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公开(公告)号:US08273752B2
公开(公告)日:2012-09-25
申请号:US12529711
申请日:2008-03-04
申请人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04 , A61K31/519
摘要: The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号:US07402683B2
公开(公告)日:2008-07-22
申请号:US10512724
申请日:2003-04-14
申请人: Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人: Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号: C07D207/00 , C07D215/38 , C07D213/00 , C07D403/02 , C07D231/00 , A01N43/36 , A01N43/56 , A01N43/40 , A01N43/42
CPC分类号: C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要: The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译: 本发明涉及化合物,其制备方法,包含它们的药物组合物,以及它们在人或动物,特别是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号:US20080051424A1
公开(公告)日:2008-02-28
申请号:US11788649
申请日:2007-04-20
申请人: Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人: Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
IPC分类号: A61K31/506 , A61P31/04 , C07D239/24
CPC分类号: C07K7/06
摘要: The invention relates to nonadepsipeptides and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译: 本发明涉及非吸收肽及其制备方法以及其用于生产用于治疗和/或预防疾病,特别是细菌感染性疾病的药物的用途。
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公开(公告)号:US20090258877A1
公开(公告)日:2009-10-15
申请号:US12334131
申请日:2008-12-12
申请人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/53 , C07D471/04 , C07D487/04 , A61K31/498 , A61P7/00
CPC分类号: C07D487/04
摘要: The invention relates to substituted triazolotriazines and triazolopyrazines and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular haematologic disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的三氮代三嗪和三唑并吡嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号:US20060122201A1
公开(公告)日:2006-06-08
申请号:US10506006
申请日:2003-02-14
申请人: Niels Svenstrup , Alexander Kuhl , Dietmar Flubacher , Michael Brands , Kerstin Ehlert , Christoph Ladel , Michael Ottneder , Jorg Keldenich , Marcus Bauser
发明人: Niels Svenstrup , Alexander Kuhl , Dietmar Flubacher , Michael Brands , Kerstin Ehlert , Christoph Ladel , Michael Ottneder , Jorg Keldenich , Marcus Bauser
IPC分类号: A61K31/513 , C07D403/02 , C07D239/46
CPC分类号: C07D239/545 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: The invention relates to uracil-thioethers, pharmaceutical compositions containing said compounds and to a method for the production thereof. The invention also relates to the use of said substances in the treatment of diseases in humans and animals.
摘要翻译: 本发明涉及尿嘧啶硫醚,含有所述化合物的药物组合物及其生产方法。 本发明还涉及所述物质用于治疗人和动物疾病的用途。
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公开(公告)号:US08664246B2
公开(公告)日:2014-03-04
申请号:US13056676
申请日:2009-07-21
申请人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
发明人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
IPC分类号: A61K31/4545 , C07D401/12
CPC分类号: C07D401/14 , C07D401/12
摘要: The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia.
摘要翻译: 本发明涉及取代的吡啶及其制备方法及其制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少和中性白细胞减少症的药物的用途。
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公开(公告)号:US20130040946A1
公开(公告)日:2013-02-14
申请号:US13625086
申请日:2012-09-24
申请人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号: A61K31/519 , C12N5/0775 , A61P7/00 , C12N5/0789 , C07D487/04 , A61K31/5377
CPC分类号: C07D487/04 , A61K31/519
摘要: The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号:US20110190316A1
公开(公告)日:2011-08-04
申请号:US13056676
申请日:2009-07-21
申请人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
发明人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Adrian Tersteegen , Ulrich Rester
IPC分类号: A61K31/496 , C07D401/14 , A61K31/4545 , C12N5/0789 , A61P7/00
CPC分类号: C07D401/14 , C07D401/12
摘要: The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia.
摘要翻译: 本发明涉及取代的吡啶及其制备方法及其制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少和中性白细胞减少症的药物的用途。
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公开(公告)号:US20090149528A1
公开(公告)日:2009-06-11
申请号:US12217248
申请日:2008-07-02
申请人: Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
发明人: Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Joseph Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann , Peter Nell
IPC分类号: A61K31/4025 , C07D207/333 , A61P31/04
CPC分类号: C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要: The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.
摘要翻译: 本发明涉及化合物,其制备方法,包含它们的药物组合物,以及它们在人或动物尤其是细菌感染疾病的治疗和/或预防中的用途。
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公开(公告)号:US20080058253A1
公开(公告)日:2008-03-06
申请号:US11788690
申请日:2007-04-19
申请人: Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人: Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
摘要: The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译: 本发明涉及非吸收肽及其制备方法及其用于生产用于治疗和/或预防疾病,特别是细菌感染性疾病的药物。
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