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公开(公告)号：US11992554B2
公开(公告)日：2024-05-28
申请号：US17405866
申请日：2021-08-18
申请人： RXOS Medical Inc.
IPC分类号： A61K9/06 , A61K9/00 , A61K31/13 , A61K31/15 , A61K31/216 , A61K31/445 , A61K33/38 , A61K45/06 , A61K47/32 , A61L15/32 , A61L15/44 , A61L15/60
CPC分类号： A61K9/06 , A61K9/0014 , A61K31/13 , A61K31/15 , A61K31/216 , A61K31/445 , A61K33/38 , A61K45/06 , A61K47/32 , A61L15/325 , A61L15/44 , A61L15/60 , A61K33/38 , A61K2300/00 , A61K31/13 , A61K2300/00 , A61K31/15 , A61K2300/00
摘要： A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.
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公开(公告)号：US20240043500A1
公开(公告)日：2024-02-08
申请号：US18483108
申请日：2023-10-09
申请人： COLZYX AB
发明人： Matthias MÖRGELIN , Suado ABDILLAHI
IPC分类号： C07K14/78 , A61L27/54 , A61L15/44 , C07K14/47 , A61P17/02 , A61P31/04 , A01N47/44 , A61L15/32 , A61L17/00 , A61L17/14 , A61L24/00 , A61L24/10 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/60 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , C07K14/755
CPC分类号： C07K14/78 , A61L27/54 , A61L15/44 , C07K14/4723 , A61P17/02 , A61P31/04 , A01N47/44 , A61L15/32 , A61L15/325 , A61L17/005 , A61L17/145 , A61L24/0015 , A61L24/102 , A61L24/108 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/60 , A61L29/045 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/044 , A61L31/047 , A61L31/10 , A61L31/16 , C07K14/755 , A61L2300/404 , A61K9/7023
摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.
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公开(公告)号：US11877910B2
公开(公告)日：2024-01-23
申请号：US16760984
申请日：2018-11-01
CPC分类号： A61F13/00063 , A61F13/00012 , A61F13/00046 , A61L15/28 , A61L15/325 , A61F2013/00255 , A61L2300/104 , A61L2300/404
摘要： A dressing configured to be positioned adjacent to a tissue site is disclosed herein. The dressing may include oxidized regenerated cellulose (ORC), collagen, and at least one nutrient including glutamine. Methods of treating a tissue site are also disclosed herein.
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公开(公告)号：US11814422B2
公开(公告)日：2023-11-14
申请号：US17474434
申请日：2021-09-14
申请人： COLZYX AB
发明人： Matthias Mörgelin , Suado Abdillahi
IPC分类号： C07K14/78 , A61L27/54 , A61K38/00 , A61L15/44 , C07K14/47 , A61P17/02 , A61P31/04 , A01N47/44 , A61L15/32 , A61L17/00 , A61L17/14 , A61L24/00 , A61L24/10 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/60 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , C07K14/755 , A61K9/70 , A61K9/00
CPC分类号： C07K14/78 , A01N47/44 , A61L15/32 , A61L15/325 , A61L15/44 , A61L17/005 , A61L17/145 , A61L24/0015 , A61L24/102 , A61L24/108 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/54 , A61L27/60 , A61L29/045 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/044 , A61L31/047 , A61L31/10 , A61L31/16 , A61P17/02 , A61P31/04 , C07K14/4723 , C07K14/755 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/7023 , A61K38/00 , A61L2300/252 , A61L2300/404 , A61L2300/606 , A61L2420/00 , A61L2430/34 , C07K2319/00
摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.
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公开(公告)号：US20230302190A1
公开(公告)日：2023-09-28
申请号：US18327311
申请日：2023-06-01
CPC分类号： A61L15/325 , A61L15/225 , A61L15/42
摘要： A two-dimensional material for the medical wound area treatment is disclosed. A non-woven fabric consists of resorbable polymer filaments and collagen particles which have a particle size I >80 μm and are disposed on and/or in the non-woven fabric.
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公开(公告)号：US20190231827A1
公开(公告)日：2019-08-01
申请号：US16342617
申请日：2017-10-18
发明人： Justin J. Baker , Peter H. Gingras
CPC分类号： A61K35/68 , A01N63/00 , A61F13/00063 , A61K9/0014 , A61K9/7007 , A61K47/46 , A61L15/325 , A61P17/02 , A61P31/04
摘要： A method of treating or preventing a microbial infection in a subject is described. The method includes contacting a microorganism within the subject with a composition comprising one or more species of amoebae of the genus Willaertia. Antibiotic wound dressings and kits for providing amoeba for treatment or prevention of microbial infection in a subject are also described.
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公开(公告)号：US20190216972A1
公开(公告)日：2019-07-18
申请号：US16330862
申请日：2017-09-07
申请人： JELLAGEN PTY LTD
发明人： Andrew Mearns SPRAGG
CPC分类号： A61L15/325 , A61L15/40 , A61L15/60 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/52 , A61L2430/02 , A61L2430/06 , A61L2430/16 , A61L2430/32 , C12N5/0068 , C12N2513/00 , C12N2533/54
摘要： The present invention resides in a method for producing jellyfish collagen hydrogels and kits for producing the same. The jellyfish collagen hydrogels can be used in the culture of cells. According to the invention, there is a process for producing jellyfish collagen hydrogels comprising jellyfish collagen fibrils, said process comprising the steps of: mixing a solution of purified jellyfish collagen and an aqueous neutralisation buffer; and incubating the mixture for a sufficient time to enable jellyfish collagen fibrils to form, wherein a cross-linking agent is either added during to mixing step or during or after the incubation of the mixture.
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公开(公告)号：US10052400B2
公开(公告)日：2018-08-21
申请号：US15314741
申请日：2015-06-01
申请人： Sofradim Production
发明人： Amandine Jaillon , Aurelie Serrero
CPC分类号： A61L15/325 , A61L27/24 , A61L27/3683 , A61L27/50 , A61L2400/04
摘要： The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of: —a) preparing an acidic solution of non-antigenic collagenous material, —b) pouring the solution of a) into a mold in order to form a layer, —c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.
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公开(公告)号：US20180169293A1
公开(公告)日：2018-06-21
申请号：US15843003
申请日：2017-12-15
申请人： Nitta Casings Inc.
CPC分类号： A61L15/325 , A61K31/722 , A61L15/18 , A61L15/20 , A61L15/225 , A61L15/28 , A61L15/44 , A61L26/0033 , A61L26/0052 , A61L2300/106 , A61L2300/21 , A61L2300/404 , A61L2430/40 , C08L5/08 , C08L89/06
摘要： A hydrolyzed collagen dough produced from bovine collagen and methods for producing the collagen dough from bovine hides is provided. The collagen dough comprises water, bovine collagen, sodium benzoate and hydrochloric acid. To produce the collagen dough, the corium layer is separated from bovine hides and treated. The collagen dough may be used, for example, in biomedical applications, such as cell technology/tissue engineering, suture materials, or film and sponges for skin grafting. The collagen dough may further comprise chitosan.
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公开(公告)号：US20180161210A1
公开(公告)日：2018-06-14
申请号：US15892211
申请日：2018-02-08
发明人： Arthur C. Coffey
IPC分类号： A61F13/00 , A61M27/00 , A61M1/00 , A61F13/02 , A61F17/00 , A61L15/22 , A61L27/24 , A61L15/58 , A61L15/44 , A61L15/42 , A61L15/40 , A61L15/32
CPC分类号： A61F13/00012 , A61F13/00068 , A61F13/02 , A61F13/0216 , A61F13/022 , A61F13/0226 , A61F13/0253 , A61F17/00 , A61F2013/00174 , A61F2013/00357 , A61F2013/00536 , A61F2013/0054 , A61F2013/00859 , A61F2013/00927 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/58 , A61L27/24 , A61L2300/412 , A61L2430/34 , A61M1/0088 , A61M27/00
摘要： A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to be placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.
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