公开(公告)号：US20220400951A1

公开(公告)日：2022-12-22

申请号：US17571496

申请日：2022-01-09

申请人： Ablacon Inc.

发明人： Philip Haeusser ,  Peter Ruppersberg ,  Christoph Dinh

IPC分类号： A61B5/00 ,  A61B18/14 ,  A61B5/287 ,  A61B5/316 ,  A61B5/327 ,  A61B5/339 ,  A61B5/341

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to estimate the action potential wave propagation in a patient's heart, and subsequently to detect at least one location or type of at least one source of, or rotational phenomenon associated with, at least one cardiac rhythm disorder using intracardiac electrodes and a modified multi-frame Horn-Schunck algorithm to generate a map corresponding to a spatial map, the map being configured to reveal on a monitor or display to a user the at least one location of the at least one source of the at least one cardiac rhythm disorder.

公开(公告)号：US20190125186A1

公开(公告)日：2019-05-02

申请号：US15923286

申请日：2018-03-16

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B18/14 ,  A61B5/044 ,  A61B5/042

CPC分类号： A61B5/0006 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/04028 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/742 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61B2090/065

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart, such as atrial fibrillation, and to classify same. Velocity vector maps reveal the location of the source of the at least one cardiac rhythm disorder in the patient's heart, which may be, by way of example, an active rotor in the patient's myocardium and atrium. The resulting velocity vector map may be further processed and/or analyzed to classify the nature of the patient's cardiac rhythm disorder, e.g., as Type A, B or C atrial fibrillation. The resulting cardiac rhythm classification then can be used to determine the optimal, most efficacious and/or most economic treatment or surgical procedure that should be provided to the individual patient. A simple and computationally efficient intra-cardiac catheter-based navigation system is also described.

公开(公告)号：US10201277B2

公开(公告)日：2019-02-12

申请号：US15548671

申请日：2016-09-07

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61N5/04 ,  A61B5/00 ,  A61B5/04 ,  A61B5/042 ,  A61B5/044 ,  A61B18/14 ,  A61B5/0402 ,  A61B18/00 ,  A61B90/00

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

公开(公告)号：US10143374B2

公开(公告)日：2018-12-04

申请号：US15258410

申请日：2016-09-07

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/042 ,  A61B5/044 ,  A61B18/14 ,  A61B5/0402 ,  A61B18/00

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

公开(公告)号：US20240206731A1

公开(公告)日：2024-06-27

申请号：US18511832

申请日：2023-11-16

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/00 ,  A61B5/287 ,  A61B5/316 ,  A61B5/327 ,  A61B5/339 ,  A61B5/341 ,  A61B18/00 ,  A61B18/14 ,  A61B90/00

CPC分类号： A61B5/0006 ,  A61B5/287 ,  A61B5/316 ,  A61B5/327 ,  A61B5/339 ,  A61B5/341 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/742 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61B2090/065

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each of selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

公开(公告)号：US20210000369A1

公开(公告)日：2021-01-07

申请号：US16918588

申请日：2020-07-01

申请人： Ablacon Inc.

发明人： David Emanuel Luksic ,  Philip Haeusser ,  Peter Ruppersberg

IPC分类号： A61B5/0468 ,  A61B5/042 ,  A61B5/044 ,  A61B5/00 ,  A61B34/20 ,  A61B5/055 ,  A61B6/03 ,  A61B18/14

摘要： Electrographic flow mapping (EGF mapping) is a technique used for aiding catheter ablation when treating atrial fibrillation. Visualizing EGF fields during a cardiac catherization and ablation procedure is an important and necessary part of conducting the procedure. Several different visualization methods are described and disclosed herein that may be employed to visualize EGF fields and maps, including quiver plots, streamline plots, particle plots, particle trail plots, moving particle plots, and moving and fading particle plots.

公开(公告)号：US10820800B2

公开(公告)日：2020-11-03

申请号：US15923286

申请日：2018-03-16

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/042 ,  A61B5/044 ,  A61B18/14 ,  A61B5/0402 ,  A61B18/00 ,  A61B90/00

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart, such as atrial fibrillation, and to classify same. Velocity vector maps reveal the location of the source of the at least one cardiac rhythm disorder in the patient's heart, which may be, by way of example, an active rotor in the patient's myocardium and atrium. The resulting velocity vector map may be further processed and/or analyzed to classify the nature of the patient's cardiac rhythm disorder, e.g., as Type A, B or C atrial fibrillation. The resulting cardiac rhythm classification then can be used to determine the optimal, most efficacious and/or most economic treatment or surgical procedure that should be provided to the individual patient. A simple and computationally efficient intra-cardiac catheter-based navigation system is also described.

公开(公告)号：US20200245885A1

公开(公告)日：2020-08-06

申请号：US16724254

申请日：2019-12-21

申请人： Ablacon Inc

发明人： Philip Haeusser ,  Peter Ruppersberg

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/0408 ,  A61B5/046 ,  A61B5/0285 ,  A61B5/055

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from a patient's body surface, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map. The resulting velocity vector map maybe employed to classify a patient as one of an A-type patient, a B-type patient, and a C-type patient, and to guide therapy subsequently delivered to the patient. Trained atrial discriminative machine learning models that facilitate the foregoing systems and methods, and that provide predictions or results concerning a patient's condition, are also disclosed.

公开(公告)号：US20180020916A1

公开(公告)日：2018-01-25

申请号：US15548671

申请日：2016-09-07

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/00 ,  A61B5/0402 ,  A61B5/04

CPC分类号： A61B5/0006 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/04028 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/742 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61B2090/065

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

公开(公告)号：US20170065198A1

公开(公告)日：2017-03-09

申请号：US15258410

申请日：2016-09-07

申请人： Ablacon Inc.

发明人： Peter Ruppersberg

IPC分类号： A61B5/04 ,  A61B18/14 ,  A61B5/0452 ,  A61B5/044 ,  A61B5/042 ,  A61B5/00

CPC分类号： A61B5/0006 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/04028 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/742 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61B2090/065

摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

摘要翻译： 公开了被配置为检测患者心脏中的至少一种心律失常的源的位置的系统，装置，组件和方法的各种示例和实施例。 在一些实施例中，从患者心脏内部获取电描记图信号，随后进行归一化，调整和/或滤波，随后生成电极位置的二维空间图，网格或表示，处理幅度调整和滤波电描记图 信号以产生至少部分地对应于2D地图的多个三维电描绘表面，为每个或选择的离散时间生成一个表面，并且经过时间处理多个三维电描记图表面以生成相应的速度矢量图 至少部分地涉及2D地图。 所得到的速度矢量图被配置为显示所述至少一种心律失常的来源的位置，其可以例如是患者心肌和心房中的活动转子。