公开(公告)号：US11739308B2

公开(公告)日：2023-08-29

申请号：US16493464

申请日：2018-03-15

申请人： The Broad Institute, Inc. ,  Massachusetts Institute of Technology

发明人： David Benjamin Turitz Cox ,  Neena Pyzocha ,  Feng Zhang

IPC分类号： C12N9/22 ,  C12N15/86

CPC分类号： C12N9/22 ,  C12N15/86 ,  C12N2310/20 ,  C12N2800/30

摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

公开(公告)号：US11630103B2

公开(公告)日：2023-04-18

申请号：US16325807

申请日：2017-08-17

申请人： The Broad Institute, Inc. ,  Massachusetts Institute of Technology ,  The General Hospital Corporation

发明人： Alexandra-Chloé Villani ,  Rahul Satija ,  Aviv Regev ,  Nir Hacohen

IPC分类号： G01N33/50 ,  G01N33/68 ,  C12N5/078

摘要： The present invention provides isolated immune cells, immune cell populations and compositions, as well as markers, marker signatures and molecular targets characterising the immune cells. The cell products, substances, compositions, markers, marker signatures, molecular targets, kits of parts and methods of the present invention provide for new ways to characterise, evaluate and modulate the immune system and immune responses.