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公开(公告)号：US08758298B2
公开(公告)日：2014-06-24
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列施用于哺乳动物的施用器。 特别是，一种用于将微针装置施加到皮肤表面上的应用装置，包括具有附接到微针装置的凸起中心区域的柔性片材和位于柔性片材的周边处或附近的支撑构件，其中柔性片材被配置为 它将在与片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US20080102192A1
公开(公告)日：2008-05-01
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译： 一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。
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公开(公告)号：US5373929A
公开(公告)日：1994-12-20
申请号：US104053
申请日：1993-09-24
CPC分类号： G07F1/044
摘要： A coin validator is provided in the region of its entrance hopper with a flap which is caused to pivot against the action of a spring when a coin is inserted in the hopper. In the case of fraudulent use of the coin validator wherein a thread is attached to a coin, the movement of the flap into the closed position following passage of the coin causes a tension to be applied in the trailing thread, and the thread under tension is then sensed by a lever mechanism. Actuation of the lever mechanism by the tensioned thread inhibits validation of the attached coin, e.g. by causing any credit added by the passage of the coin past a testing station to be debited before returning the coin to the user.
摘要翻译： PCT No.PCT / GB92 / 00263 Sec。 371日期：1993年9月24日 102（e）日期1993年9月24日PCT提交1992年2月13日PCT公布。 公开号WO92 / 15075 日期为1992年9月3日。在其入口料斗的区域中设有硬币验证器，当将硬币插入料斗时，该挡板使弹簧抵抗弹簧的作用而枢转。 在使用硬币验证器的情况下，其中螺纹被附接到硬币上，在通过硬币之后，翼片移动到关闭位置，导致在后退线中施加张力，并且张力下的线是 然后由杠杆机构感测。 通过张紧螺纹对杠杆机构的致动，禁止附着的硬币的确认。 通过在将硬币通过测试站之前，将硬币通过附加的任何信用借记，然后将硬币返还给用户。
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公开(公告)号：US4625851A
公开(公告)日：1986-12-02
申请号：US636015
申请日：1984-07-30
摘要： A coin testing apparatus subjects a coin inserted into a coin entry (1) and rolling down an inclined track (2) to testing at a testing station (3) comprising sensors (4,5,6) which may for example be inductive sensors. If a coin is found to be acceptable an accept signal is generated and this causes gate mechanism (8) to open to permit the coin to access accept path (9), the gate mechanism (8) being normally closed so that unacceptable coins can only access a reject path (10). A post-gate detector (11) in the accept path (9) senses the passage of an accepted coin and serves to close the gate mechanism (8) and also to determine allocation of a customer credit. A pre-gate detector (12) upstream of the gate mechanism (8) has its output logically processed with the accept signal produced when an acceptable coin is tested and/or with the output of the post-gate detector (11).
摘要翻译： 硬币测试装置使插入到硬币入口（1）中的硬币和向下滚动倾斜轨道（2）的硬币进行测试，以在包括例如感应传感器的传感器（4,5,6）的测试站（3）进行测试。 如果发现硬币是可接受的，则产生接收信号，并且这导致门机构（8）打开以允许硬币进入接受路径（9），门机构（8）通常是关闭的，使得不可接受的硬币只能 访问拒绝路径（10）。 接受路径（9）中的门后检测器（11）感测到接受的硬币的通过并用于关闭门机构（8）并且还确定客户信用的分配。 在栅极机构（8）上游的门前检测器（12）的输出具有逻辑处理，当可接受的硬币被测试时和/或与门极检测器（11）的输出之间产生的接受信号。
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公开(公告)号：US20130123707A1
公开(公告)日：2013-05-16
申请号：US13699805
申请日：2011-05-26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015
摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s−1 and a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.
摘要翻译： 包含至少一种活性药物成分的水性制剂; 和至少一种赋形剂，其中当在100s -1的剪切速率和25℃的温度下测量时，所述水性制剂具有500至30,000厘泊的粘度。 当在环境条件下测量时，表面张力不大于60达因/厘米; 或在环境条件下测量时，医疗级聚合物材料的接触角为50°或更大。 本文还公开了使用水性制剂的包衣和包衣微针阵列的方法。
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6.发明授权C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability 有权C-17/21 OH 20-酮类溶液气溶胶产品具有增强的化学稳定性公开(公告)号：US06315985B1
公开(公告)日：2001-11-13
申请号：US09592885
申请日：2000-06-13
申请人： Zheng Z. Wu , Nayna Govind , Peter R. Johnson
发明人： Zheng Z. Wu , Nayna Govind , Peter R. Johnson
IPC分类号： A61K912
摘要： A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.
摘要翻译： 具有增强化学稳定性的药用气溶胶类固醇溶液制剂产品。 类固醇是在C-17或C-21位置具有OH基团的20-酮类固醇，并且气溶胶容器具有非金属内表面，已被发现可减少这类类固醇的化学降解。
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7.发明授权Apparatus and method for obtaining inconspicuous user input on a mobile device 有权用于在移动设备上获得不显眼的用户输入的装置和方法公开(公告)号：US09185536B1
公开(公告)日：2015-11-10
申请号：US13621659
申请日：2012-09-17
IPC分类号： H04W4/22
摘要： Mobile device, method for operating the same, and associated computer-readable instructions on a non-transitory medium for obtaining inconspicuous user input on a mobile device. The mobile device automatically detects whether an accessory port is engaged with an accessory, such as a headset, for example. In response to at least one change in an indication of the detection, the device automatically performs a sequence of operations. According to one particular embodiment, alarm sequence of operations can include a transmission of an alarm notification to a predefined recipient, for example.
摘要翻译： 移动设备，其操作方法以及在非暂时介质上的相关联的计算机可读指令，用于在移动设备上获得不显眼的用户输入。 移动设备自动检测附件端口是否与附件（例如耳机）接合。 响应于检测指示中的至少一个改变，设备自动执行一系列操作。 根据一个特定实施例，例如，报警操作序列可以包括向预定接收者发送警报通知。
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8.发明授权Coatable compositions, coatings derived therefrom and microarrays having such coatings 有权可涂覆组合物，由其衍生的涂层和具有这种涂层的微阵列公开(公告)号：US08900180B2
公开(公告)日：2014-12-02
申请号：US12092733
申请日：2006-11-17
CPC分类号： A61K9/0021 , A61K47/12 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
摘要翻译： 描述了可涂覆组合物和衍生自可涂覆组合物的涂层，以及包含这种涂层的微阵列。 一方面，本发明提供了一种微阵列，包括：多个从支撑基板延伸的微针; 沉积在所述多个微针中的至少一个上的涂层，所述涂层包含活性剂和生物盐。 另一方面，本发明提供一种可涂覆组合物，其包含：活性剂; 生物盐; 和溶剂。 另一方面，本发明提供涂覆在微针上的干燥涂层，所述涂层包含：活性剂; 和生物盐。
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公开(公告)号：US20130006219A1
公开(公告)日：2013-01-03
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 一种用于将微针阵列施加到哺乳动物的施加器特别地，用于将微针装置施加到皮肤表面的施加装置包括具有附接到微针装置的凸起中心区域的柔性片和位于 柔性片，其中柔性片被构造成使得其将在与片的主平面正交的方向上进行逐步运动。
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公开(公告)号：US08267889B2
公开(公告)日：2012-09-18
申请号：US11718465
申请日：2005-11-18
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，包括具有附接到微针装置的凸起中心区域（115）的柔性片（110）和位于柔性片 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。
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