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公开(公告)号：US08586034B2
公开(公告)日：2013-11-19
申请号：US12369650
申请日：2009-02-11
申请人： Teresa Compton , Adam Lloyd Feire
发明人： Teresa Compton , Adam Lloyd Feire
IPC分类号： A61K39/395 , A61K39/00 , A61K39/42 , A61K39/12 , A61K39/35
CPC分类号： C12N7/00 , A61K38/1703 , A61K39/12 , A61K39/245 , C07K14/005 , C07K16/088 , C07K16/2842 , C07K16/2848 , C07K2317/76 , C12N2710/16122 , C12N2710/16134
摘要： The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
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公开(公告)号：US20190002533A1
公开(公告)日：2019-01-03
申请号：US15758491
申请日：2016-09-08
申请人： Johanna ABEND , Zorica DRAGIC , Adam Lloyd FEIRE , Mark KNAPP , Steven KOVACS , Elisabetta TRAGGIAI , Lichun WANG , Yongqiang WANG , Danqing WU , Qilong WU , Fangmin XU
发明人： Johanna ABEND , Zorica DRAGIC , Adam Lloyd FEIRE , Mark KNAPP , Steven KOVACS , Elisabetta TRAGGIAI , Lichun WANG , Yongqiang WANG , Danqing WU , Qilong WU , Fangmin XU
摘要： The present disclosure is directed to anti-VP1 antibodies, antibody fragments, and their uses for the reducing the likelihood or treatment of polyoma virus infection.
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公开(公告)号：US20110117109A1
公开(公告)日：2011-05-19
申请号：US12369650
申请日：2009-02-11
申请人： TERESA COMPTON , ADAM LLOYD FEIRE
发明人： TERESA COMPTON , ADAM LLOYD FEIRE
CPC分类号： C12N7/00 , A61K38/1703 , A61K39/12 , A61K39/245 , C07K14/005 , C07K16/088 , C07K16/2842 , C07K16/2848 , C07K2317/76 , C12N2710/16122 , C12N2710/16134
摘要： The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
摘要翻译： 本发明涉及用于抑制诸如疱疹病毒的病毒进入宿主细胞的方法和组合物。 已经鉴定了保守的病毒整联蛋白结合gB解整合素样结构域，其与整合素结合并促进病毒内化到宿主细胞中。 因此，描述了包括保守的gB解骨素素结构域的抗病毒剂及其抗体的方法和组合物。 这些活性剂干扰病毒粒子与细胞整合素之间的相互作用，从而抑制宿主细胞的病毒感染。
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公开(公告)号：US07491490B2
公开(公告)日：2009-02-17
申请号：US11127601
申请日：2005-05-12
申请人： Teresa Compton , Adam Lloyd Feire
发明人： Teresa Compton , Adam Lloyd Feire
IPC分类号： C12Q1/70
CPC分类号： C12N7/00 , A61K38/1703 , A61K39/12 , A61K39/245 , C07K14/005 , C07K16/088 , C07K16/2842 , C07K16/2848 , C07K2317/76 , C12N2710/16122 , C12N2710/16134
摘要： The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
摘要翻译： 本发明涉及用于抑制诸如疱疹病毒的病毒进入宿主细胞的方法和组合物。 已经鉴定了保守的病毒整联蛋白结合gB解整合素样结构域，其与整合素结合并促进病毒内化到宿主细胞中。 因此，描述了包括保守的gB解骨素素结构域的抗病毒剂及其抗体的方法和组合物。 这些活性剂干扰病毒粒子与细胞整合素之间的相互作用，从而抑制宿主细胞的病毒感染。
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公开(公告)号：US09862760B2
公开(公告)日：2018-01-09
申请号：US15258925
申请日：2016-09-07
申请人： Johanna Abend , Zorica Dragic , Adam Lloyd Feire , Mark Knapp , Steven Kovacs , Elisabetta Traggiai , Lichun Wang , Yongqiang Wang , Danqing Wu , Qilong Wu , Fangmin Xu
发明人： Johanna Abend , Zorica Dragic , Adam Lloyd Feire , Mark Knapp , Steven Kovacs , Elisabetta Traggiai , Lichun Wang , Yongqiang Wang , Danqing Wu , Qilong Wu , Fangmin Xu
CPC分类号： C07K16/084 , A61K39/42 , A61K45/06 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
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公开(公告)号：US20170088605A1
公开(公告)日：2017-03-30
申请号：US15258925
申请日：2016-09-07
申请人： Johanna ABEND , Zorica DRAGIC , Adam Lloyd FEIRE , Mark KNAPP , Steven KOVACS , Elisabetta TRAGGIAI , Lichun WANG , Yongqiang WANG , Danqing WU , Qilong WU , Fangmin XU
发明人： Johanna ABEND , Zorica DRAGIC , Adam Lloyd FEIRE , Mark KNAPP , Steven KOVACS , Elisabetta TRAGGIAI , Lichun WANG , Yongqiang WANG , Danqing WU , Qilong WU , Fangmin XU
CPC分类号： C07K16/084 , A61K39/42 , A61K45/06 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
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