 ,  A61K45/06 ,  A61L26/0004 ,  A61L2400/04 ,  A61K2300/00

摘要： A composition for promoting the formation of clots in blood comprises a binder and a zeolite disposed in the binder, the zeolite having an adjusted calcium content. A method of forming a blood-clotting composition comprises the steps of providing a zeolite, combining the zeolite with a binder, and adjusting a calcium content of the zeolite to have an amount of calcium such that upon application of the composition to a wound, a heat of hydration is reduced and thereby heat transferred to the wound is reduced. A method of clotting blood flowing from a wound comprises the steps of applying a zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time. The zeolite preferably has an adjusted calcium content and is capable of producing a controllable blood clotting effect on the wound.

摘要翻译： 用于促进血液中凝块形成的组合物包括粘合剂和设置在粘合剂中的沸石，所述沸石具有调节的钙含量。 形成凝血组合物的方法包括以下步骤：提供沸石，将沸石与粘合剂组合，以及调节沸石的钙含量以使其具有一定量的钙，使得当将组合物施用于伤口时， 水合热降低，从而传递到伤口的热量减少。 凝血从伤口流出的血液的方法包括以下步骤：将沸石施加到伤口并保持沸石与伤口接触预定的时间。 沸石优选具有调节的钙含量，并且能够对伤口产生可控制的凝血作用。

公开(公告)号：US20090186071A1

公开(公告)日：2009-07-23

申请号：US12417802

申请日：2009-04-03

申请人： Raymond Huey ,  Denny Lo ,  Daniel J. Burns

发明人： Raymond Huey ,  Denny Lo ,  Daniel J. Burns

IPC分类号： A61K9/70 ,  A61K33/34 ,  A61K33/38 ,  A61P17/02

CPC分类号： A61F13/534 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/102 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2400/04

摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。