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    MCL-1 quadruplex nucleic acids and uses thereof
    1.
    发明申请
    MCL-1 quadruplex nucleic acids and uses thereof 审中-公开
    MCL-1四核苷酸及其用途

    公开(公告)号：US20060286575A1

    公开(公告)日：2006-12-21

    申请号：US11404552

    申请日：2006-04-14

    申请人： Thomas Farrell ,  Adam Siddiqui-Jain

    发明人： Thomas Farrell ,  Adam Siddiqui-Jain

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer diagnostics and prognostics to prevent and/or treat cancer, nucleic acid therapeutics that target altered MCL-1 nucleotide sequences and related methods, methods for identifying compounds that modulate the biological activity of a native MCL-1 quadruplex DNA, and methods for modulating the biological activity of a native MCL-1 quadruplex DNA with a compound identified by the methods described herein. Also provided are methods of selecting a subject for treatment of a cell-proliferative disorder with a quadruplex-interacting molecule.

    摘要翻译： 已经发现了MCL-1调节区的生物学显着的四重结构。 四连体形成核苷酸序列中的某些突变改变了四重结构，并与癌症和其他疾病有关。 因此，本文提供了MCL-1四核苷酸，癌症诊断和预后，使用癌症诊断和预后来预防和/或治疗癌症的方法，靶向改变的MCL-1核苷酸序列的核酸治疗剂和相关方法，方法 用于鉴定调节天然MCL-1四链体DNA的生物活性的化合物，以及通过本文所述方法鉴定的化合物调节天然MCL-1四链体DNA的生物学活性的方法。 还提供了用四联体相互作用分子选择受试者治疗细胞增殖性病症的方法。

    INFRASTRUCTURE FOR UTILIZING ELECTRONIC RECORDS
    2.
    发明申请
    INFRASTRUCTURE FOR UTILIZING ELECTRONIC RECORDS 有权

    公开(公告)号：US20210375415A1

    公开(公告)日：2021-12-02

    申请号：US17122728

    申请日：2020-12-15

    申请人： Thomas Farrell

    发明人： Thomas Farrell

    IPC分类号： G16H20/10 ,  G16H10/60

    摘要： The disclosure according to some exemplary embodiments relates generally to an infrastructure for electronic records (e.g., electronic medical records (EMRs), electronic health records (EHRs), and personal health records (PHRs)). The infrastructure allows the use, for example, of the electronic records and other information sources to determine drug and other treatment prices that may differ from listed prices based on various factors, such as approved indication treated, the organization and/or individual responsible for payment, whether and what other drug or drugs are used as part of the treatment regimen, a diagnosis and treatment plan, and responses to treatment, among other factors. Advantageously, in some embodiments, systems and methods using the infrastructure allows patients to receive lower drug and treatment prices tailored to the patients' needs and can increase patients' access to drugs and other treatments.

    INFRASTRUCTURE FOR UTILIZING ELECTRONIC RECORDS
    3.
    发明申请
    INFRASTRUCTURE FOR UTILIZING ELECTRONIC RECORDS 审中-公开

    公开(公告)号：US20190244697A1

    公开(公告)日：2019-08-08

    申请号：US16267109

    申请日：2019-02-04

    申请人： Thomas Farrell

    发明人： Thomas Farrell

    IPC分类号： G16H20/10 ,  G16H10/60

    CPC分类号： G16H20/10 ,  G16H10/60

    摘要： The disclosure according to some exemplary embodiments relates generally to an infrastructure for electronic records (e.g., electronic medical records (EMRs), electronic health records (EHRs), and personal health records (PHRs)). The infrastructure allows the use, for example, of the electronic records and other information sources to determine drug and other treatment prices that may differ from listed prices based on various factors, such as approved indication treated, the organization and/or individual responsible for payment, whether and what other drug or drugs are used as part of the treatment regimen, a diagnosis and treatment plan, and responses to treatment, among other factors. Advantageously, in some embodiments, systems and methods using the infrastructure allows patients to receive lower drug and treatment prices tailored to the patients' needs and can increase patients' access to drugs and other treatments.

    Method for optimising the calibration process of a tuneable laser
    4.
    发明授权
    Method for optimising the calibration process of a tuneable laser 有权
    优化可调激光器校准过程的方法

    公开(公告)号：US07436864B2

    公开(公告)日：2008-10-14

    申请号：US10507328

    申请日：2003-03-11

    申请人： Thomas Farrell ,  Neil Ryan ,  John Levins ,  Tommy Mullane

    发明人： Thomas Farrell ,  Neil Ryan ,  John Levins ,  Tommy Mullane

    IPC分类号： H01S3/10 ,  H01S3/13

    CPC分类号： H01S5/062 ,  H01S5/0617 ,  H01S5/06255 ,  H01S5/0687

    摘要： A method relating to the calibration of tuneable lasers is described. The method provides for the provision of correct control currents so as to achieve each of desired output frequencies from the laser. The correct currents are determined by forming a matrix of the output characteristics of the laser at specific tuning currents and processing that matrix to determine stable operating points within the matrix.

    摘要翻译： 描述了与可调谐激光器的校准相关的方法。 该方法提供了提供正确的控制电流，以便实现来自激光器的每个期望的输出频率。 通过在特定调谐电流下形成激光器的输出特性的矩阵来确定正确的电流，并处理该矩阵以确定矩阵内的稳定工作点。

    MULTIPLE VENTURI TUBE GAS FUEL INJECTOR FOR A COMBUSTOR
    7.
    发明申请
    MULTIPLE VENTURI TUBE GAS FUEL INJECTOR FOR A COMBUSTOR 失效
    多个VENTURI管气体燃料喷射器

    公开(公告)号：US20060156730A1

    公开(公告)日：2006-07-20

    申请号：US10905686

    申请日：2005-01-17

    申请人： Constantin Dinu ,  Thomas Farrell ,  Kevin Gordon ,  James Storey ,  Krishna Venkataraman

    发明人： Constantin Dinu ,  Thomas Farrell ,  Kevin Gordon ,  James Storey ,  Krishna Venkataraman

    IPC分类号： F23R3/40

    CPC分类号： F23R3/40 ,  F23D23/00 ,  F23R3/286 ,  Y02E20/348

    摘要： A gas fuel injector includes a first header plate; a second header plate spaced downstream from the upstream header plate; and a plurality of venturi tubes arranged in rows and sealably secured to the first and second header plates. Each of the venturi tubes includes an inlet section, a throat section and an exit. The exit is shaped into a pattern that reduces space between each of the venturi tubes at the exit of each of the plurality of venturi tubes.

    摘要翻译： 气体燃料喷射器包括第一集管板; 与上游集管板隔开的第二集管板; 以及排列成行并可密封地固定到第一和第二集管板的多个文丘里管。 每个文氏管包括入口部分，喉部和出口。 出口被成形为一种图案，其减小了在多个文氏管中的每一个的出口处的每个文丘里管之间的空间。

    Method for compensation of degradation in tunable lasers
    8.
    发明授权
    Method for compensation of degradation in tunable lasers 有权
    可调谐激光器劣化补偿方法

    公开(公告)号：US07478007B2

    公开(公告)日：2009-01-13

    申请号：US10533349

    申请日：2003-10-30

    申请人： Thomas Farrell ,  David McDonald ,  Thomas Mullane

    发明人： Thomas Farrell ,  David McDonald ,  Thomas Mullane

    IPC分类号： G01K11/30

    CPC分类号： H01S5/0014 ,  H01S5/0021 ,  H01S5/0617 ,  H01S5/06256 ,  H01S5/0683 ,  H01S5/1209

    摘要： The invention provides a method to compensate for degradation in a tunable laser and ensure its performance by tracking the degradation and adjusting the control information accordingly. This is accomplished by performing some measurements of the output of the tunable laser at an initial setup or calibration procedure. Then, by effecting a periodic repetition of these measurements and using a comparison between these two measurements the present invention provides for a compensation factor for the operating conditions, primarily in the form of a look up table of operating points of the laser. These measurements show how much the operating points of the laser have drifted over the period since the last set of measurements, which provide control informatIon to compensate for degradation in the laser.

    摘要翻译： 本发明提供了一种补偿可调激光器的劣化并通过跟踪劣化并相应地调整控制信息来确保其性能的方法。 这是通过在初始设置或校准过程中对可调谐激光器的输出进行一些测量来实现的。 然后，通过进行这些测量的周期性重复并且使用这两个测量之间的比较，本发明主要以激光的操作点的查找表的形式提供了操作条件的补偿因子。 这些测量显示激光器的工作点在自最后一组测量以来的这段时间内漂移了多少，这些测量提供了控制信息来补偿激光器的退化。

    Enclosed Protective Packaging
    10.
    发明申请
    Enclosed Protective Packaging 审中-公开
    封闭式保护性包装

    公开(公告)号：US20080183181A1

    公开(公告)日：2008-07-31

    申请号：US11668657

    申请日：2007-01-30

    申请人： Kevin Treacy ,  Thomas Farrell ,  Patricia O'beirne ,  Kevin Boyle ,  John Clifford

    发明人： Kevin Treacy ,  Thomas Farrell ,  Patricia O'beirne ,  Kevin Boyle ,  John Clifford

    IPC分类号： A61F2/00

    CPC分类号： A61L2/26 ,  A61L2/206 ,  A61L2202/182 ,  A61L2202/24 ,  A61M25/002

    摘要： A vascular treatment device delivery system includes an elongated protective sheath having a distal end and a proximal end, a delivery catheter disposed within an axial lumen of the elongated protective sheath, and a luer fitting operably connected to a proximal end of the delivery catheter. The system further includes a sealable container attached to the proximal end of the protective sheath, the sealable container surrounding the luer fitting and a sterility barrier attached to a portion of the sealable container.

    摘要翻译： 血管治疗装置递送系统包括具有远端和近端的细长保护护套，设置在细长保护护套的轴向内腔内的输送导管以及可操作地连接到输送导管的近端的鲁尔接头。 该系统还包括附接到保护护套的近端的可密封容器，围绕鲁尔接头的可密封容器和附着到可密封容器的一部分的无菌屏障。