-
公开(公告)号：US20230181588A1
公开(公告)日：2023-06-15
申请号：US18047456
申请日：2022-10-18
申请人： YALE UNIVERSITY
发明人： Anton Bennett , Jonathan Ellman , Haya Jamali , Karen S. Anderson , Elias Lolis , Denton Hoyer
IPC分类号： A61K31/519 , A61K31/517 , C07D239/78 , C07D471/04 , C07D491/052 , C07D495/04
CPC分类号： A61K31/519 , A61K31/517 , C07D239/78 , C07D471/04 , C07D491/052 , C07D495/04
摘要： The present invention provides compounds and methods for treating MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.
-
公开(公告)号：US20150105351A1
公开(公告)日：2015-04-16
申请号：US14509301
申请日：2014-10-08
申请人： YALE UNIVERSITY
IPC分类号： C07D471/04 , C07D407/12 , A61K45/06 , C07D403/12 , C07D239/54 , A61K31/513
CPC分类号： C07D471/04 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/12 , C07D407/12 , A61K2300/00
摘要： The present invention is directed to novel nanomolar and picomolar inhibitors of HIV reverse transcriptase, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV-1 and HIV-2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及HIV逆转录酶的新型纳摩尔和皮摩尔抑制剂，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别包括HIV-1和HIV-2和/或继发性疾病状态的耐药菌株，以及 /或由于HIV感染而发生的病症。
-
公开(公告)号：US11504373B2
公开(公告)日：2022-11-22
申请号：US16954514
申请日：2018-12-18
申请人： YALE UNIVERSITY
发明人： Anton Bennett , Jonathan Ellman , Haya Jamali , Karen S. Anderson , Elias Lolis , Denton Hoyer
IPC分类号： A61K31/519 , A61K31/517 , C07D239/78 , C07D471/04 , C07D491/052 , C07D495/04
摘要： The present invention provides compounds and methods for treating, ameliorating, and/or preventing a MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.
-
公开(公告)号：US09382245B2
公开(公告)日：2016-07-05
申请号：US14509301
申请日：2014-10-08
申请人： YALE UNIVERSITY
IPC分类号： C07D471/04 , C07D239/54 , A61K31/513 , A61K45/06 , C07D403/12 , C07D407/12
CPC分类号： C07D471/04 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/12 , C07D407/12 , A61K2300/00
摘要： The present invention is directed to novel nanomolar and picomolar inhibitors of HIV reverse transcriptase, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV-1 and HIV-2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及HIV逆转录酶的新型纳摩尔和皮摩尔抑制剂，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别包括HIV-1和HIV-2和/或继发性疾病状态的耐药菌株，以及 /或由于HIV感染而发生的病症。
-
公开(公告)号：US20140288017A1
公开(公告)日：2014-09-25
申请号：US14348952
申请日：2012-10-12
申请人： YALE UNIVERSITY
IPC分类号： C07C255/54 , A61K31/4409 , A61K45/06 , C07D239/54 , A61K31/513 , C07D239/553 , A61K31/5377 , A61K31/277 , A61K31/536 , A61K31/505 , C07D251/42 , A61K31/53 , C07D213/69 , A61K31/4412 , C07D487/04 , A61K31/5025 , C07D213/57
CPC分类号： C07C255/54 , A61K31/277 , A61K31/4409 , A61K31/4412 , A61K31/5025 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/57 , C07D213/69 , C07D239/10 , C07D239/54 , C07D239/553 , C07D251/42 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to novel catechol diether compounds, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV 1 and 2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及新颖的儿茶酚二醚化合物，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别是包括HIV 1和2的耐药菌株和/或随后发生的继发性疾病状态和/或病症 的艾滋病毒感染。
-
公开(公告)号：US20240335445A1
公开(公告)日：2024-10-10
申请号：US18589173
申请日：2024-02-27
申请人： YALE UNIVERSITY
发明人： Anton Bennett , Jonathan Ellman , Haya Jamali , Karen S. Anderson , Elias Lolis , Denton Hoyer
IPC分类号： A61K31/519 , A61K31/517 , C07D239/78 , C07D471/04 , C07D491/052 , C07D495/04
CPC分类号： A61K31/519 , A61K31/517 , C07D239/78 , C07D471/04 , C07D491/052 , C07D495/04
摘要： The present invention provides compounds and methods for treating MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.
-
公开(公告)号：US09914709B2
公开(公告)日：2018-03-13
申请号：US14310564
申请日：2014-06-20
申请人： YALE UNIVERSITY
IPC分类号： C07D239/48 , A61K45/06 , A61K31/536 , A61K31/551 , A61K31/53 , C07D251/52 , A61K31/5377 , A61K31/505
CPC分类号： C07D239/48 , A61K31/505 , A61K31/53 , A61K31/536 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D251/52 , A61K2300/00
摘要： The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.
-
公开(公告)号：US09487476B2
公开(公告)日：2016-11-08
申请号：US14348952
申请日：2012-10-12
申请人： YALE UNIVERSITY
IPC分类号： C07C255/54 , A61K31/4409 , A61K45/06 , C07D239/54 , A61K31/513 , C07D239/553 , A61K31/5377 , A61K31/277 , A61K31/536 , A61K31/505 , C07D251/42 , A61K31/53 , C07D239/10 , C07D405/12 , C07D471/04 , A61K31/4412 , A61K31/5025 , C07D213/57 , C07D213/69 , C07D487/04
CPC分类号： C07C255/54 , A61K31/277 , A61K31/4409 , A61K31/4412 , A61K31/5025 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/57 , C07D213/69 , C07D239/10 , C07D239/54 , C07D239/553 , C07D251/42 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to novel catechol diether compounds, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV 1 and 2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.
摘要翻译： 本发明涉及新颖的儿茶酚二醚化合物，其药物组合物及其抑制逆转录酶和治疗HIV感染的方法，特别是包括HIV 1和2的耐药菌株和/或随后发生的继发性疾病状态和/或病症 的艾滋病毒感染。
-
9.发明申请公开(公告)号：US20140378443A1
公开(公告)日：2014-12-25
申请号：US14310564
申请日：2014-06-20
申请人： YALE UNIVERSITY
IPC分类号： C07D239/48 , C07D251/52 , A61K31/505 , A61K31/551 , A61K31/536 , A61K31/5377 , A61K31/53
CPC分类号： C07D239/48 , A61K31/505 , A61K31/53 , A61K31/536 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D251/52 , A61K2300/00
摘要： The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.
摘要翻译： 本发明包括可用于预防或治疗有需要的受试者的HIV-1感染的新型组合物。 本发明还包括在有需要的受试者中预防或治疗HIV-1感染的新方法，所述方法包括向受试者施用有效量的本发明化合物。 在一个实施方案中，受试者进一步施用至少一种另外的治疗剂。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.024 秒)
