公开(公告)号：US08128679B2

公开(公告)日：2012-03-06

申请号：US11973707

申请日：2007-10-09

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/06 ,  A61F2/88

CPC分类号： A61F2/89 ,  A61F2/86 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0069 ,  A61F2250/0031

摘要： Disclosed is a stent with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the stent. The stent may include an essentially tubular body formed by a web structure that is composed of a plurality of longitudinally adjacent web rings, each including a plurality of web elements that are disposed circumferentially around the longitudinal axis of the stent and that are adjoined one to the other by a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring by a connector having a step-wise configuration, in which a central segment of the connector is disposed essentially parallel to the longitudinal axis of the stent and may become twisted to absorb torque imposed on the stent.

摘要翻译： 公开了具有高度柔性结构的支架，其被配置为提供升高的血管支架程度并且吸收施加在支架上的扭矩。 支架可以包括由腹板结构形成的基本上管状的主体，腹板结构由多个纵向相邻的腹板环组成，每个腹板环包括围绕支架的纵向轴线周向设置的多个腹板元件， 另一个由一个连接弯。 第一腹板环中的每个接头弯曲部通过具有逐步构造的连接器联接到相邻环中的另一接合弯曲部，其中连接器的中心部分基本上平行于支架的纵向轴线设置，并且可以变为 扭转以吸收施加在支架上的扭矩。

公开(公告)号：US20120165921A1

公开(公告)日：2012-06-28

申请号：US13411135

申请日：2012-03-02

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/82

CPC分类号： A61F2/89 ,  A61F2/86 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0069 ,  A61F2250/0031

摘要： The present invention concerns a stent with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the stent. In one embodiment, the stent of the present invention includes an essentially tubular body formed by a web structure that is composed of a plurality of longitudinally adjacent web rings, each including a plurality of web elements that are disposed circumferentially around the longitudinal axis of the stent and that are adjoined one to the other by a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring by a connector having a step-wise configuration, in which a central segment of the connector is disposed essentially parallel to the longitudinal axis of the stent and may become twisted to absorb torque imposed on the stent.

摘要翻译： 本发明涉及一种具有高柔性结构的支架，其被配置为提供升高的血管构架并吸收施加在支架上的扭矩。 在一个实施例中，本发明的支架包括由腹板结构形成的基本上管状的主体，该腹板结构由多个纵向相邻的腹板环组成，每个腹板环包括围绕支架的纵向轴线周向设置的多个腹板元件 并且通过连接弯曲部彼此相邻。 第一腹板环中的每个接头弯曲部通过具有逐步构造的连接器联接到相邻环中的另一接合弯曲部，其中连接器的中心部分基本上平行于支架的纵向轴线设置，并且可以变为 扭转以吸收施加在支架上的扭矩。

公开(公告)号：US20080294240A1

公开(公告)日：2008-11-27

申请号：US11973707

申请日：2007-10-09

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/06

CPC分类号： A61F2/89 ,  A61F2/86 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0069 ,  A61F2250/0031

摘要： The present invention concerns a stent with a highly flexible structure that is configured to provide an elevated degree of vessel scaffolding and to absorb torque applied on the stent. In one embodiment, the stent of the present invention includes an essentially tubular body formed by a web structure that is composed of a plurality of longitudinally adjacent web rings, each including a plurality of web elements that are disposed circumferentially around the longitudinal axis of the stent and that are adjoined one to the other by a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring by a connector having a step-wise configuration, in which a central segment of the connector is disposed essentially parallel to the longitudinal axis of the stent and may become twisted to absorb torque imposed on the stent.

摘要翻译： 本发明涉及一种具有高柔性结构的支架，其被配置为提供升高的血管构架并吸收施加在支架上的扭矩。 在一个实施例中，本发明的支架包括由腹板结构形成的基本上管状的主体，该腹板结构由多个纵向相邻的腹板环组成，每个腹板环包括围绕支架的纵向轴线周向设置的多个腹板元件 并且通过连接弯曲部彼此相邻。 第一腹板环中的每个接头弯曲部通过具有逐步构造的连接器联接到相邻环中的另一接合弯曲部，其中连接器的中心部分基本上平行于支架的纵向轴线设置，并且可以变为 扭转以吸收施加在支架上的扭矩。

公开(公告)号：US08016874B2

公开(公告)日：2011-09-13

申请号：US11805584

申请日：2007-05-23

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0031

摘要： A stent is disclosed that generates an elevated degree of scaffolding to a bodily vessel while retaining a highly flexible structure. In one embodiment, a stent includes an essentially tubular body formed by a web structure that is configured to expand from a contracted delivery configuration to an expanded deployed configuration and that is composed of a plurality of longitudinally adjacent web rings. Those web rings are formed by a plurality of web elements disposed circumferentially around the longitudinal axis of the stent and adjoined one to the other with a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring with as-shaped connector, and the coupled junction bends are not longitudinally aligned but are instead laterally offset.

摘要翻译： 公开了一种支架，其在保持高柔性结构的同时产生高度的脚手架至身体血管。 在一个实施例中，支架包括由腹板结构形成的基本上管状的主体，所述腹板结构构造成从收缩的输送构型扩展到扩张的展开构型，并且由多个纵向相邻的腹板环组成。 这些腹板环由多个网状元件形成，该多个腹板元件围绕支架的纵向轴线周向设置，并且以连接弯曲部彼此相邻。 第一腹板环中的每个接头弯曲部都与相邻的环中的另一个接合弯曲部分连接成为一个形状的连接器，并且耦合的连接弯曲部不是纵向对齐的，而是侧向偏移。

公开(公告)号：US09320627B2

公开(公告)日：2016-04-26

申请号：US13411135

申请日：2012-03-02

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/915

CPC分类号： A61F2/89 ,  A61F2/86 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0069 ,  A61F2250/0031

摘要： A stent includes an essentially tubular body formed by a web structure that is composed of a plurality of longitudinally adjacent web rings, each including a plurality of web elements that are disposed circumferentially around the longitudinal axis of the stent and that are adjoined one to the other by a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring by a connector having a step-wise configuration, in which a central segment of the connector is disposed essentially parallel to the longitudinal axis of the stent and may become twisted to absorb torque imposed on the stent.

摘要翻译： 支架包括由腹板结构形成的基本上管状的主体，该腹板结构由多个纵向相邻的腹板环组成，每个腹板环包括围绕支架的纵向轴线周向设置并且彼此相邻的多个腹板元件 通过连接弯。 第一腹板环中的每个接头弯曲部通过具有逐步构造的连接器联接到相邻环中的另一接合弯曲部，其中连接器的中心部分基本上平行于支架的纵向轴线设置，并且可以变为 扭转以吸收施加在支架上的扭矩。

公开(公告)号：US20120009242A1

公开(公告)日：2012-01-12

申请号：US13127152

申请日：2009-11-03

申请人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

发明人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

IPC分类号： A61K31/785 ,  A61L15/24 ,  A61P7/04 ,  A61L15/44 ,  A61L31/12 ,  A61L31/16 ,  C08F226/02 ,  A61L15/58

CPC分类号： A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2300/43 ,  C08L33/26

摘要： The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.

摘要翻译： 本申请被描述为合成的聚合物水凝胶基材料，其能够主动地诱导身体在血液或无细胞血浆中的天然止血凝血过程。 本发明提供了能够诱导凝血并递送用于止血或伤口护理应用的治疗剂的含伯胺聚合物水凝胶的开发，以及形成能够诱导凝血过程的含伯胺聚合物水凝胶的方法。 含伯胺聚合物水凝胶能够实现与生物基止血剂相同的最终结果，没有疾病传播或免疫应答的先天风险，并且价格仅为一小部分。 此外，由于其固有的基于水凝胶的设计，该材料具有阻止失血的能力，同时以受控的方式递送治疗剂，这可能彻底改变了治疗伤口的方式。

公开(公告)号：US20080294239A1

公开(公告)日：2008-11-27

申请号：US11805584

申请日：2007-05-23

申请人： Brendan J. Casey

发明人： Brendan J. Casey

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0031

摘要： The present invention concerns a stent that generates an elevated degree of scaffolding to a bodily vessel while retaining a highly flexible structure. In one embodiment, a stent according to the present invention includes an essentially tubular body formed by a web structure that is configured to expand from a contracted delivery configuration to an expanded deployed configuration and that is composed of a plurality of longitudinally adjacent web rings. Those web rings are formed by a plurality of web elements disposed circumferentially around the longitudinal axis of the stent and adjoined one to the other with a junction bend. Each junction bend in a first web ring is coupled to another junction bend in a neighboring ring with a S-shaped connector, and the coupled junction bends are not longitudinally aligned but are instead laterally offset.

摘要翻译： 本发明涉及一种支架，其能够在保持高柔性结构的同时产生升高的脚手架体积。 在一个实施例中，根据本发明的支架包括由腹板结构形成的基本上管状的主体，所述腹板结构被构造成从收缩的输送构型扩展到扩张的展开构型，并且由多个纵向相邻的腹板环组成。 这些腹板环由多个网状元件形成，该多个腹板元件围绕支架的纵向轴线周向设置，并且以连接弯曲部彼此相邻。 第一腹板环中的每个接头弯曲部都与S形连接器的相邻环中的另一接合弯曲部连接，并且耦合的连接弯曲部不是纵向对齐的，而是横向偏移。