公开(公告)号：US08158633B2

公开(公告)日：2012-04-17

申请号：US10525115

申请日：2003-08-12

Applicant: Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

Inventor： Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC classification number: C07D487/04

Abstract: The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US20120010224A1

公开(公告)日：2012-01-12

申请号：US13233833

申请日：2011-09-15

Applicant: Martin HENDRIX ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin HENDRIX ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/519 ,  A61P25/28 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US20100035882A1

公开(公告)日：2010-02-11

申请号：US12444708

申请日：2007-10-02

Applicant: Peter Ellinghaus ,  Andreas Wilmen ,  Martin Hendrix ,  Adrian Tersteegen

Inventor： Peter Ellinghaus ,  Andreas Wilmen ,  Martin Hendrix ,  Adrian Tersteegen

IPC: A61K31/53 ,  A61P9/00

CPC classification number: A61K31/53 ,  C12Q1/44 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2800/32

Abstract: The invention relates to the use of PDE2A inhibitors for the manufacture of a medicament for the treatment and/or prophylaxis of coronary diseases, especially stable and unstable angina pectoris, acute myocardial infarction, prophylaxis of myocardial infarction, heart failure, and high blood pressure and the sequelae of atherosclerosis, and vascular disorders, disorders of the kidney, especially renal failure, inflammatory disorders, erectile dysfunction and prevention of sudden heart death.

Abstract translation: 本发明涉及PDE2A抑制剂在制备用于治疗和/或预防冠状动脉疾病，特别是稳定和不稳定性心绞痛，急性心肌梗死，预防心肌梗塞，心力衰竭和高血压的药物中的用途，以及 动脉粥样硬化的后遗症和血管疾病，肾脏疾病，特别是肾功能衰竭，炎症性疾病，勃起功能障碍和预防心脏死亡突发。

公开(公告)号：US20090258877A1

公开(公告)日：2009-10-15

申请号：US12334131

申请日：2008-12-12

Applicant: Stephan Siegel ,  Andreas Wilmen ,  Niels Svenstrup ,  Mark Jean Gnoth ,  Stefan Heitmeier ,  Ulrich Rester ,  Adrian Tersteegen ,  Michael Gerisch

Inventor： Stephan Siegel ,  Andreas Wilmen ,  Niels Svenstrup ,  Mark Jean Gnoth ,  Stefan Heitmeier ,  Ulrich Rester ,  Adrian Tersteegen ,  Michael Gerisch

IPC: A61K31/53 ,  C07D471/04 ,  C07D487/04 ,  A61K31/498 ,  A61P7/00

CPC classification number: C07D487/04

Abstract: The invention relates to substituted triazolotriazines and triazolopyrazines and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular haematologic disorders, preferably of leukopenias and neutropenias.

Abstract translation: 本发明涉及取代的三氮代三嗪和三唑并吡嗪及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少症和中性粒细胞减少症的药物的用途。

公开(公告)号：US08809348B2

公开(公告)日：2014-08-19

申请号：US12580725

申请日：2009-10-16

Applicant: Martin Hendrix ,  Lars Barfacker ,  Christine Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Barfacker ,  Christine Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/519 ,  A61P25/28 ,  A61P25/18 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US08741907B2

公开(公告)日：2014-06-03

申请号：US13193931

申请日：2011-07-29

Applicant: Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

Inventor： Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

IPC: A61K31/519 ,  A61P25/28 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The invention relates to alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving learning and/or memory. The alkyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.

Abstract translation: 本发明涉及烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善学习和/或记忆的药物的用途。 烷基取代的吡唑并嘧啶具有式（I）：具有如权利要求中所定义的变量。

公开(公告)号：US20140050743A1

公开(公告)日：2014-02-20

申请号：US13980431

申请日：2012-01-17

Applicant: Frank Dittmer ,  Anja Buchmüller ,  Christoph Gerdes ,  Adrian Tersteegen ,  Mark Jean Gnoth ,  Lars Linden ,  Axel Harrenga ,  Joanna Grudzinska-Goebel ,  Mario Jeske ,  Martina Schäfer ,  Jörg Birkenfeld ,  Holger Paulsen ,  Ricarda Finnern ,  Anke Mayer-Bartschmid ,  Andrea Eicker ,  Simone Greven ,  Susanne Steinig

Inventor： Frank Dittmer ,  Anja Buchmüller ,  Christoph Gerdes ,  Adrian Tersteegen ,  Mark Jean Gnoth ,  Lars Linden ,  Axel Harrenga ,  Joanna Grudzinska-Goebel ,  Mario Jeske ,  Martina Schäfer ,  Jörg Birkenfeld ,  Holger Paulsen ,  Ricarda Finnern ,  Anke Mayer-Bartschmid ,  Andrea Eicker ,  Simone Greven ,  Susanne Steinig

IPC: C07K16/44

CPC classification number: C07K16/44 ,  A61K2039/505 ,  A61K2300/00 ,  C07K2317/55 ,  C07K2317/76

Abstract: The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract translation: 本发明涉及抗原结合区，抗体，抗原结合抗体片段和抗体模拟物的鉴定和用途，其中和抗凝血剂在体外和/或体内的抗凝血作用。 本发明的抗体和功能片段和抗体模拟物可用于特异性地逆转抗凝血剂的药理学作用。 用于治疗（解毒剂）和/或诊断目的的FXa抑制剂。 本发明还提供了编码前述分子的核酸序列，含有该分子的载体，药物组合物和具有使用说明书的试剂盒。

公开(公告)号：US20130338137A1

公开(公告)日：2013-12-19

申请号：US13599975

申请日：2012-08-30

Applicant: Markus FOLLMANN ,  Johannes-Peter STASCH ,  Gorden REDLICH ,  Nils GRIEBENOW ,  Dieter LANG ,  Frank WUNDER ,  Walter HÜBSCH ,  Niels LINDNER ,  Alexandros VAKALOPOULOS ,  Adrian TERSTEEGEN

Inventor： Markus FOLLMANN ,  Johannes-Peter STASCH ,  Gorden REDLICH ,  Nils GRIEBENOW ,  Dieter LANG ,  Frank WUNDER ,  Walter HÜBSCH ,  Niels LINDNER ,  Alexandros VAKALOPOULOS ,  Adrian TERSTEEGEN

IPC: C07D487/04 ,  A61K45/06 ,  C07D491/20 ,  C07D498/08 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/519 ,  A61K31/5377

CPC classification number: A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20 ,  C07D498/08 ,  C07D519/00

Abstract: The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.

公开(公告)号：US08436003B2

公开(公告)日：2013-05-07

申请号：US12992715

申请日：2009-05-02

Applicant: Stephan Siegel ,  Andreas Wilmen ,  Niels Svenstrup ,  Mark Jean Gnoth ,  Adrian Tersteegen ,  Ulrich Rester

Inventor： Stephan Siegel ,  Andreas Wilmen ,  Niels Svenstrup ,  Mark Jean Gnoth ,  Adrian Tersteegen ,  Ulrich Rester

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC classification number: C07D487/04

Abstract: The invention relates to substituted triazolopyrimidines of the formula processes for their preparation, and their use for the treatment of hematological disorders.

Abstract translation: 本发明涉及其制备方法的取代三唑并嘧啶及其制备方法及其用于治疗血液病症的用途。

公开(公告)号：US20100184740A1

公开(公告)日：2010-07-22

申请号：US12665729

申请日：2008-06-07

Applicant: Swen Allerheiligen ,  Marcus Bauser ,  Dirk Heimbach ,  Stefan Heitmeier ,  Mark Jean Gnoth ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Susanne Röhrig ,  Ulrich Rester ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Adrian Tersteegen

Inventor： Swen Allerheiligen ,  Marcus Bauser ,  Dirk Heimbach ,  Stefan Heitmeier ,  Mark Jean Gnoth ,  Christoph Gerdes ,  Georges Von Degenfeld ,  Susanne Röhrig ,  Ulrich Rester ,  Elke Dittrich-Wengenroth ,  Uwe Saatman ,  Adrian Tersteegen

IPC: A61K31/4439 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/496 ,  C07D417/14 ,  A61K31/541 ,  A61K31/553 ,  A61P7/02 ,  A61P7/00 ,  A61P9/12 ,  A61P29/00

CPC classification number: C07D413/14

Abstract: The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.

Abstract translation: 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。