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    Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation
    1.
    发明授权
    Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation 有权
    用血管内刺激预防心律失常的方法和装置

    公开(公告)号：US08792979B2

    公开(公告)日：2014-07-29

    申请号：US11549704

    申请日：2006-10-16

    申请人： Adam W. Cates

    发明人： Adam W. Cates

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/3962

    摘要： Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.

    摘要翻译： 某些心律失常可以通过适当的电刺激自主神经来保护心脏来预防。 植入式心律管理装置被配置为当预测通过血管内电极存在自主神经不平衡时递送这种刺激。 可以基于昼夜节律，检测到的心率或检测到的心率变异性来预测自主不平衡存在。

    Patient stratification for implantable subcutaneous cardiac monitoring and therapy
    2.
    发明授权
    Patient stratification for implantable subcutaneous cardiac monitoring and therapy 失效
    可植入式皮下心脏监测和治疗的患者分层

    公开(公告)号：US07047071B2

    公开(公告)日：2006-05-16

    申请号：US10799341

    申请日：2004-03-12

    申请人： Darrell Orvin Wagner ,  Adam W. Cates ,  Curtis Charles Lindstrom

    发明人： Darrell Orvin Wagner ,  Adam W. Cates ,  Curtis Charles Lindstrom

    IPC分类号： A61N1/18 ,  A61N1/38

    CPC分类号： A61N1/3962 ,  A61N1/05 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/3956

    摘要： Systems and methods of verifying that implantable cardiac devices operate as intended in a particular patient involve one or more of determining proper placement of system components, determining stimulus levels useful for individual patient stratification, and determining stimulus levels that indicate efficacy of devices, implantable within a given patient. A pacing stimulus set at a surface pacing level is delivered to a patient's heart using surface electrodes. The patient is determined to not be a candidate for implantation of a subcutaneous defibrillation system if the surface pacing level needed to capture the heart exceeds a predetermined level. The patient may be determined to be a candidate for implantation of a subcutaneous system if the surface pacing level needed to effect capture is within an acceptance level. Such determinations are preferably based on a proportionality relationship between a subcutaneous defibrillation level and a surface pacing level.

    摘要翻译： 验证可植入心脏装置如预期在特定患者中操作的系统和方法涉及确定系统组件的适当放置的一个或多个，确定对于个体患者分层有用的刺激水平，以及确定指示可植入在内部的装置的功效的刺激水平 给予病人 使用表面电极将设置在表面起搏水平的起搏刺激传递给患者的心脏。 如果需要捕获心脏的表面起搏水平超过预定水平，则患者被确定为不是用于植入皮下除颤系统的候选者。 如果需要进行捕获的表面起搏水平处于接受程度之内，则患者可能被确定为植入皮下系统的候选者。 这种测定优选基于皮下除颤水平和表面起搏水平之间的比例关系。

    STIMULUS WAVEFORMS FOR BAROREFLEX ACTIVATION
    6.
    发明申请
    STIMULUS WAVEFORMS FOR BAROREFLEX ACTIVATION 审中-公开
    刺激激活的刺激波形

    公开(公告)号：US20080167696A1

    公开(公告)日：2008-07-10

    申请号：US11963357

    申请日：2007-12-21

    申请人： Adam W. Cates ,  Martin A. Rossing

    发明人： Adam W. Cates ,  Martin A. Rossing

    IPC分类号： A61N1/18

    CPC分类号： A61N1/0556 ,  A61N1/36114 ,  A61N1/36117

    摘要： A method and apparatus for stimulation of a baroreflex system of a patient is provided. A method comprises establishing a therapy regimen including at least one pulse which includes at least two phases. Each phase has a polarity which is different than that of the other phase. The baroreflex system of the patient is activated with at least one baroreflex activation device which is responsive to the therapy regimen.

    摘要翻译： 提供了用于刺激患者的压力反射系统的方法和装置。 一种方法包括建立包括至少一个包括至少两个相的脉冲的治疗方案。 每相具有与另一相不同的极性。 患者的压力反射系统通过响应于治疗方案的至少一个压力反射激活装置来激活。

    Subcutaneous cardiac stimulator employing post-shock transthoracic asystole prevention pacing
    7.
    发明授权
    Subcutaneous cardiac stimulator employing post-shock transthoracic asystole prevention pacing 有权
    皮下心脏刺激器采用后休克经胸痛预防起搏

    公开(公告)号：US07392081B2

    公开(公告)日：2008-06-24

    申请号：US10377274

    申请日：2003-02-28

    申请人： Darrell Orvin Wagner ,  Adam W. Cates ,  Kristine M. Larsen-Kelly

    发明人： Darrell Orvin Wagner ,  Adam W. Cates ,  Kristine M. Larsen-Kelly

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3962 ,  A61N1/3756 ,  A61N1/3918

    摘要： Transthoracic cardiac stimulation therapies provide for detection and treatment of cardiac asystole subsequent to delivery of a defibrillation therapy. A pacing therapy is transthoracicly delivered to terminate detected cardiac asystole using residual energy from a defibrillation energy storage source. The residual energy usable for the pacing therapy is sufficient to transthoracicly deliver at least one pacing pulse, and is typically sufficient to deliver a series of pacing pulses, prior to depletion of the defibrillation energy storage source. Detection of cardiac asystole is performed following delivery of each pacing pulse, and subcutaneous pacing support is terminated in response to detecting cardiac asystole termination.

    摘要翻译： 经胸静脉心脏刺激治疗提供了在除颤治疗后的心脏停搏时的检测和治疗。 通过经胸廓输送起搏治疗，以使用来自除颤能量存储源的剩余能量终止检测到的心脏停搏。 可用于起搏治疗的剩余能量足以经胸输送至少一个起搏脉冲，并且通常足以在除颤能量存储源耗尽之前递送一系列起搏脉冲。 在每次起搏脉搏输送后进行心脏停搏的检测，响应检测心脏停搏停止而终止皮下起搏支持。

    Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation
    9.
    发明授权
    Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation 有权

    公开(公告)号：US07123959B2

    公开(公告)日：2006-10-17

    申请号：US10105941

    申请日：2002-03-25

    申请人： Adam W. Cates

    发明人： Adam W. Cates

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36114 ,  A61N1/3962

    摘要： Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.

    System and method for determining patient-specific implantable medical device programming parameters
    10.
    发明授权
    System and method for determining patient-specific implantable medical device programming parameters 有权
    用于确定患者特异性可植入医疗装置编程参数的系统和方法

    公开(公告)号：US08285378B1

    公开(公告)日：2012-10-09

    申请号：US10950876

    申请日：2004-09-27

    申请人： Bruce KenKnight ,  Eric Lovett ,  Adam W. Cates ,  Amir Tehrani

    发明人： Bruce KenKnight ,  Eric Lovett ,  Adam W. Cates ,  Amir Tehrani

    IPC分类号： A61N1/02

    CPC分类号： A61N1/37235 ,  A61N1/37282 ,  G06F19/00 ,  G16H40/40

    摘要： A system and method for determining patient-specific implantable medical device programming parameters are presented. A set of physiological measures collected through a plurality of sensors monitoring physiological functions in a patient are assimilated. The physiological measures set are analyzed to identify physiological idiosyncrasies specific to the patient and to optimize the therapy to be delivered through an implantable medical device. A patient profile is formed including a plurality of programming parameters and the patient profile is preprogrammed into the implantable medical device prior to implantation in the patient.

    摘要翻译： 提出了一种用于确定患者特异性可植入医疗器械编程参数的系统和方法。 通过监测患者生理功能的多个传感器收集的一组生理测量被同化。 分析生理测量集以确定特定于患者的生理特征并优化通过可植入医疗装置递送的治疗。 形成包括多个编程参数的患者轮廓，并且在植入患者之前将患者轮廓预编程到可植入医疗装置中。