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    Novel azetidinones and their use to inhibit lactamase enzymes that destroy beta-lactam antibiotics
    1.
    发明授权
    Novel azetidinones and their use to inhibit lactamase enzymes that destroy beta-lactam antibiotics 失效
    新的AZETIDINONES及其用于抑制乳酸酶抑制剂降低BETA-LACTAM抗生素

    公开(公告)号：US3816408A

    公开(公告)日：1974-06-11

    申请号：US13549871

    申请日：1971-04-19

    申请人： ALLEN & HANBURYS LTD

    发明人： GLADYCH J ,  HUSSEY C

    IPC分类号： C07D205/085 ,  C07D25/02

    CPC分类号： C07D205/085

    摘要： COMPOUNDS OF THE FORMULA:

    1-R3,3-(R1-CO-NH-),4-R2-AZETIDIN-2-ONE

    IIN WHICH R1 REPRESENTS AN ARYL, ARYLAKYL, OR ARYLOXYALKYL GROUP IN WHICH THE ARYL GROUP OR MOIETY MAY OPTIONALLY BE SUBSTITUTED BY ONE OR MORE ALKYL, ALKOXY, HALOACETAMIDO, NITRO OR AMINO GROUPS OR HALOGEN ATOMS AND THE ALKYL CHAIN MAY OPTIONALLY BE SUBSTITUTED BY AN AZIDO AMINO, CARBOXYL, OR ALKOXY GROUP; OR R1 REPRESENTS A GROUP (IN WHICH Z REPRESENTS H, NH2, OR N3) OF THE FOLLOWING FORMULA:

    THIENYL-CH(-Z)-

    R2 REPRESENTS A PHENYL OR NAPHTYL GROUP WHICH MAY OPTIONALLY BE SUBSTITUTED WITH ONE OR MORE ALKOXY GROUPS OR HALOGEN ATOMS; AND R3 REPRESENTS H OR AN ALKYL GROUP CONTAINING FROM 1 TO 4 CARBON ATOMS OR R3 MAY BE AN ACYL OR ALKOXY CARBONYL GROUP, AND ACID ADDITION SALTS THEREOF, THESE COMPOUNDS INHIBIT LACTAMASE ENZYMES WHICH DESTORY B-LACTAM ANTIBIOTICS.

    Fused thiazines
    5.
    发明授权
    Fused thiazines 失效
    融合了THIAZINES

    公开(公告)号：US3586675A

    公开(公告)日：1971-06-22

    申请号：US3586675D

    申请日：1967-12-15

    申请人： ALLEN & HANBURYS LTD

    发明人： RITCHIE ALEXANDER CRAWFORD ,  HADDOCK RODNEY ERIC

    IPC分类号： C07D513/10 ,  C07D93/08

    CPC分类号： C07D513/10 ,  Y10S514/96 ,  Y10S514/962

    摘要： NOVEL THIAZINE COMPOUNDS OF THE FOLLOWING FORMULAE ARE DISCLOSED

    2-(R4-N(-R5)-),4,5-(-(CH2)N-)(-R1),6-R2,6-R3-6H-1,3-

    THIAZINE,

    2-(R7-N=),3-R6,4,5-(-(CH2)N-)(-R1),6-R2,6-R3-6H-1,3-

    THIAZINE

    THESE COMPOUNDS HAVE ANALGETIC AND ANTI-INFLAMMATORY ACTIVITY. PHARMACEUTICAL COMPOSITIONS CONTAINING THESE THIAZINE COMPOUNDS ARE ALSO DISCLOSED AS WELL AS PROCESSES FOR THE PRODUCTION OF SUCH COMPOUNDS.