公开(公告)号：US3642993A

公开(公告)日：1972-02-15

申请号：US3642993D

申请日：1970-03-05

申请人： ALLEN & HANBURYS LTD

发明人： HARCOURT DAVID N ,  JACK DAVID

IPC分类号： C07D223/16

CPC分类号： C07D223/16

摘要： A PHARMACEUTICAL COMPOSITION COMPRISING 2-METHYL-5PHENYL-1,2-DIHYDRO-3H-BENZAZEPINE, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, IN ASSOCIATION WITH A PHARMACEUTICAL CARRIER. THE UTILITY OF THE COMPOSITION IS TO RELIEVE CONDITIONS ASSOCIATED WITH ANXIETY, TENSION OR THE EMOTIONAL DISTURBANCES.

公开(公告)号：US3458521A

公开(公告)日：1969-07-29

申请号：US3458521D

申请日：1965-07-30

申请人： ALLEN & HANBURYS LTD

发明人： JACK DAVID ,  RITCHIE ALEXANDER CRAWFORD ,  PEEL MERVYN EVAN ,  HARPER NORMAN JAMES

IPC分类号： C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/52 ,  C07D211/70 ,  C07D211/98 ,  C07D29/28 ,  A61K27/00 ,  C07D29/14

CPC分类号： C07D211/52 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/70 ,  C07D211/98 ,  Y10S514/96

公开(公告)号：US3701808A

公开(公告)日：1972-10-31

申请号：US3701808D

申请日：1971-05-11

申请人： ALLEN & HANBURYS LTD

发明人： HARTLEY DAVID ,  LUNTS LAWRENCE HENRY CHARLES ,  JACK DAVID

IPC分类号： C07C275/24 ,  C07C143/74

CPC分类号： C07C275/24

摘要： COMPOUNDS OF THE FORMULA

2-(R3-SO2-N(-R1)-CH2-),4-(R5-NH-CH2-CH(OH)-)PHENOL

WHEREIN R1 IS H ALKYL OF 1 TO 6 CARBON ATOMS; R3 IS ALKYL OF 1 TO 6 CARBON ATOMS, PHENYL OR PHENYL SUBSTITUTED BY LOWER ALKYL AND R5 IS H, ALKYL OF 1 TO 6 CARBON ATOMS, CYCLOPENTYL OR ALKYL OF 1 TO 6 CARBON ATOMS, SUBSTITUTED BY PHENYL, LOWER ALKOXYPHENYL OR PHENOXY; OR PHYSIOLOGICALLY ACCEPTABLE ACID ADDTION SALTS THEREOF. THE COMPOUNDS POSSESS STIMULANT OR BLOCKING ACTIONS ON ADRENERGIC RECEPTORS.

公开(公告)号：US3689524A

公开(公告)日：1972-09-05

申请号：US3689524D

申请日：1970-05-27

申请人： ALLEN & HANBURYS LTD

发明人： JACK DAVID ,  HARTLEY DAVID ,  LUNTS LAWRENCE HENRY CHARLES

IPC分类号： A61K31/165 ,  A61K31/135 ,  A61K31/24 ,  A61K31/60 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C213/00 ,  C07C215/52 ,  C07C227/00 ,  C07C227/18 ,  C07C229/38 ,  C07C231/00 ,  C07C231/02 ,  C07C237/30 ,  C07C275/24 ,  C07C275/40 ,  C07C301/00 ,  C07C303/40 ,  C07C311/08 ,  C07C101/12 ,  C07C101/42 ,  C07C101/72

CPC分类号： C07C255/00 ,  C07C229/38 ,  C07C275/40

摘要： The present invention provides compounds of the general formula I and physiologically acceptable addition salts thereof: IN WHICH R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a benzyl or benzhydryl group; R3 represents a hydrogen atom or a lower alkyl group or R3 represents an arylalkyl or aryloxyalkyl radical, which radicals may optionally be substituted by one or more alkoxy or hydroxyl groups; Z represents a group of formula -(CH2)nY in which n has the value of 0, 1 or 2, and Y represents a hydroxyl radical (except when n has the value O) or an alkoxycarbonyl group of the formula COOR where R represents a hydrogen atom or a lower alkyl group, or Y represents an amido group of formula CONR5R6 in which R5 and R6 are as defined below or a group of formula NR4CONR5R6, or -NR4SO2R7 (in which R4, R5 and R6, which may be the same or different, represent hydrogen atoms or lower alkyl groups and R7 represents a lower alkyl group) except where n O and Y NR4SO2R7, R4 is not hydrogen. Preferably at least one of the groups R1, R2 and R3 is other than hydrogen, particularly when Z represents a -COOR group.

摘要翻译： 本发明提供了通式I的化合物及其生理上可接受的加成盐：

公开(公告)号：US3527762A

公开(公告)日：1970-09-08

申请号：US3527762D

申请日：1966-03-30

申请人： ALLEN & HANBURYS LTD

发明人： JACK DAVID ,  RITCHIE ALEXANDER CRAWFORD ,  CHEESMAN DENNIS GEORGE ,  HARPER NORMAN JAMES

IPC分类号： C07D211/16 ,  C07D211/18 ,  C07D211/52 ,  C07D29/30 ,  C07D29/36

CPC分类号： C07D211/16 ,  C07D211/18 ,  C07D211/52 ,  Y10S514/849

公开(公告)号：US3644520A

公开(公告)日：1972-02-22

申请号：US3644520D

申请日：1968-12-10

申请人： ALLEN & HANBURYS LTD

发明人： HARTLEY DAVID ,  JACK DAVID ,  LUNTS LAWRENCE H C

IPC分类号： C07C275/24 ,  C07C103/38 ,  C07C103/12

CPC分类号： C07C275/24 ,  Y02P20/55

摘要： COMPOUNDS HAVNG THE SKETETAL STRUCTURE

(1-(HO-),2-(>N-CH2-)PHENYL)-CH(OH)-CH(-)-N
AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE DISCLOSED COMPOUNDS POSSESS STIMULANT OR BLOCKING ACTIONS ON ADRENERGIC-RECEPTORS.

公开(公告)号：US3577549A

公开(公告)日：1971-05-04

申请号：US3577549D

申请日：1968-08-09

申请人： ALLEN & HANBURYS LTD

发明人： JACK DAVID ,  RHODES DERYCK

IPC分类号： A61K31/19 ,  A61K27/00

CPC分类号： A61K31/19

摘要： PHARMACEUTICAL COMPOSITIONS COMPRISING AS ACTIVE INGREDIENT EITHER P-BENZOYL-PHENYLACETIC ACID, OR O-BENZOYLPHENYLACETIC ACID, WHICH COMPOUNDS MAY BE USED IN THE FORM OF PHYSIOLOGICALLY ACCEPTABLE SALTS. THESE ACTIVE INGREDIENTS HAVE ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY. THEY MAY BE ADMINISTERED IN DOSAGE UNIT FORM.