公开(公告)号：US3813393A

公开(公告)日：1974-05-28

申请号：US26587972

申请日：1972-06-23

申请人： HOFFMANN LA ROCHE

发明人： ANDREWS K ,  TONG B

IPC分类号： C07D487/04 ,  C07D57/34

CPC分类号： C07D487/04 ,  Y10S514/869

摘要： A NEW CLASS OF PYRIMIDOTRIAZINES IS DESCRIBED HAVING A GENERAL ANTI-INFLAMMARTORY ACTIVITY AND SPECIFIC COMPOUNDS THEREIN ALSO EXHIBIT A DIURETIC ACTIVITY. METHODS FOR THE PREPARATION OF THE INSTANT PYRIMIDOTRIAZINES ARE ALSO DESCRIBED. THE NEW PYRIMIDORTRIAZINES ARE OF THE FOLLOWING FORMULA

WHEREIN R IS A TRIFLUOROMETHYL. LOWER ALKYL, ARYL OR LOWER ARALKYL GROUP, R1 IS A HYDROGEN ATOM OR A LOWER ALKYL, ARYL OR LOWER ARALKYL GROUP, R2 IS A HYDROGEN ATOM AND R3 IS A HYDROGEN ATOM OR A LOWER ALKYL, LOWER ALKENYL, LOWER ALKYLNYL, LOWER CYCLOALKYL, ARYL, LOWER ARALKYL, HYDROXYL, HYDROXY-(LOWER ALKYL) OR ACYL GROUP OR R2 AND R3 EACH REPRESENT A LOWER ALKYL GROUP WHICH MAY BE JOINED DIRECTLY OR THROUGH AN OXYGEN, NITROGEN OR SULFUR ATOM TO FORM WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED TO A 5MEMBERED OR 6-MEMBERED HETEROMONOCYCLIC RING.

3-R1,5-(R2-N(-R3)-),7-R-PYRIMIDO(5,4-E)-AS-TRIAZINE

公开(公告)号：US3759910A

公开(公告)日：1973-09-18

申请号：US3759910D

申请日：1970-12-09

申请人： BAYER AG

发明人： DICKORE K ,  EUE L

IPC分类号： A01N43/90 ,  C07D253/075 ,  C07D487/04 ,  C07D57/34

CPC分类号： C07D253/075 ,  C07D487/04

摘要： NEW 1,2,3,7 - TETRAHYDRO-(1,2,4)TRIAZOLO(3,2-C)(1,2,4)TRIAZINONE-(7) COMPOUNDS OF THE FORMULA

2-R2,2-R3,3-R4,6-R1,7-(O=)-1,2,3,7-TETRAHYDRO-(1,2,4)-

TRIAZOLO(3,2-C)(1,2,4)TRIAZINE

IN WHICH:

R1 IS HYDROGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL, ALKENYL, CYCLOALKYL, ARALKYL OR ARYL; R2 AND R3 INDIVIDUALLY ARE HYDROGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL, ALKENYL, CYCLOALKYL, CYCLOALKENYL OR ARALKYL; AND R2 AND R3 TAKEN TOGETHER, ARE ALKYLENE OF FROM 4 TO 7 RING CARBON ATOMS WHICH MAY CARRY ONE OR MORE ALKYL GROUP SUBSTITUENTS, AND R4 IS HYDROGEN, ALKYL, ALKENYL, ARALKYL OR SUBSTITUTED OR UNSUBSTITUTED SRYL

ARE PREPARED BY A NOVEL SYNTHESIS BY REACTING THE CORRESPONDING DIAMINO DIHYDRO TRIAZINONE COMPOUND WITH AN OXO COMPOUND OF THE FORMULA

R2-CO-R3

IN THE PRESENCE OF A LOWER ALKANOIC ACID. THE NOVEL COMPOUNDS ARE OUTSTANDINGLY EFFECTIVE AS HERBICIDES, E.G., AS SELECTIVE HERBICIDES.

公开(公告)号：US3637687A

公开(公告)日：1972-01-25

申请号：US3637687D

申请日：1970-04-21

申请人： SMITH KLINE FRENCH LAB

发明人： CHOW ALFRED W

IPC分类号： C07D209/40 ,  C07D57/34

CPC分类号： C07D209/40

摘要： THE COMPOUNDS ARE AS-TRAIZINO(5,6-B)INDOLES POLYSUBSTITUTED ON THE BENZENE RING SUBSTITUTED ON THE TRIAZINE RING AT THE 3-POSITION WITH A HYDROXYALKYLAMINO GROUP WHICH HAVE ANTIVIRAL ACTIVITY.

公开(公告)号：US3631040A

公开(公告)日：1971-12-28

申请号：US3631040D

申请日：1969-02-07

申请人： SMITH KLINE FRENCH LAB

发明人： LOEV BERNARD

IPC分类号： C07D487/04 ,  C07D57/34

CPC分类号： C07D487/04

摘要： 1,5-DIHYDRO-2,6-DIPHENYLIMIDAZO(1,2-B) - AS - TRIAZINES ARE PREPARED EITHER BY REACTION OF A PHENYLGLYOXAL AND AMINOGUANIDINE TO GIVE AN AMINOPHENYLTRIAZINE, FURTHER REACTION WITH A PHENACYL BROMIDE, AND REDUCTION WITH BOROHYDRIDE; OR DIRECTLY BY REACTION OF PHENACYL BROMIDE, AMINOGUANIDINE, AND HYDROGEN BROMIDE; AND SUBSEQUENT RING-CLOSURE IN BASE. THE PRODUCTS AE ANTIDEPRSSANTS.

公开(公告)号：US3882112A

公开(公告)日：1975-05-06

申请号：US39864173

申请日：1973-09-19

申请人： UPJOHN CO

发明人： SZMUSZKOVICZ JACOB

IPC分类号： C07D487/04 ,  C07D57/34

CPC分类号： C07D487/04

摘要： Compounds of the formula:

WHEREIN N IS 1 OR 2; WHEREIN R is hydrogen, alkyl of one to three carbon atoms, inclusive, or together

IS PYRROLIDINO, PIPERIDINO, METHYLPIPERAZINO, OR MORPHOLINO; WHEREIN R1 is hydrogen or alkyl as defined above; and wherein R2 and R3 are hydrogen, alkyl as defined above, fluorine, chlorine, bromine, nitro, trifluoromethyl, or alkylthio in which alkyl is defined as above, are prepared by reacting a compound of the formula:

WHEREIN R1, R2, and R3 are defined as above, with sodium hydride and then with

WHEREIN X is chlorine, bromine, or iodine, and n, R or

ARE DEFINED AS ABOVE TO OBTAIN THE COMPOUND OF THE FORMULA ABOVE. The compounds of the formula 11 above and the pharmacologically acceptable acid addition salt thereof have sedative and tranquilizing activity.

摘要翻译： 下式的化合物：

公开(公告)号：US3873543A

公开(公告)日：1975-03-25

申请号：US35772273

申请日：1973-05-07

申请人： EGYT GYOGYSZERVEGYESZETI GYAR

发明人： BERENYI NEE POLDERMANN EDIT ,  PALLOS LASZLO ,  BENKO PAL ,  PETOCZ LUJZA E ,  GOROG PETER ,  BUDAI ZOLTAN ,  KISZELLY ENIKO

IPC分类号： A61K31/53 ,  A61P29/00 ,  A61P31/04 ,  C07D215/42 ,  C07D471/04 ,  C07D57/34

CPC分类号： C07D471/04 ,  C07D215/42

摘要： New 3-substituted as-triazino(5,6-c)quinoline derivatives of the general formula (I)

wherein R represents hydrogen, a C1-4 alkyl group, an aralkyl group containing 1 to 4 carbon atoms in the alkyl chain, pyridyl, or a phenyl group optionally substituted with a halogen, nitro, hydroxy or amino group, R1 and R2 each represent hydrogen, or form together a chemical bond ARE PREPARED AS FOLLOWS: 4-CHLORO-3-NITROQUINOLINE IS REACTED WITH A CARBOXYLIC HYDAZIDE OF THE GENERAL FORMULA (II)

摘要翻译： 通式（I）的新的3-取代三氮杂嗪[5,6-c]喹啉衍生物，其中R表示氢，C1-4烷基，烷基链中含有1至4个碳原子的芳烷基，吡啶基 或任选被卤素，硝基，羟基或氨基取代的苯基，R 1和R 2各自表示氢，或一起形成化学键。制备如下：

公开(公告)号：US3818003A

公开(公告)日：1974-06-18

申请号：US21511872

申请日：1972-01-03

申请人： UPJOHN CO

发明人： SZMUSZKOVICZ J

IPC分类号： C07D243/22 ,  A23K1/16 ,  A61K31/55 ,  A61K31/551 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D243/16 ,  C07D243/18 ,  C07D487/04 ,  C07D57/34

CPC分类号： C07D487/04

摘要： Novel 7-substituted-3,5-dihydro-as-triazino(4,3-a)(1,4)benzodiazepin-2(1H)-ones, 7-substituted-3,5-dihydro-astriazino(4,3-a)(1,4)benzodiazepine-2(1H) -thiones, the 6-oxide derivatives thereof, the intermediate 5-substituted-2,3-dihydro2-thioxo-1H-1,4-benzodiazepine-1-acetic acid alkyl esters, pharmacologically acceptable acid addition salts thereof, and processes for the production thereof. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are central nervous system depressants which are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants. They are also useful as feed additives for increasing growth rate and feed efficiency of livestock and poultry, milk production in mammals and egg production in birds.

摘要翻译： 新的7-取代-3,5-二氢 - 三嗪并[4,3-a] - [1,4]苯并二氮杂-2（1H） - ，7-取代-3,5-二氢 - 4,3-a] [1,4]苯并二氮杂-2（1H） - 噻喃，其6-氧化物衍生物，中间体5-取代-2,3-二氢-2-硫代-1H-1,4-苯并二氮杂 -1-乙酸烷基酯，其药理学上可接受的酸加成盐及其制备方法。 本发明化合物及其药理学上可接受的酸加成盐是可用作镇静剂，安眠药，镇静剂，肌肉松弛剂和抗惊厥药的中枢神经系统抑制剂。 它们也可用作饲料添加剂，用于提高家畜和家禽的生长速度和饲料效率，哺乳动物产奶量和鸡蛋生产量。

公开(公告)号：US3725406A

公开(公告)日：1973-04-03

申请号：US3725406D

申请日：1971-10-12

申请人： UNIV CALIFORNIA

发明人： BOSE E ,  WHITE E

IPC分类号： C07D487/04 ,  C07D57/34

CPC分类号： C07D487/04

摘要： The method of manufacture, method of use and fungicidal active compounds are described herein. The active compounds have the following formula:

D R A W I N G
WHEREIN R can be selected from the group consisting of hydrogen, sodium, potassium and ammonium.

摘要翻译： 本文描述了制造方法，使用方法和杀真菌活性化合物。 活性化合物具有下式：

公开(公告)号：US3466281A

公开(公告)日：1969-09-09

申请号：US3466281D

申请日：1968-07-16

申请人： ALLEN & HANBURYS LTD

发明人： GLADYCH JAN MIECZYSLAW ZYGMUNT ,  HUNT JOHN HAROLD

IPC分类号： A61K31/00 ,  C07D209/38 ,  C07D57/34 ,  A61K9/04

CPC分类号： C07D209/38 ,  A61K31/00

公开(公告)号：US3453274A

公开(公告)日：1969-07-01

申请号：US3453274D

申请日：1967-02-15

申请人： FMC CORP

发明人： MURRIN JULIAN MICHAEL ,  OLSON RAYMOND AUGUST

IPC分类号： C07D57/34

CPC分类号： C07D251/36