公开(公告)号：US20120230977A1

公开(公告)日：2012-09-13

申请号：US13411324

申请日：2012-03-02

Applicant: Marissa M. Darmoc ,  Lauren S. BROWN ,  Jenny E. RAYNOR ,  Alice CHOU ,  Abigail COHEN

Inventor： Marissa M. Darmoc ,  Lauren S. BROWN ,  Jenny E. RAYNOR ,  Alice CHOU ,  Abigail COHEN

IPC: A61K38/39 ,  C07K1/113 ,  A61P7/04 ,  C07K14/78 ,  A61K38/48

CPC classification number: A61L15/325 ,  A61K9/70 ,  A61K38/39 ,  A61K38/4833 ,  A61L15/00 ,  A61L15/28 ,  A61L15/42 ,  A61L17/00 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L24/102 ,  A61L26/00 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  C07K14/78 ,  C12Y304/21005 ,  A61K2300/00

Abstract: The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.

Abstract translation: 本发明涉及止血组合物和促进止血的方法。 本发明还涉及止血组合物和促进伤口愈合的方法。 在各种实施方案中，止血组合物包含可交联胶原分子，其具有在交联胶原时由胶原固体与重量百分数交联剂的重量百分比的百分比控制的孔隙率。 在其它实施方案中，止血组合物包含可交联的胶原分子，其具有在制备期间干燥组合物时由温度和冷冻速率控制的孔隙率。 在一些实施方案中，组合物含有另外的试剂，包括生物试剂。

公开(公告)号：US09447169B2

公开(公告)日：2016-09-20

申请号：US13411324

申请日：2012-03-02

Applicant: Marissa M. Darmoc ,  Lauren S. Brown ,  Jenny E. Raynor ,  Alice Chou ,  Abigail Cohen

Inventor： Marissa M. Darmoc ,  Lauren S. Brown ,  Jenny E. Raynor ,  Alice Chou ,  Abigail Cohen

IPC: A61K38/46 ,  C07K14/78 ,  A61K38/39 ,  A61K38/48

CPC classification number: A61L15/325 ,  A61K9/70 ,  A61K38/39 ,  A61K38/4833 ,  A61L15/00 ,  A61L15/28 ,  A61L15/42 ,  A61L17/00 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L24/102 ,  A61L26/00 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  C07K14/78 ,  C12Y304/21005 ,  A61K2300/00

Abstract: The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.

Abstract translation: 本发明涉及止血组合物和促进止血的方法。 本发明还涉及止血组合物和促进伤口愈合的方法。 在各种实施方案中，止血组合物包含可交联胶原分子，其具有在交联胶原时由胶原固体与重量百分数交联剂的重量百分比的百分比控制的孔隙率。 在其它实施方案中，止血组合物包含可交联的胶原分子，其具有在制备期间干燥组合物时由温度和冷冻速率控制的孔隙率。 在一些实施方案中，组合物含有另外的试剂，包括生物试剂。