-
公开(公告)号:US10054532B2
公开(公告)日:2018-08-21
申请号:US15679465
申请日:2017-08-17
申请人: BugLab LLC
CPC分类号: G01N15/06 , C12M41/36 , G01N21/51 , G01N2015/0693
摘要: This invention provides methods and devices to measure particle suspension concentrations in the presence of potential interferents. Particle back-scatter readings are taken at light wavelengths that are absorbed by the medium before interacting with surrounding objects. Source-detector spacings are minimized compared to the mean absorbance path length of light, thereby maximizing the range of sensitivity to particle concentration. Discrimination against potentially interfering particles, such as bubbles, is provided by mapping the signal distribution against the central signal value and/or by the use of statistical measures with reduced dependence on outliers. The methods and devices allow accurate particle concentration readings over a wide range of concentration in environments crowded with potentially interfering objects and in the presence of variable concentrations and sizes of potentially interfering particles.
-
公开(公告)号:US10016489B2
公开(公告)日:2018-07-10
申请号:US15103280
申请日:2014-04-23
申请人: NIZYME, INC.
发明人: Ilana Katsnelson
IPC分类号: A61K38/44 , A61K31/145 , A61K47/48
CPC分类号: A61K38/44 , A61K31/145 , A61K47/60 , C12Y102/01003
摘要: The present invention provides methods and compositions comprising ALDH2 in the treatment of a patient with toxicity resulting from ALDH2 deficiency. The physiological states that may be treated using the present invention include temporary ALDH2 deficiency, such as that seen by alcohol poisoning or an ischemic event.
-
公开(公告)号:US10755192B2
公开(公告)日:2020-08-25
申请号:US15724796
申请日:2017-10-04
摘要: A method and apparatus used for general purpose problem solving using entanglement properties of holography. Intelligent point-based entities having spatial and other electromagnetic properties called DROPLETS [Data-Representative-Object-Particle(s)-Liking-EnTanglement] are generated as avatars, or delegate objects, connected to concrete or abstract data sources representing a situation, event or other problem. Each DROPLET's properties are controlled by changes in the input sources, feedback, changes in itself, and/or changes of other DROPLETS. Coherent rays are introduced and interact with said DROPLETS, generating an INTELLIGENCE WAVEFRONT. Interference patterns are recorded and converted to binary machine codes used as instruction keys to store and lock human readable and/or machine readable content components into a plurality of associative memories. Said content includes waveforms, harmonics, codes, data, and other holograms. Upon recognition of future like-patterns of situations, events and other problems, the appropriate content components, which are dispersed and stored wholistically throughout the system using spread spectrum techniques, are rapidly unlocked, retrieved and presented as solutions or partial solutions. Hardware, software, and hybrid hardware and software embodiments are envisioned.In conclusion, to the inventors' knowledge, there is no precedent in the prior art that is capable of analyzing or solving problems of wide latitude of complexity using the least understood, least recognized, enfoldment properties of the science of holography. In the case of the Holographic Computer System, this enfoldment, or quantum-like entanglement, is made to serve as a practical and effective general purpose problem solving tool.Although the foregoing description contains many specifics, these are not to be construed as limiting the scope of the present invention, but merely as providing certain exemplary embodiments. Similarly, other embodiments of the invention may be devised which do not depart from the spirit or scope of the present invention. The scope of the invention is, therefore, indicated and limited only by the appended claims and their legal equivalents, rather than by the foregoing description. All additions, deletions, and modifications to the invention, as disclosed herein, which fall within the meaning and scope of the claims are encompassed by the present invention.
-
公开(公告)号:US10267801B2
公开(公告)日:2019-04-23
申请号:US14489207
申请日:2014-09-17
申请人: Cytosystems Limited
发明人: Ronald Alfred Laskey
IPC分类号: G01N33/68 , G01N33/574
摘要: This disclosure relates to a diagnostic/prognostic assay for prostate cancer and including kits used in said assay.
-
公开(公告)号:US10105432B2
公开(公告)日:2018-10-23
申请号:US15427976
申请日:2017-02-08
发明人: Simon Urwyler , Markus Haake , Michael Rudolf
IPC分类号: A61K39/104 , C07K14/21 , C07K14/22 , C07K16/12 , A61K39/00
摘要: The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
-
公开(公告)号:US11446592B2
公开(公告)日:2022-09-20
申请号:US16787890
申请日:2020-02-11
发明人: Peter Florez
摘要: Filter devices with a flow director surrounded by a filter element providing a large filter surface area and low fluid volumes for efficient filtration and high recovery of sample fluids. The filter device can be configured with dimensions and sealing surfaces to functionally interact as a pre-filter for common usage disposable filter flasks.
-
公开(公告)号:US10463727B2
公开(公告)日:2019-11-05
申请号:US15897480
申请日:2018-02-15
发明人: Simon Urwyler , Markus Haake , Michael Rudolf
IPC分类号: A61K39/104 , C07K14/21 , C07K14/22 , C07K16/12 , A61K39/00
摘要: The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
-
公开(公告)号:US10107814B2
公开(公告)日:2018-10-23
申请号:US13512585
申请日:2012-01-06
申请人: David Galloway , Nick Coleman
发明人: David Galloway , Nick Coleman
IPC分类号: G01N33/53 , G01N33/574
摘要: The invention provides a method of detecting a subject suffering from, or at risk of suffering from, bladder cancer the method comprising i) providing a body fluid sample isolated from a subject; ii) isolating cells from said sample to provide a cell sample; iii) contacting the sample with a specific binding member capable of binding to a minichromosome maintenance (MCM) polypeptide(s); iv) determining the binding of said specific binding member to the cell sample; v) counting those cells in said cell sample which bound to said specific binding member to provide a cell count; vi) determining, based on the cell count, whether the subject has, or is at risk of having, bladder cancer.
-
公开(公告)号:US11274327B2
公开(公告)日:2022-03-15
申请号:US16656002
申请日:2019-10-17
申请人: Affymetrix, Inc.
发明人: Yuker Wang , Keith W. Jones , Ronald J. Sapolsky
IPC分类号: C12Q1/6832 , C12N15/10 , C12Q1/6806 , C12Q1/6876 , C12P19/34 , C12P19/28 , C12Q1/6811
摘要: Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides. In some aspects the precursor is amplified and nicking enzymes are used to separate the full length probes from the amplification products. The methods enable the preparation of single stranded DNA probes of defined sequence and length that are suitable for use in target detection assays.
-
公开(公告)号:US10906981B2
公开(公告)日:2021-02-02
申请号:US14906259
申请日:2014-07-17
IPC分类号: G01N33/66 , C07K16/28 , C07K14/475
摘要: Provided herein are compositions, kits, methods and systems related to administering a structure that crosses the blood brain barrier (BBB) along with a monosaccharide, either simultaneously or consecutively. The structure may be, for example an antibody or fusion antibody that binds to an insulin receptor.
-
-
-
-
-
-
-
-
-