公开(公告)号：US12076388B2

公开(公告)日：2024-09-03

申请号：US18165804

申请日：2023-02-07

Applicant: ARAMIS BIOTECHNOLOGIES INC.

Inventor： Pierre-Olivier Lavoie ,  Marc-Andre D'Aoust

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  A61P31/14 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N15/82

CPC classification number: A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/8258 ,  A61K2039/5258 ,  C12N2770/16022 ,  C12N2770/16023 ,  C12N2770/16034

Abstract: Nucleic acids encoding modified norovirus VP1 proteins, and virus-like particles (VLPs) containing one or more of the modified norovirus VP1 proteins, and compositions containing the nucleic acids, VP1 proteins, or the VLPs are provided. Methods for producing modified norovirus VP1 protein, and norovirus VLP, production in plants, portions of the plant or a plant cell, are also provided.

公开(公告)号：US11987601B2

公开(公告)日：2024-05-21

申请号：US17735706

申请日：2022-05-03

Applicant: ARAMIS BIOTECHNOLOGIES INC.

Inventor： Pierre-Olivier Lavoie ,  Marc-Andre D'Aoust

IPC: C07K14/005 ,  A61K39/12 ,  C07K16/10 ,  C12N7/00 ,  C12N15/82 ,  A61K9/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  C07K16/10 ,  C12N7/00 ,  C12N15/8257 ,  A61K9/0019 ,  C07K2319/00 ,  C12N2770/16022 ,  C12N2770/16023 ,  C12N2770/16034

Abstract: Nucleic acids encoding norovirus VP1 fusion proteins and VLPs comprising the norovirus VP1 fusion proteins are provided. Methods for norovirus VP1 fusion protein and norovirus VLP production in plants are also described. The VP1 fusion protein comprises, a first sequence encoding an S domain derived from a first norovirus strain, and a second sequence encoding a P domain derived from a second norovirus strain.