公开(公告)号：US20180028712A1

公开(公告)日：2018-02-01

申请号：US15549029

申请日：2016-02-07

申请人： ARGAMAN TECHNOLOGIES LTD.

发明人： Mechael KANOVSKY

IPC分类号： A61L15/44 ,  A61K33/38 ,  A61K47/34 ,  A61Q19/08 ,  A61K9/70 ,  A61L15/26 ,  A61L15/28 ,  A61K8/19 ,  A61K33/34 ,  A61K47/38

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/731 ,  A61K8/8152 ,  A61K8/85 ,  A61K8/87 ,  A61K8/88 ,  A61K9/70 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K47/34 ,  A61K47/38 ,  A61K2800/5922 ,  A61K2800/624 ,  A61K2800/651 ,  A61L15/00 ,  A61L15/08 ,  A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L2300/102 ,  A61L2300/104 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

摘要： Provided are materials including cell proliferation properties. The materials may include a polymer having incorporated therein a synergistic combination of at least two metal oxide powders, including a mixed oxidation state oxide of a first metal and a single oxidation state oxide of a second metal. The mixed oxidation state oxide may constitute from about 25% wt. to about 75% wt. of the total weight of the synergistic combination of the at least two metal oxide powders. The powders may be incorporated substantially uniformly within the polymer. The ions of the metal powders may be in ionic contact upon exposure of the material to moisture. Further provided are methods for the preparation of the materials and uses thereof, including in skin regeneration processes and cosmetic applications.

公开(公告)号：US20160346134A1

公开(公告)日：2016-12-01

申请号：US15234624

申请日：2016-08-11

申请人： KCI Licensing, Inc.

发明人： Christopher Brian LOCKE ,  Richard Daniel John COULTHARD ,  Timothy Mark ROBINSON ,  Aldan Marcus TOUT

IPC分类号： A61F13/00 ,  A61L31/06 ,  A61M1/00

CPC分类号： A61F13/00068 ,  A61F13/00 ,  A61F13/00008 ,  A61F13/00017 ,  A61F13/00034 ,  A61F13/00038 ,  A61F13/00042 ,  A61F13/00046 ,  A61F2013/00536 ,  A61L15/00 ,  A61L15/16 ,  A61L31/06 ,  A61M1/00 ,  A61M1/0023 ,  A61M1/0084 ,  A61M1/0088 ,  A61M1/0092 ,  A61M1/34 ,  A61M1/3403

摘要： Systems and apparatuses for administering reduced pressure treatment to a tissue site include a reduced pressure source, a drape having a plurality of projections for contacting the tissue site, and an adhesive connected to at least a portion of the drape for sealing the drape to a portion of a patient's intact epidermis.

摘要翻译： 用于对组织部位进行减压治疗的系统和装置包括减压源，具有用于接触组织部位的多个突起的悬垂布，以及连接至至少一部分悬垂布的粘合剂，用于将悬垂物密封到一部分 的病人的完整表皮。

公开(公告)号：US09447169B2

公开(公告)日：2016-09-20

申请号：US13411324

申请日：2012-03-02

申请人： Marissa M. Darmoc ,  Lauren S. Brown ,  Jenny E. Raynor ,  Alice Chou ,  Abigail Cohen

发明人： Marissa M. Darmoc ,  Lauren S. Brown ,  Jenny E. Raynor ,  Alice Chou ,  Abigail Cohen

IPC分类号： A61K38/46 ,  C07K14/78 ,  A61K38/39 ,  A61K38/48

CPC分类号： A61L15/325 ,  A61K9/70 ,  A61K38/39 ,  A61K38/4833 ,  A61L15/00 ,  A61L15/28 ,  A61L15/42 ,  A61L17/00 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/043 ,  A61L24/102 ,  A61L26/00 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2400/06 ,  C07K14/78 ,  C12Y304/21005 ,  A61K2300/00

摘要： The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents.

摘要翻译： 本发明涉及止血组合物和促进止血的方法。 本发明还涉及止血组合物和促进伤口愈合的方法。 在各种实施方案中，止血组合物包含可交联胶原分子，其具有在交联胶原时由胶原固体与重量百分数交联剂的重量百分比的百分比控制的孔隙率。 在其它实施方案中，止血组合物包含可交联的胶原分子，其具有在制备期间干燥组合物时由温度和冷冻速率控制的孔隙率。 在一些实施方案中，组合物含有另外的试剂，包括生物试剂。

公开(公告)号：US09314527B2

公开(公告)日：2016-04-19

申请号：US14550514

申请日：2014-11-21

申请人： Phosphagenics Limited

发明人： Jeremy Cottrell ,  Giacinto Gaetano ,  Mahmoud El-Tamimy ,  Nicholas Kennedy ,  Paul David Gavin

IPC分类号： A61K9/70 ,  A61K47/30 ,  A61K31/355 ,  A61L15/00 ,  A61K47/24 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

CPC分类号： A61K47/24 ,  A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/355 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61L15/00

摘要： A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.

摘要翻译： 适合用于施用生物活性化合物的透皮递送贴剂的组合物，所述组合物包含生育酚的磷酸酯化合物和聚合物载体。

公开(公告)号：US20150376384A1

公开(公告)日：2015-12-31

申请号：US14664974

申请日：2015-03-23

申请人： The Procter & Gamble Company

发明人： Clarissa MALDONADO

IPC分类号： C08L23/06 ,  C08K3/22 ,  A61L15/22 ,  C08K3/26

CPC分类号： C08L23/06 ,  A61F13/15 ,  A61F13/514 ,  A61F13/51401 ,  A61F13/51456 ,  A61F13/51462 ,  A61F13/51464 ,  A61F13/551 ,  A61L15/00 ,  A61L15/225 ,  A61L15/42 ,  A61L15/54 ,  C08J5/18 ,  C08J2323/04 ,  C08J2423/14 ,  C08K3/22 ,  C08K3/26 ,  C08K2003/2237 ,  C08K2003/265

摘要： A film comprising from about 20 wt. % to about 85 wt. % of a polyolefin component and from about 20 wt. % to about 45 wt. % of a particle component; wherein the film has a basis weight of from about 5 gsm to about 25 gsm; wherein the film is activated and subjected to an engineering strain of greater than about 20%; wherein the film has a predicted sound pressure level over the frequency octave range of 2000 Hz-6300 Hz of less than about 43 dB.

摘要翻译： 包含约20wt。 ％至约85重量％ ％的聚烯烃组分和约20wt。 ％至约45wt。 ％的颗粒成分; 其中所述膜的基重为约5gsm至约25gsm; 其中所述膜被活化并经受大于约20％的工程应变; 其中所述胶片在2000Hz-6300Hz的频率倍频程范围内具有小于约43dB的预测声压级。

公开(公告)号：US08637073B2

公开(公告)日：2014-01-28

申请号：US10566121

申请日：2004-07-26

申请人： Bruce E. Reidenberg ,  Daniel A. Spyker

发明人： Bruce E. Reidenberg ,  Daniel A. Spyker

IPC分类号： A61F13/02

CPC分类号： A61K9/7023 ,  A61K31/485 ,  A61L15/00 ,  B09B2220/14

摘要： Dosage regimens of buprenorphine to treat withdrawal or abstinence syndrome in a drug dependent or opioid tolerant patient who is pregnant are described. The method includes treating withdrawal or abstinence syndrome of the patient by transdermal administration of an amount of buprenorphine effective to reduce withdrawal symptoms. For example, a first buprenorphine-containing transdermal dosage form can be administered for a first dosing period that is no more than about 5 days; a second buprenorphine-containing transdermal dosage form for a second dosing period that is no more than about 5 days, the second dosage form comprising the same or a greater dosage of buprenorphine than the first dosage form; and a third buprenorphine-containing transdermal dosage form for a third dosing period that is at least 2 days, the third dosage form comprising the same or a greater dosage of buprenorphine than the second dosage form.

摘要翻译： 描述了丁丙诺啡在怀孕的药物依赖性或阿片受体患者中治疗戒断或禁欲综合征的剂量方案。 该方法包括通过透皮给药一定量的丁丙诺啡来治疗患者的戒断或禁欲综合征，所述丁丙诺啡有效地减少戒断症状。 例如，可以在不超过约5天的第一给药期间施用第一含丁丙诺啡的透皮剂型， 第二给药期间不超过约5天的第二种含丁丙诺啡的透皮剂型，所述第二剂型包含与第一剂型相同或更高剂量的丁丙诺啡; 和含有至少2天的第三给药期的第三种含丁丙诺啡的透皮剂型，所述第三剂型包含与第二剂型相同或更高剂量的丁丙诺啡。

公开(公告)号：US20130336882A1

公开(公告)日：2013-12-19

申请号：US13966912

申请日：2013-08-14

申请人： Mitsui Chemicals, Inc.

发明人： Noriaki ASADA ,  Shinya Aoki ,  Hiroshi Naruse ,  Shoichi Miyakoshi ,  Masami Arata

IPC分类号： A61L24/04 ,  A61L15/00

CPC分类号： A61L24/043 ,  A61L15/00 ,  A61L15/44 ,  A61L15/58 ,  A61L26/0014 ,  C08L33/06

摘要： The adhesive composition for soft tissues, the adhesive composition for wound dressing or the wound dressing agent composition of the present invention is an adhesive composition for soft tissues, an adhesive composition for wound dressing or a wound dressing agent composition, comprising a monomer (A), a polymer (B) and a polymerization initiator composition (C) containing an organoboron compound, and is characterized by having a viscosity of 0.4 to 75,000 cp within 30 seconds after mixing of the components (A), (B) and (C). The composition of the present invention not only has low toxicity, low harmfulness and high adhesive strength but also is excellent in workability during application and is capable of forming films of excellent properties.

摘要翻译： 本发明的软组织用粘合剂组合物，伤口敷料用粘合剂组合物或伤口敷料剂组合物是软组织用​​粘合剂组合物，伤口敷料用粘合剂组合物或伤口敷料剂组合物，其含有单体（A） ，聚合物（B）和含有有机硼化合物的聚合引发剂组合物（C），其特征在于组分（A），（B）和（C）混合后30秒内的粘度为0.4至75,000cp， 。 本发明的组合物不仅毒性低，危害性低，粘合强度高，而且涂布时的加工性也优异，能够形成优异的膜。

公开(公告)号：US20130330990A1

公开(公告)日：2013-12-12

申请号：US13862779

申请日：2013-04-15

申请人： UNICHARM CORPORATION

发明人： Hideaki ICHIURA ,  Masaaki MORIKAWA ,  Masaki TAKAHASHI ,  Noriyoshi NISHIDA ,  Takamitsu IGAUE ,  Takayoshi Konishi

IPC分类号： B01J20/28 ,  D06M11/00

CPC分类号： B01J20/28038 ,  A61F13/8405 ,  A61L15/00 ,  B05D1/36 ,  B05D3/0254 ,  B05D7/02 ,  D06M11/00 ,  D06M15/13 ,  D06M2101/20 ,  Y10T442/20

摘要： Provided is a method for producing a functional material, including the steps of: bringing a polyvalent metal cation aqueous solution into contact with a base material; bringing a polyanion aqueous solution containing a functional component into contact with the base material previously in contact with the polyvalent metal cation aqueous solution to bond the polyvalent metal cations and the polyanions to each other, and thereby forming an insoluble compound containing the functional component; and drying the base material including the insoluble compound.

摘要翻译： 本发明提供功能材料的制造方法，其特征在于，包括以下工序：使多价金属阳离子水溶液与基材接触; 使含有功能性成分的聚阴离子水溶液与先前与多价金属阳离子水溶液接触的基材接触，使多价金属阳离子和聚阴离子彼此结合，由此形成含有功能成分的不溶性化合物; 并干燥包括不溶性化合物的基材。

公开(公告)号：US20120143114A1

公开(公告)日：2012-06-07

申请号：US13311893

申请日：2011-12-06

申请人： Christopher Brian Locke ,  Richard Daniel John Coulthard ,  Timothy Mark Robinson ,  Aidan Marcus Tout

发明人： Christopher Brian Locke ,  Richard Daniel John Coulthard ,  Timothy Mark Robinson ,  Aidan Marcus Tout

IPC分类号： A61F13/02 ,  A61M1/00 ,  A61F13/00

CPC分类号： A61F13/00068 ,  A61F13/00 ,  A61F13/00008 ,  A61F13/00017 ,  A61F13/00034 ,  A61F13/00038 ,  A61F13/00042 ,  A61F13/00046 ,  A61F2013/00536 ,  A61L15/00 ,  A61L15/16 ,  A61L31/06 ,  A61M1/00 ,  A61M1/0023 ,  A61M1/0084 ,  A61M1/0088 ,  A61M1/0092 ,  A61M1/34 ,  A61M1/3403

摘要： Systems and apparatuses for administering reduced pressure treatment to a tissue site include a reduced pressure source, a drape having a plurality of projections for contacting the tissue site, and an adhesive connected to at least a portion of the drape for sealing the drape to a portion of a patient's intact epidermis.

摘要翻译： 用于对组织部位进行减压治疗的系统和装置包括减压源，具有用于接触组织部位的多个突起的悬垂布，以及连接至至少一部分悬垂布的粘合剂，用于将悬垂物密封到一部分 的病人的完整表皮。

公开(公告)号：US20080254107A1

公开(公告)日：2008-10-16

申请号：US11932933

申请日：2007-10-31

申请人： Danniel Jacques

发明人： Danniel Jacques

IPC分类号： A61K9/70 ,  A61K31/785 ,  A61K31/78 ,  A61K31/715 ,  A61P19/02

CPC分类号： A61L15/16 ,  A61K9/7023 ,  A61K31/715 ,  A61K31/78 ,  A61K31/785 ,  A61L15/00

摘要： The present invention relates to a method for treating a subject for a condition or inflammation associated with oedema, excess body fluids or oedema and excess body fluids, or for treating a subject for an abscess, boil, blister or cyst. The method comprises applying to the skin surface covering a body part or region affected by said condition, inflammation, abscess, boil, blister or cyst a composition capable of transdermally attracting fluids from the body part or region or its proximity, wherein said composition comprises at least one adsorptive or absorptive agent, and leaving said composition in contact with the skin for sufficient time to allow said composition to transdermally absorb or adsorb at least a portion of the body fluids from said body part or region. The present invention also relates to compositions for absorbing or adsorbing fluids from a body part or region, and which are capable of transdermally attracting fluids from body parts or regions or their proximity.

摘要翻译： 本发明涉及一种用于治疗与水肿，多余体液或水肿和多余体液相关的病症或炎症的受试者的方法，或用于治疗受试者脓肿，沸腾，水疱或囊肿的方法。 该方法包括将覆盖受所述病症，炎症，脓肿，沸腾，起泡或囊肿影响的身体部位或区域的皮肤表面施用于能够从身体部位或区域或其邻近经皮吸引流体的组合物，其中所述组合物包含 至少一种吸附剂或吸收剂，并使所述组合物与皮肤接触足够的时间，以允许所述组合物经皮吸收或吸附至少一部分体液从所述身体部位或区域。 本发明还涉及用于从身体部位或区域吸收或吸附流体的组合物，其能够经皮吸引身体部位或区域的流体或其邻近。