公开(公告)号：US20240350619A1

公开(公告)日：2024-10-24

申请号：US18027132

申请日：2022-05-10

申请人： GUANGZHOU RIBOBIO CO., LTD. ,  ARGORNA PHARMACEUTICALS CO., LTD.

发明人： Bill Biliang ZHANG ,  Lin MA ,  Jian WEN ,  Hong ZHANG ,  Huiling ZHONG

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2830/50

摘要： This disclosure provides vaccines and compositions based on SARS-COV-2 S protein, and specifically relates to recombinant SARS-COV-2 spike protein (Sprotein) and mRNA and DNA coding thereof. This disclosure also relates to recombinant plasmid comprising DNA sequence encoding recombinant S protein. This disclosure further relates to composition comprising the recombinant S protein and/or mRNA mentioned above, mRNA-carrier particle such as lipid nanoparticle (LNP), and composition such as a vaccine composition.