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公开(公告)号：US20220088106A1
公开(公告)日：2022-03-24
申请号：US17276272
申请日：2020-06-08
发明人： Jae Kwan HWANG , Chang Hee KIM , Ji Hee YOO
IPC分类号： A61K36/60 , A61K8/9778 , A23L33/00 , A23L33/105 , A23K10/30
摘要： The present disclosure relates to a composition for preventing and treating a muscular disease, or improving muscular function, which contains Cudrania tricuspidata such as a pulverization product or an extract of Cudrania tricuspidata as an active ingredient. The Cudrania tricuspidata according to the present disclosure such as the pulverization product or extract of Cudrania tricuspidata has an effect of increasing the activity of mTOR, which is involved in muscle protein synthesis, and reducing the mRNA expression of MuRF-1 and atrogin-1, which are involved in muscle protein degradation, increases muscle mass and improves muscular function. Therefore, it may be usefully utilized in the prevention, alleviation or treatment of various muscular diseases such as atony, muscular atrophy, muscular dystrophy, muscle degeneration, muscle weakness, cachexia, sarcopenia, etc.
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2.发明授权公开(公告)号：US10646498B2
公开(公告)日：2020-05-12
申请号：US15577098
申请日：2016-05-26
发明人： Jae Kwan Hwang , Chang Hee Kim , Mi-Bo Kim
IPC分类号： A61K31/575 , A61P21/00 , A61K36/03
摘要： A composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract is disclosed. Fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.
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公开(公告)号：US10507224B2
公开(公告)日：2019-12-17
申请号：US15390800
申请日：2016-12-27
发明人： Jae-Kwan Hwang , Mi-Bo Kim , Chang Hee Kim
IPC分类号： A61K36/28 , A61K31/047
摘要： The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, a Siegesbeckia herba extract, or a fraction of the Siegesbeckia herba extract as an active ingredient. Kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1α, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.
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公开(公告)号：US10188690B2
公开(公告)日：2019-01-29
申请号：US15498412
申请日：2017-04-26
发明人： Jae-Kwan Hwang , Bo Kyung Sa , Tae Yoon Kim
IPC分类号： A61K36/00 , A61K36/906 , A61K31/35 , A61K31/352
摘要： The present invention relates to a pharmaceutical composition containing Kaempferia parviflora Wall. Ex. Baker extracts for treating muscle diseases, and more specifically to a pharmaceutical composition containing, as an active ingredient, Kaempferia parviflora Wall. Ex. Baker extracts or flavone compound isolated therefrom for treating muscle diseases or a dietary composition for improving muscle function. Kaempferia parviflora Wall. Ex. Baker extracts or flavone compound isolated therefrom according to the present invention reduces protein catabolism in the muscles and increases muscle cell differentiation and anabolism, and is thus effective for preparing pharmaceutical composition for treating muscle diseases and dietary composition for improving muscle function.
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公开(公告)号：US20240293493A1
公开(公告)日：2024-09-05
申请号：US18002740
申请日：2021-03-11
发明人： Jae Kwan HWANG , Changhee KIM , Yu Kyong WOO
IPC分类号： A61K36/532 , A21D2/36 , A23G3/48 , A23G4/06 , A23L2/52 , A61K8/9789 , A61K31/7048 , A61P21/00 , A61Q19/00
CPC分类号： A61K36/532 , A21D2/36 , A23G3/48 , A23G4/068 , A23L2/52 , A61K8/9789 , A61K31/7048 , A61P21/00 , A61Q19/00 , A61K2236/331 , A61K2236/333 , A61K2236/35 , A61K2236/37 , A61K2800/10
摘要： The present disclosure relates to a composition for alleviating, treating or preventing muscular diseases or improving muscular functions, which contains a Korean mint extract or tilianin as an active ingredient. The Korean mint or tilianin according to the present disclosure has effects of increasing the activity of mTOR, which is involved in muscle protein synthesis, and reducing mRNA expression of MuRF-1 and atrogin-1, which are involved in muscle protein degradation. Accordingly, it can be usefully used for prevention, amelioration or treatment of various muscular diseases such as sarcopenia, muscular atrophy, muscular dystrophy, atony, muscular degeneration, myasthenia, cachexia, etc. by increasing muscle mass and improving muscular functions.
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6.发明申请公开(公告)号：US20190183811A1
公开(公告)日：2019-06-20
申请号：US16322825
申请日：2017-08-03
发明人： Jae Kwan HWANG , Se In LEE , Mi Bo KIM , Chang Hee KIM
CPC分类号： A61K31/01 , A23L33/10 , A23V2002/00 , A61K9/0019 , A61K9/1611 , A61K9/1623 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/4866 , A61P21/00
摘要： The present invention relates to a composition for preventing, treating, or ameliorating muscle disease or regenerating damaged muscles, comprising squalene. More specifically, the squalene of the present invention increases expression of proteins which are associated with muscle protein synthesis and muscle mass increase in muscle cells, inhibits, at an mRNA level, expression of enzymes involved in muscle protein degradation, and has an effect of rapidly restoring damaged muscles. In addition, the present invention relating to a natural product can be safely used without side effects, and thus can be used as medicines, foods, or cosmetics.
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7.发明申请公开(公告)号：US20180318320A1
公开(公告)日：2018-11-08
申请号：US15577098
申请日：2016-05-26
发明人： Jae Kwan HWANG , Chang Hee KIM , Mi-Bo KIM
IPC分类号： A61K31/575 , A61K36/03 , A61P21/00
CPC分类号： A61K31/575 , A61K36/03 , A61P21/00
摘要： The present invention relates to a composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract. According to the present invention, fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, since the composition of the present invention is a natural product, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.
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