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    Methods for regulating transcription by targeting quadruplex DNA
    2.
    发明授权
    Methods for regulating transcription by targeting quadruplex DNA 失效
    通过靶向四联体DNA调节转录的方法

    公开(公告)号：US07405041B2

    公开(公告)日：2008-07-29

    申请号：US10645471

    申请日：2003-08-20

    申请人： Scot W. Ebbinghaus ,  Laurence H. Hurley ,  Adam Siddiqui-Jain ,  Regan Memmott

    发明人： Scot W. Ebbinghaus ,  Laurence H. Hurley ,  Adam Siddiqui-Jain ,  Regan Memmott

    IPC分类号： C12Q1/68

    CPC分类号： C07D513/22 ,  Y10S977/924

    摘要： Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that the nucleotide sequences (GGA)4 (SEQ ID NO: 1) and (GGA)3GG (SEQ ID NO: 2) form biologically significant quadruplex structures. Thus, provided herein are methods for identifying molecules that modulate the biological activity of quadruplex DNA comprising the nucleotide sequence (GGA)4 (SEQ ID NO: 1) or the nucleotide sequence (GGA)3GG (SEQ ID NO: 2), and specifically, methods for identifying molecules that bind such quadruplexes. Also provided herein are methods for modulating the biological activity of a biologically significant native quadruplex DNA with a molecule identified by the methods described herein.

    摘要翻译： 在双链DNA可能产生的不同的intrastrand四链体结构中，已经发现核苷酸序列（GGA）4（SEQ ID NO：1）和（GGA）3

    MCL-1 quadruplex nucleic acids and uses thereof
    4.
    发明申请
    MCL-1 quadruplex nucleic acids and uses thereof 审中-公开
    MCL-1四核苷酸及其用途

    公开(公告)号：US20060286575A1

    公开(公告)日：2006-12-21

    申请号：US11404552

    申请日：2006-04-14

    申请人： Thomas Farrell ,  Adam Siddiqui-Jain

    发明人： Thomas Farrell ,  Adam Siddiqui-Jain

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer diagnostics and prognostics to prevent and/or treat cancer, nucleic acid therapeutics that target altered MCL-1 nucleotide sequences and related methods, methods for identifying compounds that modulate the biological activity of a native MCL-1 quadruplex DNA, and methods for modulating the biological activity of a native MCL-1 quadruplex DNA with a compound identified by the methods described herein. Also provided are methods of selecting a subject for treatment of a cell-proliferative disorder with a quadruplex-interacting molecule.

    摘要翻译： 已经发现了MCL-1调节区的生物学显着的四重结构。 四连体形成核苷酸序列中的某些突变改变了四重结构，并与癌症和其他疾病有关。 因此，本文提供了MCL-1四核苷酸，癌症诊断和预后，使用癌症诊断和预后来预防和/或治疗癌症的方法，靶向改变的MCL-1核苷酸序列的核酸治疗剂和相关方法，方法 用于鉴定调节天然MCL-1四链体DNA的生物活性的化合物，以及通过本文所述方法鉴定的化合物调节天然MCL-1四链体DNA的生物学活性的方法。 还提供了用四联体相互作用分子选择受试者治疗细胞增殖性病症的方法。