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公开(公告)号：US08900194B2
公开(公告)日：2014-12-02
申请号：US10621620
申请日：2003-07-17
申请人： Graham M. Clarke , Michael D. Delmore , Michael K. Domroese , Richard H. Ferber , Jay D. Jacobs , Jamieson C. Keister , Franklyn L. Frederickson
发明人： Graham M. Clarke , Michael D. Delmore , Michael K. Domroese , Richard H. Ferber , Jay D. Jacobs , Jamieson C. Keister , Franklyn L. Frederickson
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/7023 , A61M2037/0023 , A61M2037/0046 , A61M2205/0244
摘要： Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.
摘要翻译： 公开了具有截头锥形形状的具有微针的微针装置。 微针装置的微针也可以具有受控的纵横比。 公开了一种微针输送装置，其包括设计成以可以增强角质层穿孔的速度递送微针的驱动器，同时限制在输送部位经历的疼痛的感觉。
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公开(公告)号：US08758298B2
公开(公告)日：2014-06-24
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列施用于哺乳动物的施用器。 特别是，一种用于将微针装置施加到皮肤表面上的应用装置，包括具有附接到微针装置的凸起中心区域的柔性片材和位于柔性片材的周边处或附近的支撑构件，其中柔性片材被配置为 它将在与片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US20080039805A1
公开(公告)日：2008-02-14
申请号：US11569982
申请日：2005-06-09
申请人： Franklyn L. Frederickson , Chad J. Carter , Kanta Kumar , Michael A. Semonick , David J. Wirtanen
发明人： Franklyn L. Frederickson , Chad J. Carter , Kanta Kumar , Michael A. Semonick , David J. Wirtanen
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023
摘要： A patch application device wherein the patch is retained in position within the collar until delivery through contact of at least one obstruction inside the collar with a portion of an adhesive on the front surface (e.g., microneedle-containing surface) of the patch. The collar and patch can be used to form separate replaceable cartridges, and the combination can be provided as a kit.
摘要翻译： 一种补片施加装置，其中补片保持在套环内的适当位置，直到通过套环内的至少一个障碍物与贴片前表面（例如，包含微针的表面）上的粘合剂的一部分接触而递送。 套环和贴片可以用于形成单独的可替换的盒，并且组合可以作为套件提供。
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公开(公告)号：US09119945B2
公开(公告)日：2015-09-01
申请号：US12296590
申请日：2007-04-20
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A device (100) for applying a microneedle array to a skin surface. The device comprises a base (120) defining a skin contacting plane, an array component having a skin facing side comprising a microneedle array, and at least one connecting member (140) having a first portion affixed through a first hinge (142) to the base and a second portion affixed to the array component. The connecting member has a first equilibrium position with the microneedle array in a recessed position within the device and a second equilibrium position with the microneedle array positioned so as to be able to contact a skin surface.
摘要翻译： 一种用于将微针阵列施加到皮肤表面的装置（100）。 该装置包括限定皮肤接触平面的基部（120），具有面向皮肤的侧面的阵列部件，其包括微针阵列，以及至少一个连接部件（140），第一部分通过第一铰链（142）固定到 基部和固定到阵列部件的第二部分。 连接构件具有第一平衡位置，其中微针阵列处于装置内的凹陷位置，并且第二平衡位置与微针阵列定位成能够接触皮肤表面。
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公开(公告)号：US08784363B2
公开(公告)日：2014-07-22
申请号：US11993137
申请日：2006-06-23
IPC分类号： A61B17/20
CPC分类号： A61M5/158 , A61B17/205 , A61M37/0015 , A61M2005/1585 , A61M2037/0023
摘要： An applicator device (20) including a housing (22), an impactor (62) for impacting a microneedle array and accelerating the microneedle array toward the target site, wherein the impactor is capable of moving along an arcuate path to move the microneedle array toward the target site. Also, an applicator device including a housing, a patch applicator pivotally supported by the housing, and a torsion spring. The patch applicator has a retaining portion (40) and a patch contacting portion (70), and the patch contacting portion is capable of moving along a substantially arcuate path between a first position and a second position. The torsion spring is capable of biasing the patch applicator relative to the housing.
摘要翻译： 一种涂抹器装置（20），包括壳体（22），用于冲击微针阵列并将微针阵列加速朝向目标部位的冲击器（62），其中冲击器能够沿着弓形路径移动以将微针阵列朝向 目标网站。 而且，包括壳体，由壳体可枢转地支撑的贴片施加器和扭转弹簧的施加器装置。 贴片施加器具有保持部分（40）和贴片接触部分（70），并且贴片接触部分能够沿第一位置和第二位置之间的大致弧形路径移动。 扭转弹簧能够相对于壳体偏置贴片施加器。
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公开(公告)号：US20100193997A1
公开(公告)日：2010-08-05
申请号：US11916468
申请日：2006-06-08
CPC分类号： B81C99/009 , B29C33/00 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111
摘要： The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.
摘要翻译： 本发明涉及一种形成用于制造具有多个微喷射体的模制品的模具的方法。 另外，本发明提供了形成具有多个微喷射体的成型品的方法。 一方面，提供了模具工件，具有具有对应于微喷射体的形状的尖端的工具，其中刀具的硬度大于模具工件的硬度，被压入模具工件并移除，从而形成 具有适合用于制造模制品的微型喷射腔的模具。
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公开(公告)号：US10035008B2
公开(公告)日：2018-07-31
申请号：US11910173
申请日：2006-04-07
CPC分类号： A61M37/0015 , A61B5/14514 , A61M2037/0023
摘要： A microneedle application device for moving a microneedle array toward a target skin location includes a feedback sensor. The feedback sensor is operably connected to the microneedle application device, and is capable of generating an output corresponding to forces between the target skin location and the microneedle application device.
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公开(公告)号：US09174035B2
公开(公告)日：2015-11-03
申请号：US11718461
申请日：2005-11-18
CPC分类号： A61M37/0015 , A61M2025/0253 , A61M2025/026 , A61M2037/0023
摘要： An applicator that has an elastic band to snap a microneedle array against skin with a predetermined force and velocity. The microneedle array, which may be pre-loaded with drug(s), is attached to the elastic band such that the band can be secured in place (e.g., wrapped around a person's arm), pulled away from the arm, and released from a suitable distance so that the microneedle array snaps back against the arm with sufficient force to cause an intended amount of penetration of microneedles. Also, a microneedle application device has an elastic band, a microneedle device, and a structure attaching the band to the microneedle device.
摘要翻译： 具有弹性带的敷贴器，以预定的力和速度将微针阵列卡扣在皮肤上。 可以预先装载药物的微针阵列附接到弹性带，使得带可以固定在适当位置（例如，缠绕在人的手臂上），从臂拉出并从臂释放 合适的距离，使得微针阵列以足够的力以相对于手臂的方式回弹以产生预期的微针穿透量。 此外，微针施加装置具有弹性带，微针装置和将带附着到微针装置的结构。
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公开(公告)号：US20080114298A1
公开(公告)日：2008-05-15
申请号：US11718465
申请日：2005-11-18
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，包括具有附接到微针装置的凸起中心区域（115）的柔性片（110）和位于柔性片 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。
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公开(公告)号：US20130006219A1
公开(公告)日：2013-01-03
申请号：US13611942
申请日：2012-09-12
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： An applicator used to apply microneedle arrays to a mammal In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.
摘要翻译： 一种用于将微针阵列施加到哺乳动物的施加器特别地，用于将微针装置施加到皮肤表面的施加装置包括具有附接到微针装置的凸起中心区域的柔性片和位于 柔性片，其中柔性片被构造成使得其将在与片的主平面正交的方向上进行逐步运动。
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