公开(公告)号：US20120009242A1

公开(公告)日：2012-01-12

申请号：US13127152

申请日：2009-11-03

申请人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

发明人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

IPC分类号： A61K31/785 ,  A61L15/24 ,  A61P7/04 ,  A61L15/44 ,  A61L31/12 ,  A61L31/16 ,  C08F226/02 ,  A61L15/58

CPC分类号： A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2300/43 ,  C08L33/26

摘要： The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.

摘要翻译： 本申请被描述为合成的聚合物水凝胶基材料，其能够主动地诱导身体在血液或无细胞血浆中的天然止血凝血过程。 本发明提供了能够诱导凝血并递送用于止血或伤口护理应用的治疗剂的含伯胺聚合物水凝胶的开发，以及形成能够诱导凝血过程的含伯胺聚合物水凝胶的方法。 含伯胺聚合物水凝胶能够实现与生物基止血剂相同的最终结果，没有疾病传播或免疫应答的先天风险，并且价格仅为一小部分。 此外，由于其固有的基于水凝胶的设计，该材料具有阻止失血的能力，同时以受控的方式递送治疗剂，这可能彻底改变了治疗伤口的方式。