公开(公告)号：US20030027168A1

公开(公告)日：2003-02-06

申请号：US10027807

申请日：2001-10-19

申请人： AGY Therapeutics, Inc.

发明人： Li Gan ,  Mirella Gonzalez-Zulueta ,  Kristin Anton ,  Richa Wilson ,  Thorsten Melcher ,  Daniel Chin

IPC分类号： C12Q001/68 ,  C12P019/34

CPC分类号： C12N15/1086

摘要： Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilized RNA interference techniques in the validation process.

摘要翻译： 提供了相关基因和基因功能的方法。 这样的方法通常包括选择似乎与特定细胞状态或活性相关的候选基因，然后验证候选基因在建立这种细胞状态或活性中的作用。 某些方法在验证过程中使用RNA干扰技术。

公开(公告)号：US20030054394A1

公开(公告)日：2003-03-20

申请号：US10229912

申请日：2002-08-27

申请人： AGY Therapeutics, Inc.

发明人： Daniel J. Chin ,  Donna Hendrix ,  Oliver Zhao

IPC分类号： C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

CPC分类号： G16B50/00 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B40/00 ,  Y10S707/99933 ,  Y10S707/99936 ,  Y10S707/99937

摘要： Techniques for facilitating the identification of candidate genes from a plurality of DNA sequences. According to an embodiment of the present invention, techniques are provided for extracting and integrating information from various information sources and results of various analyses, and storing the integrated information in a form which is conducive to identification of candidate genes. The stored information may include results of a homology search for the plurality of DNA sequences, annotative information for the plurality of DNA sequences indicating the biochemical functions and physiological roles of the plurality of DNA sequences, gene expression profile data for the plurality of DNA sequences describing behavioral patterns of the plurality of DNA sequences, results from clustering the plurality of DNA sequences based on time course data as described by the gene expression profile data, and other information.

公开(公告)号：US20030118585A1

公开(公告)日：2003-06-26

申请号：US09983000

申请日：2001-10-17

申请人： AGY Therapeutics

发明人： Sabine Muller ,  Thorsten Melcher ,  Daniel Chin

IPC分类号： A61K039/395

CPC分类号： A61K49/0002

摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of human proteins angiopoietin related protein 2 (ARP-2,) secreted protein acidic, rich in cysteine (SPARC,) c-met proto-oncogene (C-MET,) brevican (BEHAB,) CD-44 antigen (CD-44,) tetraspanin 3 (TSPN3,) pleiotrophin (PTN,) osteopontin (OPN,) vasoactive intestinal peptide receptor-2 (VIPR-2,) and receptor protein tyrosine phosphatase zeta (PTPnull) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPnull, PTPnull SM1 and PTPnull SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.

摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合一种或多种人蛋白质的血管生成素相关蛋白2（ARP-2）分泌的蛋白质，富含半胱氨酸（SPARC）c-met原始蛋白的免疫治疗和免疫成像剂的用途。 癌基因（C-MET，）brevican（BEHAB）CD-44抗原（CD-44）四质蛋白3（TSPN3）多效素（PTN）骨桥蛋白（OPN）血管活性肠肽受体-2（VIPR-2） 和受体蛋白酪氨酸磷酸酶ζ（PTPzeta），用于治疗和观察患者脑肿瘤。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。 本发明还提供蛋白质PTPzeta，PTPzeta SM1和PTPzeta SM2的新型剪接变体。 还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

公开(公告)号：US20020172958A1

公开(公告)日：2002-11-21

申请号：US10001051

申请日：2001-10-31

申请人： AGY Therapeutics, Inc.

发明人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

IPC分类号： C12Q001/68 ,  G01N033/53 ,  G01N033/537 ,  G01N033/543

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

摘要翻译： 本发明鉴定其基因产物对神经系统疾病或神经元损伤具有保护作用的基因。 此外，本发明提供了用于诊断或评估个体对诸如中风的神经元损伤的易感性的方法。 还提供了用于治疗患者的治疗方法，以及用于预防性治疗对各种神经障碍或神经元损伤敏感的个体的方法。 另外，本发明描述了用于鉴定可以被施用以治疗遭受或有遭受这种障碍或损伤风险的个体的药剂的筛选方法。

公开(公告)号：US20020146370A1

公开(公告)日：2002-10-10

申请号：US09816703

申请日：2001-03-23

申请人： AGY THERAPEUTICS

发明人： Sabine Mueller ,  Thorsten Melcher ,  Daniel J. Chin

IPC分类号： A61K051/00 ,  A61M036/14

CPC分类号： A61K51/1093 ,  A61K47/6871 ,  A61K51/1075

摘要： The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to human protein tyrosine phosphatase-zeta (PTPnull) for the treatment and visualization of brain tumors in patients. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

摘要翻译： 本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。 具体地，本发明涉及特异性结合人蛋白质酪氨酸磷酸酶ζ（PTP＆xgr）的免疫治疗和免疫成像剂用于治疗和观察患者脑肿瘤的用途。 本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。